DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oseg1 and ift122

DIOPT Version :9

Sequence 1:	NP_001286982.1	Gene:	Oseg1 / 38957	FlyBaseID:	FBgn0265102	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_998055.1	Gene:	ift122 / 405826	ZFINID:	ZDB-GENE-040426-2449	Length:	1187	Species:	Danio rerio

Alignment Length:	1195	Identity:	543/1195 - (45%)
Similarity:	798/1195 - (66%)	Gaps:	53/1195 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRGVLKWLERIEFPNSKDN-EISVHNVCYAPDGSQLVVAAGDRLLIYDPNDGSLLNTLKAHKDTV 64
            ||.|..|::::   :.:|. |..::::.:.||||||:||||:|:|:||..||:|:..||.|||||
Zfish     1 MRAVPTWIDKV---HDRDKVEQCIYDLAFRPDGSQLIVAAGNRVLVYDTADGTLIQPLKGHKDTV 62

  Fly    65 NCVAYSRDGKRFASGASDKMVIVWSPQLEGLLKYSHGDSIQCMSFNPVSHHLASCSLSDFAFWSA 129
            .||||::||||||||::||.:|:|:.:|||:|||:|.|||||:|:|||:|.|||||..||..||.
Zfish    63 YCVAYAKDGKRFASGSADKSIIIWTSKLEGILKYTHNDSIQCVSYNPVTHQLASCSSGDFGLWSP 127

  Fly   130 DQKAVQKYKISARVNGCSWTNDGQYLILGLANGTISIRNKLGEEKGRIDRPGGPNSNVFSVQCCP 194
            :||:|.|:|:|:::..|.||||||||.||:.||.:|||||.||||.:|:||||.:|.|:|:...|
Zfish   128 EQKSVSKHKVSSKITCCGWTNDGQYLALGMMNGVVSIRNKNGEEKVKIERPGGSSSPVWSIAWNP 192

  Fly   195 ASGPGSVDTIGVVDWSQTLSFHTLSGQMIGKERTLGFDPLCLQYFPNGEFCLVGGCTGGLHFFTR 259
            :....: |.:.|.||.|.|||:.|||:.|||:|:|.|||.|:.:|..||:.::.|.......:||
Zfish   193 SKDEHN-DILAVADWGQKLSFYQLSGKQIGKDRSLTFDPCCVSFFSKGEYMVLCGSDRQAALYTR 256

  Fly   260 EGIRLGTLGDTFDTWIWTVALHPNGQSYTIGCQDGTLACFNIASSTVHALYRERYAFRENMCDVI 324
            :|:|||::.:. :.|:||..:.|:.....:||||||:|.|.:..||||.||::|||:|::|.|||
Zfish   257 DGVRLGSIAEQ-NAWVWTCRVKPDSNYVVVGCQDGTIAFFQLIFSTVHGLYKDRYAYRDSMTDVI 320

  Fly   325 IQHLISGQKVRIKCRDLVQKIAIYRNRLAVQLPERVVLYELSSGEDQPMHYKVREKIQQKFDCSL 389
            :||||:.||||||||:||:||||||:|||:||||::::|||.|.:...|||:|:|||.::|:|:|
Zfish   321 VQHLITEQKVRIKCRELVKKIAIYRSRLAIQLPEKILIYELLSDDSADMHYRVKEKICRRFECNL 385

  Fly   390 LVVCGRHIVLCQEKRLQCLDFMGVLQREWIMDSFIRYIKVTGGPVGREGLMVGLKNGQVFRIFLN 454
            ||||.:||:||||||||||.|..:.||||:|:|.||||||.|||.|||||:||||||.:.:||::
Zfish   386 LVVCSQHIILCQEKRLQCLSFTALRQREWLMESLIRYIKVIGGPAGREGLLVGLKNGAILKIFVD 450

  Fly   455 NSLPLLITTAVSAVRCLDINSKRSKIAVVDDVGRLVVRDVINDTILYQDTGVNSVTWNTHLDSML 519
            |..|:.:....::|||||::|.||::||||:....:|.|:....:|:|:...|||.|||..:.||
Zfish   451 NPFPITLLKQNTSVRCLDMSSNRSRLAVVDEHNTCLVYDIHTRELLFQEPNANSVAWNTQCEDML 515

  Fly   520 CYTHTTGG--LSVRVGNLPPRAPQNMHGVVVGLCGATAFCLRGNIMHNTPLALGSTMWQFIEAGL 582
            |:   :||  |:::..:.|.. .|.:.|.|||..|:..|||....|....:...:.|:|::|..:
Zfish   516 CF---SGGGFLNIKACSFPVH-QQKLQGFVVGYNGSRIFCLHVYSMAAVEVPQSAPMYQYLERRM 576

  Fly   583 FDEAYQVACLGVTTSDWEGLAQSALEALHINIARDAYVKVRNLPWLKLIGELRDQQQRSAVPKEV 647
            |.:||.:||||||.|||..||..|||.|..:.|:.|::::|:|.:|:||..:.::::|.....::
Zfish   577 FQQAYNIACLGVTDSDWRDLATEALEGLDFHTAKKAFIRIRDLRYLELISSIEERKKRGETDNQL 641

  Fly   648 LLAENCAFAGKFKEAARLFLKCGQSSRALEMYTDLRMFDLAQEYIKDGTDQEKKELVRKRAEWAY 712
            .||:..|:.|||.|||:|:.:.||..|||.|||||||||.|::::.....::.|.|::|:|:||.
Zfish   642 FLADVFAYQGKFHEAAKLYRRSGQDGRALSMYTDLRMFDYAKDFLGSADPKDTKLLMKKQADWAK 706

  Fly   713 SVKEPRAAAELLLSAGENQKAIDIVAEQGWADVLYDIGRRLSLTERDSLESVAQNLKTLKALPLA 777
            :.:|||||||:.|||||:.|||.|:.|.||.|:|.|:||||...||.:|...|..|:.|:....|
Zfish   707 NSREPRAAAEMYLSAGEHLKAIQIIGEHGWVDMLIDVGRRLDKAERAALSRCAVFLQQLQQHGYA 771

  Fly   778 AEIFKKLGDEAQVVQLHIEVRDWPEAFRLAESLPELLPTVHYQHGQWLAETDQFIEAHQAYIKAG 842
            ||::.|:||...::|||:....|.|||.|.|..|:....|:..:.|||||.|:|.||.:|:.|||
Zfish   772 AELYSKMGDLRALLQLHVHATHWDEAFSLVEKHPQFRDDVYVPYAQWLAEHDRFEEAQRAFHKAG 836

  Fly   843 RTKEANRLLKQLSNTAIVEERYLDASYFYWLLAKQHLDVYHAKEEQNPVDHHLTEYKNHLRVAKV 907
            |..||.|:|:||::.|:||.|:.||||:||:|:.|.||:  |:|:.......|.::.:...:|::
Zfish   837 RQAEAVRVLEQLTHNAVVESRFSDASYYYWMLSMQCLDI--AREDSEQKQEMLKKFHSFQHLAEL 899

  Fly   908 YYAYSVIYSYMKEPFTTHSPVSLFNVSRFILNEVE-HKGVPKGVSMFSVLFTLAKQAKFLQANKL 971
            |:.|..::.||.|||:::.|..|||:|||:.:.:. |  .|.|:|....|:.||||:|.|.|.|:
Zfish   900 YHVYHSVHRYMSEPFSSNMPEILFNISRFLFHNLSTH--TPMGISKVDTLYALAKQSKLLGAYKV 962

  Fly   972 CLLINKRLQSLKPPAGVQEQIDLNFLNSKACKSGFNDPEELLPLCYKCSNYSQHLNS--NCCPTC 1034
            .....::|||||.||..|:.::|:.|..::  ..:.|.|:|:|:||:||..:..||:  |.|..|
Zfish   963 SRHAFEKLQSLKIPARYQDSVELSSLTVRS--KPYRDNEDLIPMCYRCSTNNPLLNNQGNSCINC 1025

  Fly  1035 RQDYIFSFVSFEILPLVQFYPEVDISDAEAERLLLAPAKHAE----------------------- 1076
            ||.:|||..|:|:||||:||.:..|||.||..|:.......|
Zfish  1026 RQPFIFSASSYEVLPLVEFYLDQGISDEEAVSLIDLEVPRVEKNKSWQEMSSGESQCLKLEDGPD 1090

  Fly  1077 --DSDPFNEDVASA------LPLSLDRNGLRAIDPNHVLILKRRGKNVRNVYYRNILPDLQVTYC 1133
              :.|||...::..      :|:.:.|..||::....||| ||....:...|||::|||:.:|.|
Zfish  1091 DPEDDPFTAKLSFEQGGSVFVPVRVSRAVLRSMSRRDVLI-KRWPAPLSWQYYRSLLPDVSITMC 1154

  Fly  1134 PQCLLLFYAEDFELQVLQKGHCPFC 1158
            |.|..:|::||:||.|||...||||
Zfish  1155 PSCFQMFHSEDYELLVLQHSCCPFC 1179

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oseg1	NP_001286982.1	WD40	<8..307	CDD:225201	149/299 (50%)
		WD40	22..296	CDD:295369	142/273 (52%)
		WD40 repeat	25..59	CDD:293791	18/33 (55%)
		WD40 repeat	65..99	CDD:293791	21/33 (64%)
		WD40 repeat	104..136	CDD:293791	20/31 (65%)
		WD40 repeat	144..214	CDD:293791	36/69 (52%)
		WD40 repeat	233..267	CDD:293791	12/33 (36%)
		WD40 repeat	275..301	CDD:293791	11/25 (44%)
		TPR_hemY_coli	<598..789	CDD:273126	85/190 (45%)
ift122	NP_998055.1	WD 1	16..54		18/37 (49%)
		WD40	<21..292	CDD:225201	142/272 (52%)
		WD40 repeat	21..57	CDD:293791	18/35 (51%)
		WD40	55..297	CDD:295369	128/243 (53%)
		WD 2	57..97		26/39 (67%)
		WD40 repeat	63..97	CDD:293791	21/33 (64%)
		WD 3	99..135		22/35 (63%)
		WD40 repeat	102..134	CDD:293791	20/31 (65%)
		WD 4	137..175		23/37 (62%)
		WD40 repeat	142..178	CDD:293791	23/35 (66%)
		WD 5	180..223		18/43 (42%)
		WD40 repeat	185..222	CDD:293791	15/37 (41%)
		WD 6	225..264		15/38 (39%)
		WD40 repeat	230..266	CDD:293791	12/35 (34%)
		WD 7	266..306		16/40 (40%)
		WD40 repeat	271..295	CDD:293791	10/23 (43%)
		WD 8	459..498		15/38 (39%)
		GAT_1	710..>813	CDD:294025	49/102 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1070..1094		0/23 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	980	1.000	Domainoid score	I30
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12819
Inparanoid	1	1.050	1084	1.000	Inparanoid score	I237
OMA	1	1.010	-	-		QHG56394
OrthoDB	1	1.010	-	-		D119591at33208
OrthoFinder	1	1.000	-	-		FOG0007425
OrthoInspector	1	1.000	-	-		oto40752
orthoMCL	1	0.900	-	-		OOG6_104180
Panther	1	1.100	-	-	LDO	PTHR12764
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3289
SonicParanoid	1	1.000	-	-		X5559
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010