DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oseg1 and Ift122

DIOPT Version :9

Sequence 1:	NP_001286982.1	Gene:	Oseg1 / 38957	FlyBaseID:	FBgn0265102	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	XP_038963568.1	Gene:	Ift122 / 312651	RGDID:	1311302	Length:	1242	Species:	Rattus norvegicus

Alignment Length:	1252	Identity:	548/1252 - (43%)
Similarity:	796/1252 - (63%)	Gaps:	113/1252 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRGVLKWLERIEFPNSKDNEISVHNVCYAPDGSQLVVAAGDRLLIYDPNDGSLLNTLKAHKDTVN 65
            ||.||.|.::.        |..::::.:.|||:||::|||:|||:||.:||:||..||.|||||.
  Rat     1 MRAVLTWRDKA--------EQCIYDLAFKPDGTQLILAAGNRLLVYDTSDGTLLQPLKGHKDTVY 57

  Fly    66 CVAYSRDGKRFASGASDKMVIVWSPQLEGLLKYSHGDSIQCMSFNPVSHHLASCSLSDFAFWSAD 130
            ||||::||||||||::||.:|:|:.:|||:|||:|.|||||:|:|||:|.|||||.|||..||.:
  Rat    58 CVAYAKDGKRFASGSADKSIIIWTSKLEGILKYTHNDSIQCVSYNPVTHQLASCSSSDFGLWSPE 122

  Fly   131 QKAVQKYKISARVNGCSWTNDGQYLILGLANGTISIRNKLGEEKGRIDRPGGPNSNVFSVQCCPA 195
            ||:|.|:|.::::..||||||||||.||::||.||||||.||||.:|:||||..|.::|:...|:
  Rat   123 QKSVSKHKSNSKITCCSWTNDGQYLALGMSNGIISIRNKNGEEKVKIERPGGSLSPIWSICWNPS 187

  Fly   196 ------------------------------------SGPGSV----------------------D 202
                                                |..||.                      |
  Rat   188 SRWENIWMSRENEDAEDVIVNRYFQEIPSILKSTVYSSQGSEAEEEEQEEEDDSPRDGNSEEHND 252

  Fly   203 TIGVVDWSQTLSFHTLSGQMIGKERTLGFDPLCLQYFPNGEFCLVGGCTGGLHFFTREGIRLGTL 267
            .:.|.||.|.|||:.|||:.|||:|.|.|||.|:.||..||:.||||....:..||::|:||||:
  Rat   253 ILAVADWGQKLSFYQLSGKQIGKDRPLNFDPCCISYFTKGEYILVGGSDKQVSLFTKDGVRLGTV 317

  Fly   268 GDTFDTWIWTVALHPNGQSYTIGCQDGTLACFNIASSTVHALYRERYAFRENMCDVIIQHLISGQ 332
            |:. ::|:||..:.|:.....:||||||::.:.:..||||.||::|||:|::|.|||:||||:.|
  Rat   318 GEQ-NSWVWTCRVKPDSNYVVVGCQDGTISFYQLIFSTVHGLYKDRYAYRDSMTDVIVQHLITEQ 381

  Fly   333 KVRIKCRDLVQKIAIYRNRLAVQLPERVVLYELSSGEDQPMHYKVREKIQQKFDCSLLVVCGRHI 397
            |||||||:||:|||||:||||:||||::::|||.|.:...|||:|:|||.:||:|:|||||..||
  Rat   382 KVRIKCRELVKKIAIYKNRLAIQLPEKILIYELYSDDSADMHYRVKEKIVKKFECNLLVVCADHI 446

  Fly   398 VLCQEKRLQCLDFMGVLQREWIMDSFIRYIKVTGGPVGREGLMVGLKNGQVFRIFLNNSLPLLIT 462
            :||||||||||.|.||.:|||.|:|.||||||.|||.|||||:|||||||:.:||::|...:::.
  Rat   447 ILCQEKRLQCLSFSGVREREWQMESLIRYIKVIGGPAGREGLLVGLKNGQILKIFVDNLFAIVLL 511

  Fly   463 TAVSAVRCLDINSKRSKIAVVDDVGRLVVRDVINDTILYQDTGVNSVTWNTHLDSMLCYTHTTGG 527
            ...:||||||:::.|:|:||||:....:|.|:....:|:|:...|||.|||..:.|||:   :||
  Rat   512 KQATAVRCLDMSASRNKLAVVDENDTCLVYDIHTKELLFQEPNANSVAWNTQCEDMLCF---SGG 573

  Fly   528 --LSVRVGNLPPRAPQNMHGVVVGLCGATAFCLRGNIMHNTPLALGSTMWQFIEAGLFDEAYQVA 590
              |:::....|.. .|.:.|.|||..|:..|||....|....:...:.|:|:::..:|.||||:|
  Rat   574 GYLNIKASTFPVH-QQKLQGFVVGYNGSKIFCLHVFSMSAVEVPQSAPMYQYLDRKMFKEAYQIA 637

  Fly   591 CLGVTTSDWEGLAQSALEALHINIARDAYVKVRNLPWLKLIGELRDQQQRSAVPKEVLLAENCAF 655
            |||||.:||..||..|||.|....|:.|:.:|::|.:|:||..:.::::|.....::.||:..::
  Rat   638 CLGVTDTDWRELAMEALEGLEFETAKKAFTRVQDLRYLELISTIEERKKRGESNNDLFLADVFSY 702

  Fly   656 AGKFKEAARLFLKCGQSSRALEMYTDLRMFDLAQEYIKDGTDQEKKELVRKRAEWAYSVKEPRAA 720
            .|||.|||:|:.:.|..:.||.|||||.||:.|::::..|..:|.|.|:.|:|:||.::.||:||
  Rat   703 QGKFHEAAKLYKRSGHENLALNMYTDLCMFEYAKDFLGSGDPKETKMLITKQADWARNINEPKAA 767

  Fly   721 AELLLSAGENQKAIDIVAEQGWADVLYDIGRRLSLTERDSLESVAQNLKTLKALPLAAEIFKKLG 785
            .|:.:||||:.|||:|....||.|:|.||.|:|...||:.|...|:..|.|.:...|||.:.|:|
  Rat   768 VEMYISAGEHAKAIEISGSHGWVDMLIDIARKLDKAEREPLLMCARYFKKLDSPGYAAETYLKIG 832

  Fly   786 DEAQVVQLHIEVRDWPEAFRLAESLPELLPTVHYQHGQWLAETDQFIEAHQAYIKAGRTKEANRL 850
            |...:|||:::.:.|.|||.|.|..||....::..:.|||||.|:|.||.:|:.||||..||.|:
  Rat   833 DLKSLVQLYVDTKRWDEAFALGEKHPEFKDDIYVPYAQWLAENDRFEEAQKAFHKAGRQGEAVRV 897

  Fly   851 LKQLSNTAIVEERYLDASYFYWLLAKQHLDVYHAKEEQNPVDHHLTEYKNHLRVAKVYYAYSVIY 915
            |:||::.|:||.|:.||:|:||:|:.|.||:......|.  |..|.::.:...:|::|:.|..|:
  Rat   898 LEQLTHNAVVESRFNDAAYYYWMLSMQCLDMAQVDPAQK--DVMLDKFHHFQHLAELYHGYQTIH 960

  Fly   916 SYMKEPFTTHSPVSLFNVSRFILNEVEHKGVPKGVSMFSVLFTLAKQAKFLQANKLCLLINKRLQ 980
            .|.:|||:...|.:|||:|:|:|:.:. |..|.|:|..:.|||||||:|.|.|.||......:|:
  Rat   961 RYTEEPFSFDLPETLFNISKFLLHSLT-KATPLGISKVNTLFTLAKQSKALGAYKLARHAYDKLR 1024

  Fly   981 SLKPPAGVQEQIDLNFLNSKACKSGFNDPEELLPLCYKCSNYSQHLNS--NCCPTCRQDYIFSFV 1043
            .|:.||.:|:.|:|..|..::  ..|:|.|||:||||:||..:..||:  |.|..|||.:|||..
  Rat  1025 GLQIPARIQKSIELGTLTIRS--KPFHDSEELVPLCYRCSTNNPLLNNLGNVCINCRQPFIFSAS 1087

  Fly  1044 SFEILPLVQFYPEVDISDAEAERL--LLAPAKHAE------------------------DSDPFN 1082
            |:|:|.||:||.|..|:|.||..|  |.||....|                        :.|||.
  Rat  1088 SYEVLHLVEFYLEEGITDEEAVALIDLEAPRHKREGKWQETSSNNSQTLRLDETMDSIGEDDPFT 1152

  Fly  1083 EDV------ASALPLSLDRNGLRAIDPNHVLILKRRGKNVRNVYYRNILPDLQVTYCPQCLLLFY 1141
            ..:      :..:|:.:.|:.||::....||| ||....::..|:|::|||..:|.||.|..:|:
  Rat  1153 AKLSFEQGGSEFVPVVVSRSVLRSMSRRDVLI-KRWPPPLQWQYFRSLLPDASITMCPSCFQMFH 1216

  Fly  1142 AEDFELQVLQKGHCPFC 1158
            :||:||.|||...||:|
  Rat  1217 SEDYELLVLQHACCPYC 1233

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oseg1	NP_001286982.1	WD40	<8..307	CDD:225201	156/356 (44%)
		WD40	22..296	CDD:295369	152/331 (46%)
		WD40 repeat	25..59	CDD:293791	18/33 (55%)
		WD40 repeat	65..99	CDD:293791	21/33 (64%)
		WD40 repeat	104..136	CDD:293791	21/31 (68%)
		WD40 repeat	144..214	CDD:293791	40/127 (31%)
		WD40 repeat	233..267	CDD:293791	16/33 (48%)
		WD40 repeat	275..301	CDD:293791	9/25 (36%)
		TPR_hemY_coli	<598..789	CDD:273126	77/190 (41%)
Ift122	XP_038963568.1	WD40	12..190	CDD:421866	105/177 (59%)
		WD40 repeat	15..51	CDD:293791	18/35 (51%)
		WD40 repeat	57..91	CDD:293791	21/33 (64%)
		WD40 repeat	96..128	CDD:293791	21/31 (68%)
		WD40 repeat	136..172	CDD:293791	25/35 (71%)
		WD40 repeat	223..276	CDD:293791	16/52 (31%)
		WD40 repeat	283..316	CDD:293791	15/32 (47%)
		WD40	285..>351	CDD:421866	27/66 (41%)
		WD40 repeat	324..350	CDD:293791	9/25 (36%)
		PEP_TPR_lipo	<710..953	CDD:274350	102/244 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166342304
Domainoid	1	1.000	737	1.000	Domainoid score	I95
eggNOG	1	0.900	-	-		E2759_KOG1538
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12819
Inparanoid	1	1.050	889	1.000	Inparanoid score	I370
OMA	1	1.010	-	-		QHG56394
OrthoDB	1	1.010	-	-		D119591at33208
OrthoFinder	1	1.000	-	-		FOG0007425
OrthoInspector	1	1.000	-	-		oto96566
orthoMCL	1	0.900	-	-		OOG6_104180
Panther	1	1.100	-	-	LDO	PTHR12764
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5559
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770