DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oseg1 and daf-10

DIOPT Version :9

Sequence 1:	NP_001286982.1	Gene:	Oseg1 / 38957	FlyBaseID:	FBgn0265102	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_501591.2	Gene:	daf-10 / 184883	WormBaseID:	WBGene00000906	Length:	1192	Species:	Caenorhabditis elegans

Alignment Length:	1196	Identity:	412/1196 - (34%)
Similarity:	697/1196 - (58%)	Gaps:	63/1196 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRGVLKWLERIEFPNSKDNEISVHNVCYAPDGSQLVVAAGDRLLIYDPNDGSLLNTLKAHKDTVN 65
            ||..|.|:::|...|::.. :.::::.:.||||:|::||.:::.::|.|:|..:.|||.|||.|.
Worm     1 MRPNLLWVDKILDENNEAG-VCIYDLAFKPDGSELLLAADNKVYLFDVNEGGQMQTLKGHKDLVY 64

  Fly    66 CVAYSRDGKRFASGASDKMVIVWSPQLEGLLKYSHGDSIQCMSFNPVSHHLASCSLSDFAFWSAD 130
            .||:|.:|:.||||.:||:||:|:.:.||.|:|||.|.||||.|||.:..|.:|:|::|..||..
Worm    65 TVAWSHNGELFASGGADKLVILWNEKHEGTLRYSHTDVIQCMMFNPCNQILLTCALNEFGLWSTA 129

  Fly   131 QKAVQKYKISARVNGCSWTNDGQYLILGLANGTISIR---NKLGEEKGRIDRPGGP-------NS 185
            .|.|.|.:...|...|:|..||....:|..:|||::|   |...|....|.|...|       ::
Worm   130 DKNVIKQRSVVRCCSCAWNTDGTIFAIGHGDGTITLRKGTNATEEPSIIIQRDNEPIWGIAFSSN 194

  Fly   186 NVFSVQCCPASGPGSVDTIGVVDWSQTLSFHTLSGQMIGKERTLGFDPLCLQYFPNGEFCLVGGC 250
            ..|:.:....:..|..:.:.|:||::||||::|.|..| :.:.|.|:|.|:.|..|||:.|:||.
Worm   195 RTFASRDSQGNPMGIDEIMAVIDWNKTLSFYSLDGTFI-ESKNLEFEPHCISYCLNGEYLLIGGS 258

  Fly   251 TGGLHFFTREGIRLGTLGDTFDTWIWTVALHPNGQSYTIGCQDGTLACFNIASSTVHALYRERYA 315
            ...|..:||:|:.|||:.. .|.|||:|.:.||.|:..:||.|||:||:|:..||||.:...|||
Worm   259 DKILKIYTRKGVLLGTVAQ-MDHWIWSVTVRPNSQTVAMGCVDGTIACYNLVFSTVHCVDHARYA 322

  Fly   316 FRENMCDVIIQHLISGQKVRIKCRDLVQKIAIYRNRLAVQLPERVVLYELSSG-----EDQPMHY 375
            .|::|.||.:|:|.......|.|.|||:|:::|..:|||||.:::.:|:.:.|     ..:.:.|
Worm   323 NRKSMTDVFVQNLEYRTSSNICCHDLVKKMSLYDTKLAVQLSDKIQIYKQTGGVSKNERRKQLKY 387

  Fly   376 KVREKIQQKFDCSLLVVCGRHIVLCQEKRLQCLDFMGVLQREWIMDSFIRYIKVTGGPVGREGLM 440
            .:::.|::....||:||...|:|:|.:::|:|.||.|:.:|.|.|.|.:||::|.|||..||.|:
Worm   388 TLQDTIRKDLSFSLMVVTHGHLVVCNDEKLECYDFKGIKKRSWNMKSIVRYLRVLGGPAHRETLV 452

  Fly   441 VGLKNGQVFRIFLNNSLPLLITTAVSAVRCLDINSKRSKIAVVDDVGRLVVR--DVINDTILYQD 503
            :|..:|.|:::|::|..|:|:.:..:|::|:|||:.|:.:|.::|.  ||.:  |:.....|.|:
Worm   453 LGTTDGGVYKVFIDNDYPILLDSRKTAIKCIDINANRTVLASIEDT--LVCKWSDIATGETLLQE 515

  Fly   504 TGVNSVTWNTHLDSMLCYTHTTGGLSVRVGNLPPRAPQNMHGVVVGLCGATAFCLRGNIMHN-TP 567
            .|..||.:||..:::..:| |...|.||....|....:.: |.|:|......|||   :.:| .|
Worm   516 PGCYSVVFNTVNENLFAFT-TNNMLHVRTLAAPGHTTRGV-GYVLGFVKNRTFCL---VQYNLIP 575

  Fly   568 LALGST--MWQFIEAGLFDEAYQVACLGVTTSDWEGLAQSALEALHINIARDAYVKVRNLPWLKL 630
            |.:..|  ::|:||.|.|.||.::|||||..:||:.||..||:||..::||.||.:||:...|::
Worm   576 LEVPYTIHLYQYIERGDFKEALRIACLGVVKNDWKYLANKALDALEFDVARKAYKRVRDRKMLRM 640

  Fly   631 IGELRDQQQRSAVPKEVLLAENCAFAGKFKEAARLFLKCGQSSRALEMYTDLRMFDLAQEYIKDG 695
            :.||: :.:.:..|..:|.|...|:..||:|||::|.:.|..:||:|::||:||||..||.:...
Worm   641 VWELK-KMKSNGEPDAILRATILAYTKKFREAAKIFKENGFENRAMELFTDMRMFDDVQEVMTTA 704

  Fly   696 TDQEKKELVRKRAEWAYSVKEPRAAAELLLSAGENQKAIDIVAEQGWADVLYDIGRRLSLTERDS 760
            :.:.||.|:||||.||....:|:.|||:|:|:|:..||..::.:..|.::..:|..::..::.::
Worm   705 SGETKKMLMRKRASWARDANQPKIAAEMLISSGDLDKAALLIIDNDWLELAIEISHKIDRSDLET 769

  Fly   761 LESVAQNLKTLKALPLAAEIFKKLGDEAQVVQLHIEVRDWPEAFRLAESLPELLPTVHYQHGQWL 825
            ::.::..........||:.||:.:.|...:|.:|:....|.:||.:|:..|:.:..|:..:.::|
Worm   770 MKKLSAYFIRKHEFGLASRIFQSINDMKSIVDMHVNAGHWTDAFAIADRHPKYVEDVYLPYARFL 834

  Fly   826 AETDQFIEAHQAYIKAGRTKEANRLLKQLSNTAIVEERYLDASYFYWLLAKQHLDVYHAKEEQNP 890
            ||.|:|.||.:|:.:||:.:||..:|:||::.::.|.|:.||.::||||::|:||  .::.|:|.
Worm   835 AERDRFEEAQKAFHRAGKEQEAMHVLEQLTSNSVNENRFADAGFYYWLLSQQYLD--RSQTEENL 897

  Fly   891 VDHHLTEYKNHLRVAKVYYAYSVIYSYMKEPFTTHSPVSLFNVSRFILNEVEHKGVP--KGVSMF 953
            .  .|.:.|....:|..||||..::.:..:||:.....::.|::|::      ...|  ..:|..
Worm   898 T--LLNKAKEAASLADAYYAYYPVFIFCSQPFSFERNENILNMARYL------TFTPYIDNISKV 954

  Fly   954 SVLFTLAKQAKFLQANKLCLLINKRLQSLK--PPAGVQEQIDLNFLNSKACKSGFNDPEELLPLC 1016
            .|.||:||.|..:.|.|.......:|.:|:  |...:..||::..||.:|  ..|.|.|.:.|:|
Worm   955 FVYFTIAKIANEMGAYKSARTALDQLTNLRVLPQFELDGQIEVMTLNIRA--KPFTDVESMQPMC 1017

  Fly  1017 YKCSNYSQHLNSNCCPTCRQDYIFSFVSFEILPLVQFYPEVDISDAEAERLLLAPAKHAEDSDPF 1081
            |:|...:..|....|..|...:|.|||||:||||::|..|.|||..||:.|:       |...|.
Worm  1018 YRCGLNNPLLGGMSCIHCETPFIISFVSFDILPLIEFKIENDISFDEAKELI-------ESEPPL 1075

  Fly  1082 NEDVASAL--------PLSLDRNGLRAIDPNHVLILKRRGKNVRNVYYRNILPDLQVTYCPQCLL 1138
            ::|..:.|        .:.|:|..|..::..|| |::.....:...:..|::|.:.:..|..|..
Worm  1076 SDDDYNPLRGLKKGIKEIILNRESLSKLEQGHV-IIQTFPPPLAPKFLFNVMPSITIAQCKGCNK 1139

  Fly  1139 LFYAEDFELQVLQKGHCPFCHTSSEK 1164
            :|..:|||:..|:|||||||.||.::
Worm  1140 VFDLDDFEMACLRKGHCPFCRTSYDR 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oseg1	NP_001286982.1	WD40	<8..307	CDD:225201	118/308 (38%)
		WD40	22..296	CDD:295369	110/283 (39%)
		WD40 repeat	25..59	CDD:293791	12/33 (36%)
		WD40 repeat	65..99	CDD:293791	16/33 (48%)
		WD40 repeat	104..136	CDD:293791	15/31 (48%)
		WD40 repeat	144..214	CDD:293791	20/79 (25%)
		WD40 repeat	233..267	CDD:293791	15/33 (45%)
		WD40 repeat	275..301	CDD:293791	13/25 (52%)
		TPR_hemY_coli	<598..789	CDD:273126	64/190 (34%)
daf-10	NP_501591.2	WD40	<22..308	CDD:225201	113/287 (39%)
		WD40	22..303	CDD:295369	110/282 (39%)
		WD40 repeat	22..58	CDD:293791	12/35 (34%)
		WD40 repeat	64..98	CDD:293791	16/33 (48%)
		WD40 repeat	103..135	CDD:293791	15/31 (48%)
		WD40 repeat	141..175	CDD:293791	11/33 (33%)
		WD40 repeat	186..232	CDD:293791	11/45 (24%)
		WD40 repeat	241..275	CDD:293791	15/33 (45%)
		WD40 repeat	282..304	CDD:293791	11/21 (52%)
		TPR_15	590..>731	CDD:290165	59/141 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160160158
Domainoid	1	1.000	658	1.000	Domainoid score	I67
eggNOG	1	0.900	-	-		E2759_KOG1538
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12819
Inparanoid	1	1.050	743	1.000	Inparanoid score	I299
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56394
OrthoDB	1	1.010	-	-		D119591at33208
OrthoFinder	1	1.000	-	-		FOG0007425
OrthoInspector	1	1.000	-	-		oto19420
orthoMCL	1	0.900	-	-		OOG6_104180
Panther	1	1.100	-	-	LDO	PTHR12764
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3289
SonicParanoid	1	1.000	-	-		X5559
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.800