DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oseg1 and ift122

DIOPT Version :9

Sequence 1:	NP_001286982.1	Gene:	Oseg1 / 38957	FlyBaseID:	FBgn0265102	Length:	1169	Species:	Drosophila melanogaster
Sequence 2:	NP_001106492.1	Gene:	ift122 / 100127681	XenbaseID:	XB-GENE-966865	Length:	1189	Species:	Xenopus tropicalis

Alignment Length:	1201	Identity:	560/1201 - (46%)
Similarity:	811/1201 - (67%)	Gaps:	52/1201 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRGVLKWLERIEFPNSKDN-EISVHNVCYAPDGSQLVVAAGDRLLIYDPNDGSLLNTLKAHKDTV 64
            ||.|..|::::   :.:|. |.|::::.:.|||:||:||||:|:|:||.:||:::..||.|||||
Frog     1 MRAVPTWVDKV---HDRDKLEQSIYDLAFKPDGTQLIVAAGNRVLVYDTSDGTMIQPLKGHKDTV 62

  Fly    65 NCVAYSRDGKRFASGASDKMVIVWSPQLEGLLKYSHGDSIQCMSFNPVSHHLASCSLSDFAFWSA 129
            .||||::||||||||::||.||:|:.:|||:|||:|.|||||:|:|||:|.|||||.|||..||.
Frog    63 YCVAYAKDGKRFASGSADKSVIIWTSKLEGILKYTHNDSIQCVSYNPVTHQLASCSSSDFGLWSP 127

  Fly   130 DQKAVQKYKISARVNGCSWTNDGQYLILGLANGTISIRNKLGEEKGRIDRPGGPNSNVFSVQCCP 194
            :||:|.|:|:|:::..||||||||||.||:.||.:|||||.||||.:|:||||..|.::|: |..
Frog   128 EQKSVSKHKVSSKITCCSWTNDGQYLALGMFNGVVSIRNKNGEEKVKIERPGGALSPIWSI-CWN 191

  Fly   195 ASGPGSVDTIGVVDWSQTLSFHTLSGQMIGKERTLGFDPLCLQYFPNGEFCLVGGCTGGLHFFTR 259
            .|.....|.:.|.||.|.|||:.|||:.:||:|.|||||.|:.||..||:.:|.|....:..||:
Frog   192 PSKDDHNDILAVADWGQKLSFYQLSGKQVGKDRVLGFDPCCVSYFSKGEYIIVSGSDKQVSLFTK 256

  Fly   260 EGIRLGTLGDTFDTWIWTVALHPNGQSYTIGCQDGTLACFNIASSTVHALYRERYAFRENMCDVI 324
            :|:|||.:|:. ::|:||..:.|:.....|||||||||.:.:..||||.||::|||:|::|.|||
Frog   257 DGVRLGPIGEQ-NSWVWTCRVKPDSNYVVIGCQDGTLAFYQLIFSTVHGLYKDRYAYRDSMTDVI 320

  Fly   325 IQHLISGQKVRIKCRDLVQKIAIYRNRLAVQLPERVVLYELSSGEDQPMHYKVREKIQQKFDCSL 389
            :||||:.||||||||:||:|||||:||||:|:||::::|||.|.:...|||:|:|||.:||:|:|
Frog   321 VQHLITEQKVRIKCRELVKKIAIYKNRLAIQMPEKILIYELFSDDVNDMHYRVKEKIVKKFECNL 385

  Fly   390 LVVCGRHIVLCQEKRLQCLDFMGVLQREWIMDSFIRYIKVTGGPVGREGLMVGLKNGQVFRIFLN 454
            ||||..||:||||||||||.|.||.:|||:|:|.||||||.|||.|||||:|||||||:.:||::
Frog   386 LVVCSHHIILCQEKRLQCLSFKGVKEREWMMESLIRYIKVIGGPAGREGLLVGLKNGQILKIFVD 450

  Fly   455 NSLPLLITTAVSAVRCLDINSKRSKIAVVDDVGRLVVRDVINDTILYQDTGVNSVTWNTHLDSML 519
            |...:.:....::|||||:::.|:|:||||:....:|.|:....:|:|:...|||.|||..:.||
Frog   451 NPFAITLLKQATSVRCLDMSASRNKLAVVDEHNTCLVYDITTKDLLFQEPNANSVAWNTQCEDML 515

  Fly   520 CYTHTTGG--LSVRVGNLPPRAPQNMHGVVVGLCGATAFCLRGNIMHNTPLALGSTMWQFIEAGL 582
            |:   :||  |:::..|.|.. .|.:.|.|||..|:..|||....|....:...:.|:|::|..:
Frog   516 CF---SGGGYLNIKASNFPVH-QQKLQGFVVGYNGSKIFCLHVYSMSAVEVPQSAPMYQYLERKM 576

  Fly   583 FDEAYQVACLGVTTSDWEGLAQSALEALHINIARDAYVKVRNLPWLKLIGELRDQQQRSAVPKEV 647
            |.||||:||||||..||:.||..|||.|....|:.|:::||:|.:|:||..:.::::|......:
Frog   577 FREAYQIACLGVTDLDWKELAMEALEGLDFETAKKAFIRVRDLRYLELINSIEERKKRGDANDNL 641

  Fly   648 LLAENCAFAGKFKEAARLFLKCGQSSRALEMYTDLRMFDLAQEYIKDGTDQEKKELVRKRAEWAY 712
            .||:..|:.|||.|||:|:.|.||.||||:||||||||:.|:|::..|..::.|.|:.|:|:||.
Frog   642 FLADVFAYQGKFHEAAKLYKKAGQESRALDMYTDLRMFEFAKEFLGSGDPKDTKTLITKQADWAR 706

  Fly   713 SVKEPRAAAELLLSAGENQKAIDIVAEQGWADVLYDIGRRLSLTERDSLESVAQNLKTLKALPLA 777
            :::|||.|||:.||||||.|||::..:.||.|:|.:|.|:|...||:.|...|...|.|:....|
Frog   707 NIREPRTAAEMYLSAGENMKAIELSGDHGWVDMLIEIARKLDKAEREPLLKCAYYFKKLQHHGYA 771

  Fly   778 AEIFKKLGDEAQVVQLHIEVRDWPEAFRLAESLPELLPTVHYQHGQWLAETDQFIEAHQAYIKAG 842
            ||.:.|:||...:|:|::|.:.|.|||.|.|..||....|:..:.|||||.|:|.||.:|:.|||
Frog   772 AETYMKIGDLKALVRLYVETQRWEEAFALVEKNPEYKDEVYIPYAQWLAEHDRFEEAQKAFHKAG 836

  Fly   843 RTKEANRLLKQLSNTAIVEERYLDASYFYWLLAKQHLDVYHAKEEQNPVDHHLTEYKNHLRVAKV 907
            |..||.|:|:||::.|:||.|:.||:|:||:|:.|.|::...|||:.  |..|.::.:...:|::
Frog   837 RQDEAVRVLEQLTHNAVVESRFNDAAYYYWMLSMQCLEISKDKEEKQ--DAMLQKFYHFQHLAEL 899

  Fly   908 YYAYSVIYSYMKEPFTTHSPVSLFNVSRFILNEVEHKGVPKGVSMFSVLFTLAKQAKFLQANKLC 972
            |:.|..|:.|..|||::|.|.:|||:|||:|:.:. |..|.|:|..:.|||||||:|.|.|.||.
Frog   900 YHVYHSIHRYTDEPFSSHLPETLFNISRFLLHSLT-KESPLGISKVNTLFTLAKQSKALGAYKLA 963

  Fly   973 LLINKRLQSLKPPAGVQEQIDLNFLNSKACKSGFNDPEELLPLCYKCSNYSQHLNS--NCCPTCR 1035
            ..:.:|||.|:.|:...|.|:|..:..::  ..|:|.|||:|:||:||..:..||:  |.|..||
Frog   964 RQVYERLQGLRIPSRFLESIELGSITIRS--KPFHDSEELIPMCYRCSTNNPFLNNLGNVCINCR 1026

  Fly  1036 QDYIFSFVSFEILPLVQFYPEVDISDAEAERL--LLAPAKHAE-DS------------------- 1078
            |.::||..|:|:||||:||.|..|||.||..|  |.||...:: ||
Frog  1027 QRFVFSASSYEVLPLVEFYLEDGISDEEAVSLVDLEAPRSSSKADSWREMSSGDTQTLRLDDGDD 1091

  Fly  1079 ----DPFNEDV------ASALPLSLDRNGLRAIDPNHVLILKRRGKNVRNVYYRNILPDLQVTYC 1133
                |||...:      :..:|:.::|..||.:....||| ||....::..|:|::|||:.:|.|
Frog  1092 MMTYDPFTAKLSFEQGGSEFVPVVVNRAVLRTMSRRDVLI-KRWPLPLKWQYFRSLLPDVSITMC 1155

  Fly  1134 PQCLLLFYAEDFELQVLQKGHCPFCHTSSEK 1164
            |.|..:|:.||:||.|||...||:|....|:
Frog  1156 PSCFQMFHTEDYELLVLQHNCCPYCRRPIEE 1186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oseg1	NP_001286982.1	WD40	<8..307	CDD:225201	155/299 (52%)
		WD40	22..296	CDD:295369	148/273 (54%)
		WD40 repeat	25..59	CDD:293791	16/33 (48%)
		WD40 repeat	65..99	CDD:293791	22/33 (67%)
		WD40 repeat	104..136	CDD:293791	21/31 (68%)
		WD40 repeat	144..214	CDD:293791	37/69 (54%)
		WD40 repeat	233..267	CDD:293791	14/33 (42%)
		WD40 repeat	275..301	CDD:293791	12/25 (48%)
		TPR_hemY_coli	<598..789	CDD:273126	85/190 (45%)
ift122	NP_001106492.1	WD 1	16..54		17/37 (46%)
		WD40 repeat	21..57	CDD:293791	16/35 (46%)
		WD40	55..297	CDD:392136	135/243 (56%)
		WD 2	57..97		27/39 (69%)
		WD40 repeat	63..97	CDD:293791	22/33 (67%)
		WD 3	99..135		23/35 (66%)
		WD40 repeat	102..134	CDD:293791	21/31 (68%)
		WD 4	137..175		24/37 (65%)
		WD40 repeat	142..178	CDD:293791	24/35 (69%)
		WD 5	180..223		17/43 (40%)
		WD40 repeat	185..224	CDD:293791	16/39 (41%)
		WD 6	225..264		18/38 (47%)
		WD 7	266..306		17/40 (43%)
		WD40 repeat	267..295	CDD:293791	13/28 (46%)
		WD 8	459..498		14/38 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1005	1.000	Domainoid score	I33
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H12819
Inparanoid	1	1.050	1106	1.000	Inparanoid score	I235
OMA	1	1.010	-	-		QHG56394
OrthoDB	1	1.010	-	-		D119591at33208
OrthoFinder	1	1.000	-	-		FOG0007425
OrthoInspector	1	1.000	-	-		oto103269
Panther	1	1.100	-	-	LDO	PTHR12764
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3289
SonicParanoid	1	1.000	-	-		X5559
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110