DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13667 and mtrr

DIOPT Version :9

Sequence 1:	NP_648220.1	Gene:	CG13667 / 38956	FlyBaseID:	FBgn0035890	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001373459.1	Gene:	mtrr / 560667	ZFINID:	ZDB-GENE-101115-3	Length:	697	Species:	Danio rerio

Alignment Length:	708	Identity:	201/708 - (28%)
Similarity:	313/708 - (44%)	Gaps:	149/708 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LVLYGSQTGTAQDVAEQIWRESHQLGFQGPVLPFDEYDMTKL-IEERLVVFVVATTGDGVEPDNM 67
            |:|||||.|.||.:||:|.:::.:.||...:....::|...| .|.|.|||||:|||||..||..
Zfish    10 LILYGSQRGQAQSIAEEICQQAAEHGFTADISCLSKHDKYNLDSESRPVVFVVSTTGDGDPPDTA 74

  Fly    68 KLAWRFLLKRSLPAQSLQGMQFACLGLGDSSYPKFNYAAKKLSKRLQNLGANSVCPVGLCDDQHD 132
            ....|.:..:|||...|..:::|.|||||::|..|....|.:...||.|||......|..||
Zfish    75 LKFVRKIKNKSLPHDHLSHLRYALLGLGDTNYANFCNGGKTIDSYLQKLGAKHFYATGHADD--- 136

  Fly   133 YGHLGVSLS-----WTKDLWTALK----GISGLDESKLS-----NSHQTT-------------VK 170
                |..|.     |.:.||.|||    .:|..|:..||     ::||..             :|
Zfish   137 ----GTGLEVVVDPWIEGLWDALKKAFSTMSTSDQQTLSDCTQDSNHQNASDQKKNLEVDLQLLK 197

  Fly   171 WSVKELPK------DS----------------QIAPMDNLLWSQKQTAHSF-KIL----DNQRTT 208
            .|..:.||      ||                .:.|:...:.:......|: :||    :|...|
Zfish   198 LSEVDSPKGKTVTSDSIATEIGSTSSVASLKESVPPLSESVLNVPALPPSYLEILLVGTENVEET 262

  Fly   209 ---------------AVDHFQD-----VRFLRLQ-CQTEDLSWEPGDVLDVQPQNSDEAVQTFFD 252
                           ||...||     ...|.|. .|.::..::|||..|:...|.|..|:   :
Zfish   263 VLPDKDGYFEVPISKAVQLTQDDAVKTAILLELDISQQQEQVYQPGDAFDILCPNRDSEVE---E 324

  Fly   253 LIREHSLNFDESTIVEV------SSAHQDMPLPIAYSNPLSLLQAAKFVW--DLSAKPRQRFLEV 309
            |:.:..|...::..|:|      |.....:||.|..:..|..:    ..|  ::.:.|::.||..
Zfish   325 LLLKLDLQMQKNCTVQVNLLKNTSKKAAKVPLHIPQNGSLQFI----LTWCLEIRSTPKKAFLRA 385

  Fly   310 LAQNCCDEMEKEKLLEFSSAEGIDDLVAYVNRPRRNLLEVLEDFRHATSSLTLQQLFEMMPLIQP 374
            |.....:..||.:|||..|.:|..|..::|......:|::|..|......|:|  |||.:|.:||
Zfish   386 LVDFTQNASEKRRLLELCSKQGSADYNSFVRDSSVCVLDLLRAFPSCCPPLSL--LFEHLPKLQP 448

  Fly   375 RSFSIASDVSAL----SLDLLVAVVEYKT-IMHTPRLGLCSNWLKTLKS------GTELSGVVKR 428
            |::|.||  |:|    .:.|:..|||:.. ..|..|.|||:.||....|      ||.|:. .:.
Zfish   449 RAYSAAS--SSLQHPGKVHLVFNVVEFPARPEHPARKGLCTGWLVDHVSSILEPHGTALAS-ERP 510

  Fly   429 GTMVWPK---------------DLSIPLIMVGPGTGIAPFRSIIQNRLYAQ--SKGATIGPLVVF 476
            ||...||               |..:|::|||||||:|||...:|.|...:  ::.||.|.:.:|
Zfish   511 GTSALPKVHVRARPSSTFHLPSDPCVPVVMVGPGTGVAPFIGFLQQREKEREANQEATFGEMWLF 575

  Fly   477 FGCRNKAADFHFGNDFSTWTDAKQVEAH--TAFSRDQ-------DQKVYVQHLIAKNGAHLARLI 532
            ||||:|..||.|..:...:.....: :|  ..||||:       ::..||||.:..:..:||:::
Zfish   576 FGCRHKDKDFLFREELEKFVHNGTL-SHLIVCFSRDEPDAAETVNRPTYVQHNLILHAKNLAKIL 639

  Fly   533 KDLNAYIYVAGNSNNMPKSVKEAFIEILDGDADYVEL--------MIKQRRYQEETWA 582
            .:....:||.|::.||.|.|.:..:||:..:....:|        :.:.:||.::.|:
Zfish   640 LEDKGCLYVCGDAKNMAKDVNDTLLEIIGNELQLDKLDAMKIVAGLREDKRYLQDIWS 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13667	NP_648220.1	CysJ	2..581	CDD:223446	200/705 (28%)
		Flavodoxin_1	5..136	CDD:278677	51/131 (39%)
		FNR_like	200..581	CDD:297884	126/458 (28%)
mtrr	NP_001373459.1	Flavodoxin_1	11..147	CDD:395199	53/142 (37%)
mtrr	NP_001373459.1	methionine_synthase_red	274..696	CDD:99800	122/434 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0369
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53742
OrthoDB	1	1.010	-	-		D318396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.830