DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG13667 and NOS2

DIOPT Version :9

Sequence 1:NP_648220.1 Gene:CG13667 / 38956 FlyBaseID:FBgn0035890 Length:582 Species:Drosophila melanogaster
Sequence 2:NP_000616.3 Gene:NOS2 / 4843 HGNCID:7873 Length:1153 Species:Homo sapiens


Alignment Length:636 Identity:185/636 - (29%)
Similarity:293/636 - (46%) Gaps:103/636 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MRLLVLYGSQTGTAQDVAEQIWRESHQLG------FQGPVLPFDEYDMTKLIEERLVVFVVATTG 59
            :|:.:|:.::||.::.:|   |    .||      |...|:..|:|.::.|.||||::.|.:|.|
Human   537 VRVTILFATETGKSEALA---W----DLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFG 594

  Fly    60 DGVEPDNMKLAWRFLLKRSL-PAQSLQG-MQFACLGLGDSSYPKFNYAAKKLSKRLQNLGANSVC 122
            :|..|.|.:     .||:|| ..:.|.. .::|..|||.|.||:|...|..:.::|.:|||:.:.
Human   595 NGDCPGNGE-----KLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLT 654

  Fly   123 PVGLCDDQHDYGHLGVSLSWTKDLWTA------LKGISGLDESKLSNSHQTTVKWSVK--ELPKD 179
            |:|..|:..  |......||....:.|      ::|...:...||..|:   |.|...  .|.:|
Human   655 PMGEGDELS--GQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSN---VTWDPHHYRLVQD 714

  Fly   180 SQIAPMDNLLWS-QKQTAHSFKILDNQRTTAVDHFQDVRFLRLQCQT-EDLSWEPGDVLDVQPQN 242
            ||...:...|.| ..:...:.::...|...:....:....:.|.|:. :.|::.||:.|.|.|.|
Human   715 SQPLDLSKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGN 779

  Fly   243 SDEAVQ----------TFFDLIREHSLNFDESTIVEVSSAHQDMPLPIAYSNPLSLLQAAKFVWD 297
            ....||          |....:|..:|  |||....||    |..||     |.||.||..:..|
Human   780 QPALVQGILERVVDGPTPHQTVRLEAL--DESGSYWVS----DKRLP-----PCSLSQALTYFLD 833

  Fly   298 LSAKPRQRFLEVLAQNCCDEMEKEKL------LEFSSAEGIDDLVAYVNRPRRNLLEVLEDFRHA 356
            ::..|.|..|:.|||...:|.|:::|      .|:|..:       :.|.|  ..|||||:|   
Human   834 ITTPPTQLLLQKLAQVATEEPERQRLEALCQPSEYSKWK-------FTNSP--TFLEVLEEF--- 886

  Fly   357 TSSLTLQQ--LFEMMPLIQPRSFSIAS--DVSALSLDLLVAVVEYKT------IMHTPRLGLCSN 411
             .||.:..  |...:|:::||.:||:|  |.:...:.|.||||.|.|      :.|    |:||.
Human   887 -PSLRVSAGFLLSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHH----GVCST 946

  Fly   412 WLKTLKSGTELSGVVKRGT-MVWPKDLSIPLIMVGPGTGIAPFRSIIQNRLY-AQSKGATIGPLV 474
            ||.:||....:...|:..: ...|:|.|.|.|::|||||||||||..|.||: :|.||...|.:.
Human   947 WLNSLKPQDPVPCFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMT 1011

  Fly   475 VFFGCRNKAADFHFGNDFSTWTDAKQVEA-HTAFSR-DQDQKVYVQHLIAKN-GAHLARLIKDLN 536
            :.||||....|..:..:.........:.| |||:|| ....|||||.::.:. .:.:.|::....
Human  1012 LVFGCRRPDEDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEP 1076

  Fly   537 AYIYVAGNSNNMPKSVKEAFIEIL--------DGDADYVELMIKQRRYQEE 579
            .::||.|:. .|.:.|.....:::        :...||...:..|:||.|:
Human  1077 GHLYVCGDV-RMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHED 1126

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG13667NP_648220.1 CysJ 2..581 CDD:223446 185/635 (29%)
Flavodoxin_1 5..136 CDD:278677 44/138 (32%)
FNR_like 200..581 CDD:297884 125/420 (30%)
NOS2NP_000616.3 DINNN-motif, mediates interaction with SPSB1, SPSB2 and SPSB4. /evidence=ECO:0000269|PubMed:21199876 23..27
NOS_oxygenase_euk 84..496 CDD:238410
Calmodulin-binding. /evidence=ECO:0000255 509..529
CysJ 538..1127 CDD:223446 185/635 (29%)
Flavodoxin_1 541..672 CDD:278677 44/144 (31%)
FNR_like 736..1132 CDD:297884 125/420 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0369
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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