DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13667 and MTRR

DIOPT Version :9

Sequence 1:	NP_648220.1	Gene:	CG13667 / 38956	FlyBaseID:	FBgn0035890	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_001351369.1	Gene:	MTRR / 4552	HGNCID:	7473	Length:	698	Species:	Homo sapiens

Alignment Length:	718	Identity:	198/718 - (27%)
Similarity:	300/718 - (41%)	Gaps:	159/718 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RLLVLYGSQTGTAQDVAEQIWRESHQLGFQGP---VLPFDEYDMTKLIEERLVVFVVATTGDGVE 63
            |.|:||.:|.|.|:.:||:|..::...||...   :...|:||:.  .|...:|.||:|||.|..
Human     3 RFLLLYATQQGQAKAIAEEICEQAVVHGFSADLHCISESDKYDLK--TETAPLVVVVSTTGTGDP 65

  Fly    64 PDNMKLAWRFLLKRSLPAQSLQGMQFACLGLGDSSYPKFNYAAKKLSKRLQNLGANSVCPVGLCD 128
            ||..:...:.:..::||......:::..||||||.|..|....|.:.||||.|||......|..|
Human    66 PDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTGHAD 130

  Fly   129 DQHDYGHLGVSL---SWTKDLWTALK----------GISG------------------------- 155
            |     .:|:.|   .|...||.||:          .|||
Human   131 D-----CVGLELVVEPWIAGLWPALRKHFRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQ 190

  Fly   156 -----LDES----------KLSNSHQTTV---------KWSVKEL-----------PKDSQIAPM 185
                 .|:|          ...||:|:.|         ..||..|           |:..|:...
Human   191 VELLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQ 255

  Fly   186 DNLLWSQKQTAHS-----FKILDNQ--RTTAVDHFQDVRFLRLQCQTEDLSWEPGDVLDVQPQNS 243
            ::|...:.|.:.:     |::..::  :.|..|..:....:.|.....|.|::|||...|...||
Human   256 ESLGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNS 320

  Fly   244 DEAVQTFFDLI-----REHSLNFDESTIVEVSSAHQDMPLPIAYSNPLSLLQAAKFVW--DLSAK 301
            |..||:....:     |||.:........:...|.....:|...|     ||.. |.|  ::.|.
Human   321 DSEVQSLLQRLQLEDKREHCVLLKIKADTKKKGATLPQHIPAGCS-----LQFI-FTWCLEIRAI 379

  Fly   302 PRQRFLEVLAQNCCDEMEKEKLLEFSSAEGIDDLVAYVNRPRRNLLEVLEDFRHATSSLTLQQLF 366
            |::.||..|.....|..||.:|.|..|.:|..|...:|......||::|..|......|:|  |.
Human   380 PKKAFLRALVDYTSDSAEKRRLQELCSKQGAADYSRFVRDACACLLDLLLAFPSCQPPLSL--LL 442

  Fly   367 EMMPLIQPRSFSIASDVSAL----SLDLLVAVVEYKTIMHTP--RLGLCSNWLKTL--------- 416
            |.:|.:|||.:|.||  |:|    .|..:..:||:.:...|.  |.|:|:.||..|
Human   443 EHLPKLQPRPYSCAS--SSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNI 505

  Fly   417 -----KSGTELS---GVVKRGTMVW--PKDLSIPLIMVGPGTGIAPFRSIIQNR--LYAQSKGAT 469
                 .||..|:   .:..|.|..:  |.|.|||:||||||||||||...:|:|  |..|.....
Human   506 HASHEDSGKALAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGN 570

  Fly   470 IGPLVVFFGCRNKAADFHFGNDFSTW------TDAKQVEAHTAFSRD------QDQKVYVQHLIA 522
            .|.:.:|||||:|..|:.|..:...:      |..|     .:||||      :....|||..|.
Human   571 FGAMWLFFGCRHKDRDYLFRKELRHFLKHGILTHLK-----VSFSRDAPVGEEEAPAKYVQDNIQ 630

  Fly   523 KNGAHLARLIKDLNAYIYVAGNSNNMPKSVKEAFIEILDGDADYVEL--------MIKQRRYQEE 579
            .:|..:||::...|.:|||.|::.||.|.|.:|.::|:..:....:|        :.:::||.::
Human   631 LHGQQVARILLQENGHIYVCGDAKNMAKDVHDALVQIISKEVGVEKLEAMKTLATLKEEKRYLQD 695

  Fly   580 TWA 582
            .|:
Human   696 IWS 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13667	NP_648220.1	CysJ	2..581	CDD:223446	197/715 (28%)
		Flavodoxin_1	5..136	CDD:278677	44/133 (33%)
		FNR_like	200..581	CDD:297884	127/436 (29%)
MTRR	NP_001351369.1	Flavodoxin_1	6..142	CDD:306716	46/142 (32%)
		Hinge	166..247		9/80 (11%)
		methionine_synthase_red	277..697	CDD:99800	127/434 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0369
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53742
OrthoDB	1	1.010	-	-		D318396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.830