DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13667 and Nos2

DIOPT Version :9

Sequence 1:	NP_648220.1	Gene:	CG13667 / 38956	FlyBaseID:	FBgn0035890	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_036743.3	Gene:	Nos2 / 24599	RGDID:	3185	Length:	1147	Species:	Rattus norvegicus

Alignment Length:	661	Identity:	178/661 - (26%)
Similarity:	294/661 - (44%)	Gaps:	153/661 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLLVLYGSQTGTAQDVAEQIWRESHQLGFQGPVLPFDEYDMTKLIEERLVVFVVATTGDGVEPD 65
            :|..||:.::||.::.:|..: .......|...|:..::|....|.||:|::.|.:|.|:|..|.
  Rat   534 VRATVLFATETGKSEALARDL-AALFSYAFNTKVVCMEQYKANTLEEEQLLLVVTSTFGNGDCPS 597

  Fly    66 NMKLAWRFLLKRSLPAQSLQG--MQFACLGLGDSSYPKFNYAAKKLSKRLQNLGANSVCPVGLCD 128
            |.:     .||:||......|  .::|..|||.|.||:|...|..:.::|.:|||:.:.|.|..|
  Rat   598 NGQ-----TLKKSLFMMKELGHTFRYAVFGLGSSMYPQFCAFAHDIDQKLSHLGASQLAPTGEGD 657

  Fly   129 DQHDYGHLGVSLSWTKDLWTALKGISGLDESKLSNSHQTTVKWSVK-----------------EL 176
            :                       :||.:::..|        |:|:                 ::
  Rat   658 E-----------------------LSGQEDAFRS--------WAVQTFRAACETFDVRSKHCIQI 691

  Fly   177 PKDSQIAPMDNLLWSQKQ--TAHSFKILDNQRTTAVDHFQDVRFLRLQ----CQTE--------- 226
            ||    ....|..|..:|  ...|.:.||..:..:..|.::|..:||:    .|:|
  Rat   692 PK----RYTSNATWEPEQYKLTQSPESLDLNKALSSIHAKNVFTMRLKSLQNLQSEKSSRTTLLV 752

  Fly   227 DLSWE--------PGDVLDVQPQNSDEAVQTFFDLIREHSLNFDESTIVEV---SSAH--QDMPL 278
            .|::|        ||:.|.:.|.|....||...:.:.:.| :.|::..:||   |.::  :|..|
  Rat   753 QLTFEGSRGPSYLPGEHLGIFPGNQTALVQGILERVVDCS-SPDQTVCLEVLDESGSYWVKDKRL 816

  Fly   279 PIAYSNPLSLLQAAKFVWDLSAKPRQRFLEVLAQNCCDEMEKEKLLEFSSAEGIDDLVAYVNRPR 343
            |     |.||.||..:..|::..|.|..|..||:...:|..:::|.........:|. .:.|.|
  Rat   817 P-----PCSLRQALTYFLDITTPPTQLQLHKLARFATEETHRQRLEALCQPSEYNDW-KFSNNP- 874

  Fly   344 RNLLEVLEDF---RHATSSLTLQQLFEMMPLIQPRSFSIAS--DVSALSLDLLVAVVEYKT---- 399
             ..|||||:|   |...:.|.||     :|:::||.:||:|  |.:...:.|.||||.|:|
  Rat   875 -TFLEVLEEFPSLRVPAAFLLLQ-----LPILKPRYYSISSSQDHTPSEVHLTVAVVTYRTRDGQ 933

  Fly   400 --IMHTPRLGLCSNWLKTLK------------SGTELSGVVKRGTMVWPKDLSIPLIMVGPGTGI 450
              :.|    |:||.|:..||            ||.:|           |:|.|.|.|::||||||
  Rat   934 GPLHH----GVCSTWINNLKPEDPVPCFVRSVSGFQL-----------PEDPSQPCILIGPGTGI 983

  Fly   451 APFRSIIQNRLY-AQSKGATIGPLVVFFGCRNKAADFHFGNDFSTWTDAKQV--EAHTAFSR-DQ 511
            |||||..|.||: :|.:|...|.:.:.||||:...|..:..:..... .|.|  :.||.:|| ..
  Rat   984 APFRSFWQQRLHDSQHRGLKGGRMTLVFGCRHPEEDHLYQEEMQEMV-RKGVLFQVHTGYSRLPG 1047

  Fly   512 DQKVYVQHLIAKNGA-HLARLIKDLNAYIYVAGN---SNNMPKSVKEAFIEILDGDADYVE---L 569
            ..|||||.::.|..| .:..::.....::||.|:   :.::..::|:.....|:...:.||   .
  Rat  1048 KPKVYVQDILQKELADEVFSVLHGEQGHLYVCGDVRMARDVATTLKKLVAAKLNLSEEQVEDYFF 1112

  Fly   570 MIK-QRRYQEE 579
            .:| |:||.|:
  Rat  1113 QLKSQKRYHED 1123

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13667	NP_648220.1	CysJ	2..581	CDD:223446	178/660 (27%)
		Flavodoxin_1	5..136	CDD:278677	39/132 (30%)
		FNR_like	200..581	CDD:297884	127/441 (29%)
Nos2	NP_036743.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..51
		DINNN-motif, mediates interaction with SPSB1, SPSB2 and SPSB4. /evidence=ECO:0000250\|UniProtKB:P35228	23..27
		NOS_oxygenase_euk	81..493	CDD:238410
		Calmodulin-binding. /evidence=ECO:0000255	506..526
		CysJ	537..1124	CDD:223446	177/658 (27%)
		Flavodoxin_1	538..669	CDD:278677	42/167 (25%)
		FNR_like	733..1129	CDD:297884	123/421 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0369
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810