Protein Alignment CG13667 and Nos2

DIOPT Version :10

• Sequence 1: NP_648220.1
• Gene: CG13667 / 38956
• FlyBaseID: FBgn0035890
• Length: 582
• Species: Drosophila melanogaster
• Sequence 2: NP_036743.4
• Gene: Nos2 / 24599
• RGDID: 3185
• Length: 1147
• Species: Rattus norvegicus
• Alignment Length: 660
• Identity: 177/660 - (26%)
• Similarity: 293/660 - (44%)
• Gaps: 151/660 - (22%)

  Fly     1 MRLLVLYGSQTGTAQDVAEQIWRESHQLGFQGPVLPFDEYDMTKLIEERLVVFVVATTGDGVEPD 65
            :|..||:.::||.::.:|..: .......|...|:..::|....|.||:|::.|.:|.|:|..|.
  Rat   534 VRATVLFATETGKSEALARDL-AALFSYAFNTKVVCMEQYKANTLEEEQLLLVVTSTFGNGDCPS 597

  Fly    66 NMKLAWRFLLKRSLPAQSLQG--MQFACLGLGDSSYPKFNYAAKKLSKRLQNLGANSVCPVGLCD 128
            |.:     .||:||......|  .::|..|||.|.||:|...|..:.::|.:|||:.:.|.|..|
  Rat   598 NGQ-----TLKKSLFMMKELGHTFRYAVFGLGSSMYPQFCAFAHDIDQKLSHLGASQLAPTGEGD 657

  Fly   129 DQHDYGHLGVSLSWTKDLWTALKGISGLDESKLSNSHQTTVKWSVK-----------------EL 176
            :                       :||.:::..|        |:|:                 ::
  Rat   658 E-----------------------LSGQEDAFRS--------WAVQTFRAACETFDVRSKHCIQI 691

  Fly   177 PKDSQIAPMDNLLWSQKQ--TAHSFKILDNQRTTAVDHFQDVRFLRLQ----CQTE--------- 226
            ||    ....|..|..:|  ...|.:.||..:..:..|.::|..:||:    .|:|
  Rat   692 PK----RYTSNATWEPEQYKLTQSPEPLDLNKALSSIHAKNVFTMRLKSLQNLQSEKSSRTTLLV 752

  Fly   227 DLSWE--------PGDVLDVQPQNSDEAVQTFFDLIREHSLNFDESTIVEV---SSAH--QDMPL 278
            .|::|        ||:.|.:.|.|....||...:.:.:.| :.|::..:||   |.::  :|..|
  Rat   753 QLTFEGSRGPSYLPGEHLGIFPGNQTGLVQGILERVVDCS-SPDQTVCLEVLDESGSYWVKDKRL 816

  Fly   279 PIAYSNPLSLLQAAKFVWDLSAKPRQRFLEVLAQNCCDEMEKEKLLEFSSAEGIDDLVAYVNRPR 343
            |     |.||.||..:..|::..|.|..|..||:...:|..:::|.........:|. .:.|.|
  Rat   817 P-----PCSLRQALTYFLDITTPPTQLQLHKLARFATEETHRQRLEALCQPSEYNDW-KFSNNP- 874

  Fly   344 RNLLEVLEDFRHATSSLTLQQLF--EMMPLIQPRSFSIAS--DVSALSLDLLVAVVEYKT----- 399
             ..|||||:|    .||.:...|  ..:|:::||.:||:|  |.:...:.|.||||.|:|
  Rat   875 -TFLEVLEEF----PSLRVPAAFLLSQLPILKPRYYSISSSQDHTPSEVHLTVAVVTYRTRDGQG 934

  Fly   400 -IMHTPRLGLCSNWLKTLK------------SGTELSGVVKRGTMVWPKDLSIPLIMVGPGTGIA 451
             :.|    |:||.|:..||            ||.:|           |:|.|.|.|::|||||||
  Rat   935 PLHH----GVCSTWINNLKPEDPVPCFVRSVSGFQL-----------PEDPSQPCILIGPGTGIA 984

  Fly   452 PFRSIIQNRLY-AQSKGATIGPLVVFFGCRNKAADFHFGNDFSTWTDAKQV--EAHTAFSR-DQD 512
            ||||..|.||: :|.:|...|.:.:.||||:...|..:..:..... .|.|  :.||.:|| ...
  Rat   985 PFRSFWQQRLHDSQHRGLKGGRMTLVFGCRHPEEDHLYQEEMQEMV-RKGVLFQVHTGYSRLPGK 1048

  Fly   513 QKVYVQHLIAKNGA-HLARLIKDLNAYIYVAGN---SNNMPKSVKEAFIEILDGDADYVE---LM 570
            .|||||.::.|..| .:..::.....::||.|:   :.::..::|:.....|:...:.||   ..
  Rat  1049 PKVYVQDILQKELADEVFSVLHGEQGHLYVCGDVRMARDVATTLKKLVAAKLNLSEEQVEDYFFQ 1113

  Fly   571 IK-QRRYQEE 579
            :| |:||.|:
  Rat  1114 LKSQKRYHED 1123

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13667	NP_648220.1	Flavodoxin_1	5..136	CDD:425562	39/132 (30%)
		FNR_like	200..581	CDD:447143	126/440 (29%)
Nos2	NP_036743.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..51
		DINNN-motif, mediates interaction with SPSB1, SPSB2 and SPSB4. /evidence=ECO:0000250|UniProtKB:P35228	23..27
		NOS_oxygenase_euk	81..493	CDD:238410
		Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P35228	512..532
		Flavodoxin_1	538..669	CDD:425562	42/167 (25%)
		FNR_like	733..1129	CDD:447143	122/420 (29%)