DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13667 and Nos1

DIOPT Version :9

Sequence 1:	NP_648220.1	Gene:	CG13667 / 38956	FlyBaseID:	FBgn0035890	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	XP_038944987.1	Gene:	Nos1 / 24598	RGDID:	3184	Length:	1532	Species:	Rattus norvegicus

Alignment Length:	708	Identity:	173/708 - (24%)
Similarity:	293/708 - (41%)	Gaps:	162/708 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLLVLYGSQTGTAQDVAEQIWRESHQLGFQGPVLPFDEYDMTKLIEERLVVFVVATTGDGVEPD 65
            ::..:||.::||.:|..|:.:. |..:..|....:..:|||:..|..|.||:.|.:|.|:|..|:
  Rat   753 VKATILYATETGKSQAYAKTLC-EIFKHAFDAKAMSMEEYDIVHLEHEALVLVVTSTFGNGDPPE 816

  Fly    66 N--------MKL--------------AWRFLLKRSLPAQS------------------------- 83
            |        |::              ..||..::. |:.|
  Rat   817 NGEKFGCALMEMRHPNSVQEERKYPEPLRFFPRKG-PSLSHVDSEAHSLVAARDSQHRSYKVRFN 880

  Fly    84 ---------------------------LQGMQFACLGLGDSSYPKFNYAAKKLSKRLQNLGANSV 121
                                       |..::|:..|||..:||.|......:...|:.||...:
  Rat   881 SVSSYSDSRKSSGDGPDLRDNFESTGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERI 945

  Fly   122 CPV----GLCDDQHDYGHLGVSLSWTKDLWTAL---------KGISGLDESKLSNSHQTTVKWS- 172
            ..:    .||..:..:      .:|.|.::.|.         ..|...:.|.:||..    .|.
  Rat   946 LKMREGDELCGQEEAF------RTWAKKVFKAACDVFCVGDDVNIEKANNSLISNDR----SWKR 1000

  Fly   173 -------VKELPKDSQIAPMDNLLWSQKQTAHSFKILDNQRTTAVDHFQDVRFLRLQCQ-TEDLS 229
                   |.|.|..:|  .:.|:   .|:...:.::|..|...:....:...|:||... .::|.
  Rat  1001 NKFRLTYVAEAPDLTQ--GLSNV---HKKRVSAARLLSRQNLQSPKSSRSTIFVRLHTNGNQELQ 1060

  Fly   230 WEPGDVLDVQPQNSDEAVQTFFD----------LIREHSLNFDESTIVEVSSAHQDMPLPIAYSN 284
            ::|||.|.|.|.|.::.|....:          :::...|....:.:..:|:...:..||
  Rat  1061 YQPGDHLGVFPGNHEDLVNALIERLEDAPPANHVVKVEMLEERNTALGVISNWKDESRLP----- 1120

  Fly   285 PLSLLQAAKFVWDLSAKPRQRFLEVLAQNCCDEMEKEKLLEFSSAEGIDDLVAYVNRPRRNLLEV 349
            |.::.||.|:..|::..|....|:..|....:|.||::||..|  :|:.:...:.......::||
  Rat  1121 PCTIFQAFKYYLDITTPPTPLQLQQFASLATNEKEKQRLLVLS--KGLQEYEEWKWGKNPTMVEV 1183

  Fly   350 LEDFRHATSSLTLQQLFEMMPLIQPRSFSIAS--DVSALSLDLLVAVVEYKT------IMHTPRL 406
            ||:|.......||  |...:.|:|||.:||:|  |:....:.|.||:|.|.|      :.|
  Rat  1184 LEEFPSIQMPATL--LLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYHTRDGEGPVHH---- 1242

  Fly   407 GLCSNWLKTLKSGTELSGVVKRGTMVW--PKDLSIPLIMVGPGTGIAPFRSIIQNRLY-AQSKGA 468
            |:||:||..:::...:...| ||...:  |::..:|.|:||||||||||||..|.|.: .|.||.
  Rat  1243 GVCSSWLNRIQADDVVPCFV-RGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGM 1306

  Fly   469 TIGPLVVFFGCRNKAADFHFGNDFSTWTDAKQV--EAHTAFSRDQDQ-KVYVQHLIAKNGAH-LA 529
            ...|:|:.||||....| |...:.:.....|.|  |.:||:||:.|: |.|||.::.:..|. :.
  Rat  1307 NPCPMVLVFGCRQSKID-HIYREETLQAKNKGVFRELYTAYSREPDRPKKYVQDVLQEQLAESVY 1370

  Fly   530 RLIKDLNAYIYVAGNSNNMPKSVKEAFIEIL-------DGDAD-YVELMIKQRRYQEE 579
            |.:|:...:|||.|:. .|...|.:|...|:       :.||. ::..:....||.|:
  Rat  1371 RALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSEEDAGVFISRLRDDNRYHED 1427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13667	NP_648220.1	CysJ	2..581	CDD:223446	173/707 (24%)
		Flavodoxin_1	5..136	CDD:278677	39/208 (19%)
		FNR_like	200..581	CDD:297884	120/414 (29%)
Nos1	XP_038944987.1	PDZ_signaling	15..98	CDD:238492
		NOS_oxygenase_euk	300..711	CDD:238410
		Flavodoxin_1	757..964	CDD:395199	39/214 (18%)
		Nitric_oxide_synthase	1030..1433	CDD:99799	120/414 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910