DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13667 and Nos2

DIOPT Version :9

Sequence 1:	NP_648220.1	Gene:	CG13667 / 38956	FlyBaseID:	FBgn0035890	Length:	582	Species:	Drosophila melanogaster
Sequence 2:	NP_035057.1	Gene:	Nos2 / 18126	MGIID:	97361	Length:	1144	Species:	Mus musculus

Alignment Length:	652	Identity:	175/652 - (26%)
Similarity:	289/652 - (44%)	Gaps:	135/652 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRLLVLYGSQTGTAQDVAEQIWRESHQLGFQGPVLPFDEYDMTKLIEERLVVFVVATTGDGVEPD 65
            :|..||:.::||.::.:|..: .......|...|:..|:|..:.|.||:|::.|.:|.|:|..|.
Mouse   531 VRATVLFATETGKSEALARDL-ATLFSYAFNTKVVCMDQYKASTLEEEQLLLVVTSTFGNGDCPS 594

  Fly    66 NMKLAWRFLLKRSL--PAQSLQGMQFACLGLGDSSYPKFNYAAKKLSKRLQNLGANSVCPVGLCD 128
            |.:     .||:||  ..:.....::|..|||.|.||:|...|..:.::|.:|||:.:.|.|..|
Mouse   595 NGQ-----TLKKSLFMLRELNHTFRYAVFGLGSSMYPQFCAFAHDIDQKLSHLGASQLAPTGEGD 654

  Fly   129 DQHDYGHLGVSLSWTKDL---WTALKGISGLDESKLSNSHQTTVKWSVKELPKDSQIAPMDNLLW 190
            :          ||..:|.   |......:..:...:.:.|..       ::||..    ..|..|
Mouse   655 E----------LSGQEDAFRSWAVQTFRAACETFDVRSKHHI-------QIPKRF----TSNATW 698

  Fly   191 SQKQ--TAHSFKILDNQRTTAVDHFQDVRFLRLQCQTE-------------DLSWE--------P 232
            ..:|  ...|.:.||..|..:..|.::|..:||:.|..             .|::|        |
Mouse   699 EPQQYRLIQSPEPLDLNRALSSIHAKNVFTMRLKSQQNLQSEKSSRTTLLVQLTFEGSRGPSYLP 763

  Fly   233 GDVLDVQPQNSDEAVQTFFDLIREHSLNFDESTIVEVSSAHQDMPLPIAYSN-----------PL 286
            |:.|.:.|.|....||...:            .:|:..:.||.:.|.:...:           |.
Mouse   764 GEHLGIFPGNQTALVQGILE------------RVVDCPTPHQTVCLEVLDESGSYWVKDKRLPPC 816

  Fly   287 SLLQAAKFVWDLSAKPRQRFLEVLAQNCCDEMEKEKLLEFSSAEGIDDLVAYVNRPRRNLLEVLE 351
            ||.||..:..|::..|.|..|..||:...||.::::|.........:|. .:.|.|  ..|||||
Mouse   817 SLSQALTYFLDITTPPTQLQLHKLARFATDETDRQRLEALCQPSEYNDW-KFSNNP--TFLEVLE 878

  Fly   352 DF--RHATSSLTLQQLFEMMPLIQPRSFSIAS--DVSALSLDLLVAVVEYKT------IMHTPRL 406
            :|  .|..::..|.||    |:::||.:||:|  |.:...:.|.||||.|:|      :.|
Mouse   879 EFPSLHVPAAFLLSQL----PILKPRYYSISSSQDHTPSEVHLTVAVVTYRTRDGQGPLHH---- 935

  Fly   407 GLCSNWLKTLK------------SGTELSGVVKRGTMVWPKDLSIPLIMVGPGTGIAPFRSIIQN 459
            |:||.|::.||            ||.:|           |:|.|.|.|::|||||||||||..|.
Mouse   936 GVCSTWIRNLKPQDPVPCFVRSVSGFQL-----------PEDPSQPCILIGPGTGIAPFRSFWQQ 989

  Fly   460 RLY-AQSKGATIGPLVVFFGCRNKAADFHFGNDFSTWTDAKQV--EAHTAFSR-DQDQKVYVQHL 520
            ||: :|.||...|.:.:.||||:...|..:..:..... .|:|  :.||.:|| ....|||||.:
Mouse   990 RLHDSQHKGLKGGRMSLVFGCRHPEEDHLYQEEMQEMV-RKRVLFQVHTGYSRLPGKPKVYVQDI 1053

  Fly   521 IAKNGAH-LARLIKDLNAYIYVAGN---SNNMPKSVKEAFIEILDGDADYVE---LMIK-QRRYQ 577
            :.|..|: :..::.....::|:.|:   :.::..::|:.....|:...:.||   ..:| |:||.
Mouse  1054 LQKQLANEVLSVLHGEQGHLYICGDVRMARDVATTLKKLVATKLNLSEEQVEDYFFQLKSQKRYH 1118

  Fly   578 EE 579
            |:
Mouse  1119 ED 1120

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13667	NP_648220.1	CysJ	2..581	CDD:223446	175/651 (27%)
		Flavodoxin_1	5..136	CDD:278677	39/132 (30%)
		FNR_like	200..581	CDD:297884	124/446 (28%)
Nos2	NP_035057.1	DINNN-motif, mediates interaction with SPSB1, SPSB2 and SPSB4. /evidence=ECO:0000269\|PubMed:20603330	23..27
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	37..59
		NOS_oxygenase_euk	78..490	CDD:238410
		Calmodulin-binding. /evidence=ECO:0000255	503..523
		CysJ	534..1121	CDD:223446	174/649 (27%)
		Flavodoxin_1	535..666	CDD:278677	42/146 (29%)
		FNR_like	730..1126	CDD:297884	119/426 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0369
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810