Protein Alignment mkg-p and TUT7

DIOPT Version :10

• Sequence 1: NP_648219.1
• Gene: mkg-p / 38955
• FlyBaseID: FBgn0035889
• Length: 659
• Species: Drosophila melanogaster
• Sequence 2: XP_011517313.1
• Gene: TUT7 / 79670
• HGNCID: 25817
• Length: 1551
• Species: Homo sapiens
• Alignment Length: 484
• Identity: 98/484 - (20%)
• Similarity: 170/484 - (35%)
• Gaps: 154/484 - (31%)

  Fly   107 HVRNCIEKEMRGRVRVFP------FGSLVTGLALKESDIDLFLEPNGNQPP--LFHNQLYNKTSH 163
            |:|..:|..:|   :.||      |||...|...|:||:|:.:..||.:..  |...:...:.:.
Human  1024 HIRQNLESFIR---QDFPGTKLSLFGSSKNGFGFKQSDLDVCMTINGLETAEGLDCVRTIEELAR 1085

  Fly   164 FLRRSKCFADVFTIRHASVPIIRCKHQLTGLNIDINMSNPNSIYNSRFVGELMFRNERIRELCLF 228
            .||:.....::..|..|.|||::..|..:||.:||::.|..:::|:|.:......:.|::.||..
Human  1086 VLRKHSGLRNILPITTAKVPIVKFFHLRSGLEVDISLYNTLALHNTRLLSAYSAIDPRVKYLCYT 1150

  Fly   229 LKIWAKKLKL--ISHGGMTSYCLISLIIVNLQVNRLVPSVKELQSLC-----PPVILSGVNYAYS 286
            :|::.|...:  .|.|.::||....:::..|| .|..|.:..||.:.     |.:.:.|.| .|.
Human  1151 MKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQ-QRNPPVIPVLQEIYKGEKKPEIFVDGWN-IYF 1213

  Fly   287 LDLTPPIPARLTT------------LDLLKNFFIYYCTVNFD----------KSVLSPFLGGCVD 329
            .|....:|...:.            |.||:     :.|..||          ||:|:.|     .
Human  1214 FDQIDELPTYWSECGKNTESVGQLWLGLLR-----FYTEEFDFKEHVISIRRKSLLTTF-----K 1268

  Fly   330 KETTLGMPGGFPEYDEQQKLVHDAIGAPPDAFQLDRAMCVQDPFELSRNVAKSVSISNLCYFRQC 394
            |:.|                              .:.:.::|||:|:.|:...:|.....:..:.
Human  1269 KQWT------------------------------SKYIVIEDPFDLNHNLGAGLSRKMTNFIMKA 1303

  Fly   395 LVLAAQACS------DQELTSQPEKLYDYLLFGLADKLVADKIVADKRSERATPRKQQKIENAHV 453
            .:...:...      .::..|:.|..:|      .|.|...::..:.|..|
Human  1304 FINGRRVFGIPVKGFPKDYPSKMEYFFD------PDVLTEGELAPNDRCCR-------------- 1348

  Fly   454 QPPIVDETQETKVAEVGVCGTPPLVRSHVITPTTNDVKCLRSIVLVKNTENDQSIYYYWLICYVD 518
                             :||.        |.....|....|.:    ....||
Human  1349 -----------------ICGK--------IGHFMKDCPMRRKV----RRRRDQ------------ 1372

  Fly   519 TIKDVLTQLYALNVELKESKEPK--HYKW 545
              :|.|.|.|..|.| |.|||.|  |.|:
Human  1373 --EDALNQRYPENKE-KRSKEDKEIHNKY 1398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mkg-p	NP_648219.1	NT_PAP_TUTase	104..216	CDD:143392	32/116 (28%)
TUT7	XP_011517313.1	TUTase	194..411	CDD:465974
		PAP_assoc	550..599	CDD:427532
		TRF4	979..>1310	CDD:227585	71/330 (22%)
		ZnF_C2HC	1346..1361	CDD:197667	5/53 (9%)
		TUTF7_u4	1371..1450	CDD:465208	15/43 (35%)
		ZnF_C2HC	1452..1468	CDD:197667