DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mkg-p and TUT7

DIOPT Version :9

Sequence 1:	NP_001286981.1	Gene:	mkg-p / 38955	FlyBaseID:	FBgn0035889	Length:	659	Species:	Drosophila melanogaster
Sequence 2:	XP_011517313.1	Gene:	TUT7 / 79670	HGNCID:	25817	Length:	1551	Species:	Homo sapiens

Alignment Length:	484	Identity:	98/484 - (20%)
Similarity:	170/484 - (35%)	Gaps:	154/484 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 HVRNCIEKEMRGRVRVFP------FGSLVTGLALKESDIDLFLEPNGNQPP--LFHNQLYNKTSH 163
            |:|..:|..:|   :.||      |||...|...|:||:|:.:..||.:..  |...:...:.:.
Human  1024 HIRQNLESFIR---QDFPGTKLSLFGSSKNGFGFKQSDLDVCMTINGLETAEGLDCVRTIEELAR 1085

  Fly   164 FLRRSKCFADVFTIRHASVPIIRCKHQLTGLNIDINMSNPNSIYNSRFVGELMFRNERIRELCLF 228
            .||:.....::..|..|.|||::..|..:||.:||::.|..:::|:|.:......:.|::.||..
Human  1086 VLRKHSGLRNILPITTAKVPIVKFFHLRSGLEVDISLYNTLALHNTRLLSAYSAIDPRVKYLCYT 1150

  Fly   229 LKIWAKKLKL--ISHGGMTSYCLISLIIVNLQVNRLVPSVKELQSLC-----PPVILSGVNYAYS 286
            :|::.|...:  .|.|.::||....:::..|| .|..|.:..||.:.     |.:.:.|.| .|.
Human  1151 MKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQ-QRNPPVIPVLQEIYKGEKKPEIFVDGWN-IYF 1213

  Fly   287 LDLTPPIPARLTT------------LDLLKNFFIYYCTVNFD----------KSVLSPFLGGCVD 329
            .|....:|...:.            |.||:     :.|..||          ||:|:.|     .
Human  1214 FDQIDELPTYWSECGKNTESVGQLWLGLLR-----FYTEEFDFKEHVISIRRKSLLTTF-----K 1268

  Fly   330 KETTLGMPGGFPEYDEQQKLVHDAIGAPPDAFQLDRAMCVQDPFELSRNVAKSVSISNLCYFRQC 394
            |:.|                              .:.:.::|||:|:.|:...:|.....:..:.
Human  1269 KQWT------------------------------SKYIVIEDPFDLNHNLGAGLSRKMTNFIMKA 1303

  Fly   395 LVLAAQACS------DQELTSQPEKLYDYLLFGLADKLVADKIVADKRSERATPRKQQKIENAHV 453
            .:...:...      .::..|:.|..:|      .|.|...::..:.|..|
Human  1304 FINGRRVFGIPVKGFPKDYPSKMEYFFD------PDVLTEGELAPNDRCCR-------------- 1348

  Fly   454 QPPIVDETQETKVAEVGVCGTPPLVRSHVITPTTNDVKCLRSIVLVKNTENDQSIYYYWLICYVD 518
                             :||.        |.....|....|.:    ....||
Human  1349 -----------------ICGK--------IGHFMKDCPMRRKV----RRRRDQ------------ 1372

  Fly   519 TIKDVLTQLYALNVELKESKEPK--HYKW 545
              :|.|.|.|..|.| |.|||.|  |.|:
Human  1373 --EDALNQRYPENKE-KRSKEDKEIHNKY 1398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mkg-p	NP_001286981.1	NT_PAP_TUTase	104..216	CDD:143392	32/116 (28%)
TUT7	XP_011517313.1	NT_PAP_TUTase	315..427	CDD:143392
		PAP_assoc	550..599	CDD:281779
		NT_PAP_TUTase	1021..1138	CDD:143392	32/116 (28%)
		PAP_assoc	1233..1286	CDD:281779	16/92 (17%)
		TUTF7_u4	1371..1450	CDD:293237	15/43 (35%)
		ZnF_C2HC	1452..1468	CDD:197667
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12271
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910