DRSC/TRiP Functional Genomics Resources

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Protein Alignment mkg-p and Tut1

DIOPT Version :9

Sequence 1:NP_001286981.1 Gene:mkg-p / 38955 FlyBaseID:FBgn0035889 Length:659 Species:Drosophila melanogaster
Sequence 2:NP_932110.1 Gene:Tut1 / 70044 MGIID:1917294 Length:869 Species:Mus musculus


Alignment Length:842 Identity:173/842 - (20%)
Similarity:283/842 - (33%) Gaps:307/842 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    32 MQDCLAHELI----KHA-------SKPQKQLRQRLNAITKLFNSAQSQSER------QELREAL- 78
            |.|..|.|.:    ||:       .:|::|         |.|.|..|:|.:      .:|.:|| 
Mouse    99 MGDISAREAVLSQPKHSLGGHGLRVRPREQ---------KEFQSPASKSPKGVDSSSHQLVQALA 154

  Fly    79 EWSESGGHLCTVLNFFACDLENMKTCFGHVRNCIEKEMR--------GRVRVFPFGSLVTGLALK 135
            |.::.|..:..::     :|..:......:||.:...|:        |.| |.||||.|....:.
Mouse   155 EAADVGAQMVKLV-----ELRELSEAERQLRNLVVALMQEVFTEFFPGCV-VHPFGSTVNSFDVH 213

  Fly   136 ESDIDLFL--------EPNGNQP------------------------------------------ 150
            ..|:||||        ||:...|                                          
Mouse   214 GCDLDLFLDMGDMEETEPDPKAPKVPETSSLDSALASSLDPQALACTPASPLDSLSPTSVQESES 278

  Fly   151 ---------------------------------PLFHNQLYNKTSHFLRRSK------------- 169
                                             ||..::...|....|..::             
Mouse   279 LDFDTPSSLAPQTPDSALGSDTVTSPQSLPPVSPLQEDRKEGKQGKELELAEEASKDEKEEAAAV 343

  Fly   170 ----------CFADVF---TIRHASVPIIRCKHQLTGLNIDINMSNPNSIYNSRFVGELMFRNER 221
                      |...|:   |:..|..|:::..|:.:||:.|:::||..::|||||:......:.|
Mouse   344 LELVGSILRGCVPGVYRVQTVPSARRPVVKFCHRPSGLHGDVSLSNRLALYNSRFLNLCSEMDGR 408

  Fly   222 IRELCLFLKIWAKKLKLISHGG--MTSYCLISLIIVNLQVN--RLVPSVKELQSLC---PPVILS 279
            :|.|...|:.||:...| |.||  :.:|.|..|:|..||..  .::|:|.:|....   ..|.:.
Mouse   409 VRPLVYTLRCWAQHNGL-SGGGPLLNNYALTLLVIYFLQTRDPPVLPTVAQLTQRAGEGEQVEVD 472

  Fly   280 GVNYAYSLDLTPPIPARLTTLDLLKNFFIYYCTVNFDKSVLSPFLGGCVDKETTLGMPGGFPEYD 344
            |.:.::..|.:...|:  |.::.|             .|:|:.|. .||   :.|.:.|......
Mouse   473 GWDCSFPKDASRLEPS--TNVEPL-------------SSLLAQFF-SCV---SCLDLSGSLLSLR 518

  Fly   345 EQQKLVHDAIGAPPDAFQLDR--AMCVQDPFELSRNVAKSVSISNLCYFRQCLVLAAQACSDQEL 407
            |.:.|: .|.|.|.|.::..|  .|.:||||:||.|||.:|:.......:.|...||..|...:.
Mouse   519 EGRPLM-VAEGLPSDLWEGLRLGPMNLQDPFDLSHNVAANVTGRVAKRLQSCCGAAASYCRSLQY 582

  Fly   408 TSQPEKLYDYLLFGLADKLVADKIVADK--------------------------RSERATPRKQQ 446
            ..:..:..|:.|..|........:::.|                          ..|:.|  |::
Mouse   583 QQRSSRGRDWGLLPLLQPSSPSSLLSAKLIPLPSAPFPQVIMALVDVLREALGCHIEQGT--KRR 645

  Fly   447 KIENAHVQ-PPI--VDETQ----------ETKVAEVGVCGTPPLVRSHVITPTTNDVKCLRSIVL 498
            :.|.|.:: .|:  |::.|          |.|....|..|      .|    :.|:|:  ..::.
Mouse   646 RSEGARIKDSPLGGVNKRQRLGGQEKSFEEGKEEPQGCAG------DH----SENEVE--EMVIE 698

  Fly   499 VKNTENDQSIYYYWLICYVDTIKDVLTQLYA-----------LNVEL----------KESKEPKH 542
            |:.|..|      |.:.:....::.|..:.|           :..|:          ||:..|..
Mouse   699 VRETPQD------WALLHSGPPEEELPLMTANCLDKAAEHNPMKPEVAGEGSQGETGKEASHPSS 757

  Fly   543 YKWLISISYDTWTGRSFQRGAGQSFFAHQLQQTIEFTKTRMGNP-----------QYAVNLRG-- 594
            ..|..::.:..|.||...|...|       |||.|..:   |.|           :....|:|  
Mouse   758 VSWRCALWHQVWQGRRRARRRLQ-------QQTKEEGR---GGPTTGAEWLAMEARVTQELKGPN 812

  Fly   595 ----------YFTLQASEDYKELRLDVQPLQGDLLG--------LQRNSPLTRLFKAFKNLL 638
                      ..:..||....|..|.|.||| |..|        ||...|     :|.||||
Mouse   813 SEQERPPGEPLLSFVASASQAEQTLTVAPLQ-DSQGLFPGLHHFLQGFIP-----QALKNLL 868

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mkg-pNP_001286981.1 NT_PAP_TUTase 104..216 CDD:143392 39/228 (17%)
Tut1NP_932110.1 ZnF_U1 14..47 CDD:197732
RRM_TUT1 54..127 CDD:240725 7/27 (26%)
RRM <56..>140 CDD:223796 13/49 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..144 8/38 (21%)
NT_PAP_TUTase 179..403 CDD:143392 39/224 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..247 3/20 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 259..335 4/75 (5%)
KA1, binds the bulging loops of U6 snRNA but is dispensable for terminal uridylyltransferase activity. /evidence=ECO:0000250|UniProtKB:Q9H6E5 601..869 58/304 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 640..689 12/60 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 735..757 4/21 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 775..796 8/30 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 803..822 2/18 (11%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5260
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2580
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
54.770

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