DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mkg-p and tut1

DIOPT Version :9

Sequence 1:	NP_001286981.1	Gene:	mkg-p / 38955	FlyBaseID:	FBgn0035889	Length:	659	Species:	Drosophila melanogaster
Sequence 2:	NP_001025359.1	Gene:	tut1 / 564388	ZFINID:	ZDB-GENE-050706-68	Length:	797	Species:	Danio rerio

Alignment Length:	677	Identity:	157/677 - (23%)
Similarity:	266/677 - (39%)	Gaps:	158/677 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 KHASKPQKQLRQRLNAITKL-FNSAQSQSERQELREALEWSESGGHLCTVLNFFACDLENMKTCF 105
            |.||:.::..:..|.::.|| |...::.|..:::::.:|..|...:...|.:.....|:.:.|.|
Zfish   130 KLASRGKQDCKNTLISLDKLNFELCKAMSVNEQIQKVVESLELKDNEKKVRDLLVQLLQEVFTEF 194

  Fly   106 GHVRNCIEKEMRGRVRVFPFGSLVTGLALKESDIDLFL---------------EPNG-NQPPLFH 154
              ..:|         ::.||||.|....|...|:||||               |..| ||.....
Zfish   195 --FPDC---------QIVPFGSSVNTFGLHSCDLDLFLDLENTKVFQARAKSSEQTGENQSEDCR 248

  Fly   155 N----------------QLYNKTSHFLRRSKCFADVFTIR---HASVPIIRCKHQLTGLNIDINM 200
            :                ::....:..||  ||...|..::   .|.:|:::..|:...|..||.:
Zfish   249 SEDSILSDIDLSTASPAEILELVAVILR--KCVPGVHKVQALSTARLPVVKFSHKELNLQGDITI 311

  Fly   201 SNPNSIYNSRFVGELMFRNERIRELCLFLKIWAKKLKL---ISHGG--MTSYCLISLIIVNLQVN 260
            :|..::.|::|:......:.|:|.|...:::|||:.:|   :|..|  :.:|.|..|:|..|| |
Zfish   312 NNRLAVRNTKFLQLCSGIDSRLRPLVYTIRLWAKQKQLAGNLSGPGPLLNNYALTLLVIFFLQ-N 375

  Fly   261 R---LVPSVKELQSLCPPVILSGVNYAYSLDLTPP-----IPARLTTLD---LLKNFFIYYCTVN 314
            |   ::|||.:|:::........:.   ..|.|.|     :|....|.|   ||..||.:|...:
Zfish   376 RDPPVLPSVNQLKNMACEEEECAIE---EWDCTFPSQPFSVPPSKNTEDLCTLLFGFFTFYSKFD 437

  Fly   315 FDKSVLSPFLGGCVDKETTLGMPGGFPEYDEQQKLVHDAIGAPPDAFQLDR--AMCVQDPFELSR 377
            |..||:| ...|.|...|      .|.:.|.:.....||....|......|  .|.|.|||||:.
Zfish   438 FPASVVS-LRDGHVLPIT------DFLKSDMEALKTADASSPKPKRSSAPRLGPMNVLDPFELNH 495

  Fly   378 NVAKSVSISNLCYFRQCLVLAAQACSDQELTSQPEKLYDYLLFGLADKLVADKIVADKRSERATP 442
            |||.:::......|::....|.:.|...:...:..|...:   ||. :|.|.:..|...|:   |
Zfish   496 NVAGNLNERTQKNFKRECCEAEKYCRSLQYQRKSAKGKSW---GLV-RLFAPQSEAAASSQ---P 553

  Fly   443 RKQQKIE-NAHVQPPIVDETQETKVAEVG----------VCGTPPLVRSHVI--TPTTN------ 488
            |.::.:| :...:|..:.|:...::|..|          ||.....|.:.::  :||..
Zfish   554 RAEKVLEVSVPFKPASLPESLRAQLASAGKDFRGLWFAEVCSAVQKVFNEILQCSPTEETQSLDK 618

  Fly   489 --------DVKCLRSI----VLVK---------NTENDQSIYYYWLICYVDTIKDVLTQLYALNV 532
                    :|...||:    :.||         :.|...|.:         ||.....|  .|:|
Zfish   619 TDKSGSEMEVNNNRSLEDTNIQVKGEAGKKRPLSVEEGPSTF---------TITQAKRQ--RLDV 672

  Fly   533 ELKESKEPKHYKWLISISYDTWTGRSFQRGAGQSFFAHQLQQTI-EFTKTRMGNPQYAVNLRGYF 596
            :| |..||.|:         |||.|| :..||:......|.:|. |.:|...|    .|::....
Zfish   673 DL-EHPEPLHW---------TWTQRS-RVWAGRRKVRRDLLKTSDEASKPEGG----CVDMESRV 722

  Fly   597 TLQASE------DYKELRLDVQPLQGD 617
            |....|      |..|.::|.:.:.|:
Zfish   723 TQSIVEKEEKLHDALEFKVDAEVVGGN 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mkg-p	NP_001286981.1	NT_PAP_TUTase	104..216	CDD:143392	31/146 (21%)
tut1	NP_001025359.1	ZnF_U1	11..>38	CDD:197732
		C2H2 Zn finger	16..38	CDD:275371
		RRM	<47..>134	CDD:223796	2/3 (67%)
		RRM_TUT1	52..125	CDD:240725
		NT_PAP_TUTase	179..327	CDD:143392	34/160 (21%)
		PAP_assoc	421..495	CDD:281779	26/80 (33%)
		KA1, binds the bulging loops of U6 snRNA but is dispensable for terminal uridylyltransferase activity. /evidence=ECO:0000250\|UniProtKB:Q9H6E5	544..787		50/235 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..659		6/47 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2580
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.770