DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mkg-p and mtpap

DIOPT Version :9

Sequence 1:	NP_001286981.1	Gene:	mkg-p / 38955	FlyBaseID:	FBgn0035889	Length:	659	Species:	Drosophila melanogaster
Sequence 2:	XP_021335997.1	Gene:	mtpap / 563801	ZFINID:	ZDB-GENE-101208-3	Length:	600	Species:	Danio rerio

Alignment Length:	461	Identity:	107/461 - (23%)
Similarity:	177/461 - (38%)	Gaps:	119/461 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 APASESTSPPG-DGDGNLVLCMVCAAPFRSMQDCLAHELIKHASKPQKQLRQR----LNAITKLF 62
            |...|||..|. |.:        .|.||:|....|....|:.::.|....:::    :..||.|.
Zfish   140 ASLKESTGIPAVDHE--------AAVPFKSRLLSLKWPGIQSSNYPTPNFKEQSPPNIGDITNLL 196

  Fly    63 NSAQSQSER-QELREALEWSESGGHLCTVLNFFACDLENMKTCFGHVR-----NCIEKEMRGRVR 121
            ....|..|: |.|.|.|:.:|..    ..|.|..|.|      .|.:.     .||
Zfish   197 LQKHSVDEQLQCLTETLQLTEEN----ISLRFLVCSL------LGDIAGAYFPECI--------- 242

  Fly   122 VFPFGSLVTGLALKESDIDLFL---------EPNGNQPPLFHNQLYNKTSHFLRRS------KCF 171
            :.||||.|........|:|:.|         :..|:...|.:......:...:.:|      ||
Zfish   243 IRPFGSTVNSFGKLGCDVDMILDLDGIYARSQKKGSGLSLEYQVKTGPSERAVTQSILSVVGKC- 306

  Fly   172 ADVF--------TIRHASVPIIRCKHQLTGLNIDINMSNPNSIYNSRFVGELMF----RNERIRE 224
            .|.|        .|..|..||:|..||.:|...|:..:|..::.:|    ||:|    .:.|:|.
Zfish   307 VDQFGPGCVGVQNILQARCPIVRFAHQPSGFQCDLTANNKVAMKSS----ELLFLYGHLDPRVRH 367

  Fly   225 LCLFLKIWAKKLKLISH---GGMTSYCLISLIIVNLQVN--RLVPSVKELQSLCPP---VILSGV 281
            |...::.||:...:.|.   ..:|::.|..:::..||..  .::|::..|:.|..|   .::.|.
Zfish   368 LVFSVRCWARAHSITSSIPGAWITNFSLTVMVVFFLQQRSPAMLPTLDRLKELAGPSDKCVIEGN 432

  Fly   282 NYAYSLDLTP-PIPARLTTLD-LLKNFFIYYCTVNFDKSVLSPFLGGCVDKETTLGMPGGFPEYD 344
            :.....||:. .:.....||: ||:.||.:|....|:|:.::...|                  .
Zfish   433 DCTIVSDLSKIALQKNTDTLEKLLQEFFEFYGNFPFNKASINIRKG------------------K 479

  Fly   345 EQQKLVHDAIGAPPDAFQLDRAMCVQDPFELSRNVAKSVSISNLCYFRQCLVLAAQACSDQE-LT 408
            ||.|         |:|    .|:.:|:|||.:.||:|:|:.:.|..|       .:.|.:.. |.
Zfish   480 EQSK---------PEA----AALHIQNPFEATLNVSKNVNAAQLERF-------VKLCQESAWLF 524

  Fly   409 SQPEKL 414
            .|.|.|
Zfish   525 QQKENL 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mkg-p	NP_001286981.1	NT_PAP_TUTase	104..216	CDD:143392	30/139 (22%)
mtpap	XP_021335997.1	RRM_SF	89..>139	CDD:327398
		PAP_assoc	206..>511	CDD:332051	82/359 (23%)
		NT_PAP_TUTase	222..359	CDD:143392	36/156 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	3	2.770