DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mkg-p and Tut7

DIOPT Version :9

Sequence 1:	NP_001286981.1	Gene:	mkg-p / 38955	FlyBaseID:	FBgn0035889	Length:	659	Species:	Drosophila melanogaster
Sequence 2:	XP_006253593.1	Gene:	Tut7 / 501515	RGDID:	1586015	Length:	1550	Species:	Rattus norvegicus

Alignment Length:	433	Identity:	85/433 - (19%)
Similarity:	156/433 - (36%)	Gaps:	139/433 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PGD---------------GDGNLVLCMVCAAPFRSMQDCLAHELIKHASKPQ--KQLR-QRLNAI 58
            |||               |....|:|.:|.......:||           |:  |::: :.|..:
  Rat   944 PGDQSEFFYEFRKLTFTKGKSPTVVCSLCKREGHLKKDC-----------PEDFKRIQLEPLPPL 997

  Fly    59 TKLFNSAQSQ----------------SERQELREALEWSESGGHLCTVLNFFACDLENMKTCFGH 107
            |..|::...|                ..|:.:|:.||            :|...|....|...
  Rat   998 TPKFSNILDQVCIQCYKDFSPTIVEDQAREHIRQNLE------------SFIKQDFPGTKLSL-- 1048

  Fly   108 VRNCIEKEMRGRVRVFPFGSLVTGLALKESDIDLFLEPNGNQPP--LFHNQLYNKTSHFLRRSKC 170
                             |||...|...|:||:|:.:..||::..  |...:...:.:..||:...
  Rat  1049 -----------------FGSSKNGFGFKQSDLDVCMTINGHETAEGLDCVRTIEELARVLRKHSG 1096

  Fly   171 FADVFTIRHASVPIIRCKHQLTGLNIDINMSNPNSIYNSRFVGELMFRNERIRELCLFLKIWAKK 235
            ..::..|..|.|||::..|..:||.:||::.|..:::|:|.:......:.|::.||..:|::.|.
  Rat  1097 LRNILPITTAKVPIVKFSHLRSGLEVDISLYNTLALHNTRLLFAYSAIDPRVKYLCYTMKVFTKM 1161

  Fly   236 LKL--ISHGGMTSYCLISLIIVNLQVNRLVPSVKELQSLC-----PPVILSGVNYAYSLDLTPPI 293
            ..:  .|.|.::||....:::..|| .|..|.:..||.:.     |.:::.|.| .|..|....:
  Rat  1162 CDIGDASRGSLSSYAYTLMVLYFLQ-QRSPPVIPVLQEIYKGEKKPEILVDGWN-IYFFDQINEL 1224

  Fly   294 PA-------RLTTLDLLKNFFIYYCTVNFD----------KSVLSPFLGGCVDKETTLGMPGGFP 341
            |.       ...::..|....:.:.|..||          ||:|:.|     .|:.|
  Rat  1225 PTCWPEYGKNTESVGQLWLGLLRFYTEEFDFKEHVISIRRKSLLTTF-----KKQWT-------- 1276

  Fly   342 EYDEQQKLVHDAIGAPPDAFQLDRAMCVQDPFELSRNVAKSVS 384
                                  .:.:.::|||:|:.|:...:|
  Rat  1277 ----------------------SKYIVIEDPFDLNHNLGAGLS 1297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mkg-p	NP_001286981.1	NT_PAP_TUTase	104..216	CDD:143392	26/113 (23%)
Tut7	XP_006253593.1	TUTase	205..539	CDD:408858
		PAP_assoc	550..599	CDD:397761
		TRF4	983..>1314	CDD:227585	76/383 (20%)
		NT_PAP_TUTase	1025..1142	CDD:143392	33/147 (22%)
		ZnF_C2HC	1347..1362	CDD:197667
		TUTF7_u4	1370..1451	CDD:406924
		ZnF_C2HC	1453..1469	CDD:197667
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	44	1.000	Domainoid score	I11979
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12271
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010