DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mkg-p and tut1

DIOPT Version :9

Sequence 1:	NP_001286981.1	Gene:	mkg-p / 38955	FlyBaseID:	FBgn0035889	Length:	659	Species:	Drosophila melanogaster
Sequence 2:	XP_002941502.3	Gene:	tut1 / 100127188	XenbaseID:	XB-GENE-491663	Length:	843	Species:	Xenopus tropicalis

Alignment Length:	753	Identity:	147/753 - (19%)
Similarity:	253/753 - (33%)	Gaps:	252/753 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 RSMQ----DCLAHELIKHASKPQKQLRQRLNAITKLFNSAQSQSERQELREALEWSESGGHLCTV 90
            |::|    :.|:.||:..|     .:.|::..:..|.:.:..:|..:||..:|...       |.
Frog   149 RTLQPPDPEALSKELLNCA-----DVEQQIKKLVSLCSPSHHESHLRELLLSLLQE-------TF 201

  Fly    91 LNFF-ACDLENMKTCFGHVRNCIEKEMRGRVRVFPFGSLVTGLALKESDIDLFLE---------- 144
            ..|| .|.|                        .||||.|.|..:...|:||:|:
Frog   202 TEFFPGCQL------------------------LPFGSSVNGFEISGCDLDLYLDLGDDEAENVE 242

  Fly   145 -----------------------------------------------PNGNQPPLFHNQLYNKTS 162
                                                           |..:...|...::.....
Frog   243 GKAEKEIQNREESSTDMEVSIEDPETERKEEEMEIGNSKNDEDEDVTPGLSLKGLSSEEILEVVG 307

  Fly   163 HFLRRSKCFADVFTIRH---ASVPIIRCKHQLTGLNIDINMSNPNSIYNSRFVGELMFRNERIRE 224
            ..||.  |...|..::.   |..|:|..:|:.:||..|:.::|..::.||.|:......:.|:.:
Frog   308 KVLRH--CVPGVHGVQSVPTARRPVIHFQHKTSGLRGDVTLNNRLALRNSSFLRLCSDLDARVPQ 370

  Fly   225 LCLFLKIWAKKLKLISH---GG--MTSYCLISLIIVNLQVNR--LVPSVKELQSLCP---PVILS 279
            |...::.||:..:|..:   ||  :.:|.|..|:...||...  ::|::..|:....   |.::.
Frog   371 LVYTVRYWARVNQLAGNPFGGGPLLNNYALTLLVFFFLQTRNPPVLPTLVHLREETANEVPQVID 435

  Fly   280 GVNYAYSLDLTPPIPARL-------TTLDLLKNFFIYYCTVNFDKSVLSPFLGGCVDKETTLGMP 337
            |.:.::     |..||::       :...||..||.:|.:::....:|.|..|      .|:.:|
Frog   436 GWDCSF-----PSDPAQVKESGNQQSLSSLLSEFFSFYASLDLHLLILCPCNG------LTIPLP 489

  Fly   338 GGFPEYDEQQKLVHDAIGAPP---DAFQLDRAMCVQDPFELSRNVAKSVSISNLCYFRQCLVLAA 399
            ...|               ||   :.|:|. .:.:|||||||.||..:||......|......||
Frog   490 FSSP---------------PPAWSEGFRLG-PLNIQDPFELSHNVCGNVSSRAARRFISHCAAAA 538

  Fly   400 QAC------------------------SDQELTSQ-------------PEKLY--------DYLL 419
            :.|                        :::|...:             |||.|        |.||
Frog   539 RICRTPNYNLHSTSHPWGITPILLPPPTERECVGRGGTEISIPLGGVSPEKTYAAVSKVFVDVLL 603

  Fly   420 FGLADKLVADKIVADKRSERAT--PRKQQKIENAHV-------QPPIVDETQETKVA-------- 467
            ..|.:.. .|.....|..|.:|  .:.|.|:|...|       :.|...|...||.|
Frog   604 CTLEEGR-EDSCQEGKALELSTKHAKAQCKVEKNEVGGELGEQEVPCKAEQNNTKEASKQKSIFK 667

  Fly   468 -EVGVCGTPPLVRSHVIT-PTTNDVKCLRSIVLVKNTENDQSIYYYWLICYVDTIKDVLTQLYAL 530
             |.|:  |....|...:| |..:|:...:.    :..|..:.|:.:.|            ...|:
Frog   668 TEEGM--TESARRKREMTEPCMSDMTNGKK----RRLEFTRGIWDHHL------------ATSAM 714

  Fly   531 NVEL-----KESKEPKHY------KWLISISYDTWTGRSFQRGAGQSFFAHQLQQTIEFTKT--- 581
            ..|:     |:||....|      :|.:.:.:..|.||..:|...|...|..::..|..::.
Frog   715 EEEMCGEAHKDSKTKIDYSNNGTAQWELLVWHRVWEGRRKERRRKQKGEADGVELEIAVSQALAL 779

  Fly   582 ----RMGNPQYAVNLRGYFTLQAS-EDYKELRLDVQPL 614
                :...|...:.|....|::.| :.|...:.|.|.|
Frog   780 EKEDKCDGPLMKLILTAQLTVKESLQLYLTPKFDPQGL 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mkg-p	NP_001286981.1	NT_PAP_TUTase	104..216	CDD:143392	27/171 (16%)
tut1	XP_002941502.3	RRM_TUT1	63..136	CDD:409721
		NT_PAP_TUTase	198..362	CDD:143392	32/196 (16%)
		TRF4	<320..>512	CDD:227585	47/218 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2580
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910