DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7120 and CG16854

DIOPT Version :9

Sequence 1:	NP_001246667.1	Gene:	CG7120 / 38954	FlyBaseID:	FBgn0035888	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	NP_001245974.1	Gene:	CG16854 / 34539	FlyBaseID:	FBgn0032338	Length:	705	Species:	Drosophila melanogaster

Alignment Length:	732	Identity:	207/732 - (28%)
Similarity:	337/732 - (46%)	Gaps:	81/732 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EKRLLLDPSTSESEEPEVHMTRRAGGVLHAIQHRPLPVSR---KSVLGLLVSFTFCYF------- 57
            |.:.||||.         .||:|  .:....::..:..:|   |.|  ::|.|..|.|
  Fly    19 ESKYLLDPK---------FMTKR--DLQQYYRYYNMNKNRGQFKKV--VIVIFALCVFSYLCVDY 70

  Fly    58 ------LIGRTGWVNVLDLDVLHSDNYVTVQHQSTVMDVEPEPITETNPSVPKGFLVYSNSCRIM 116
                  |..|.|:    |......|:|                    ..:|...:.|.:..||:.
  Fly    71 NLRTKLLRFRDGF----DFMARIEDHY--------------------GGNVTTAYFVDTTGCRMP 111

  Fly   117 EVDPYKNEVMRHFKRIKYKSCQKLTPLTQVKFEAKSQKYLLSIDGAAFGRYPVGKQLHCCYMSVQ 181
            ..:...:.:.:...:.:..||.:....|......:....|.:.:..|:........::|.|..|:
  Fly   112 HFEVSDDTIAQFIFKPRPYSCNRALIRTSDTIPGQLHLNLEASELLAYYNISDLSSVNCNYTEVK 176

  Fly   182 RVDEMKVKYTKCQTFK--GSILLPDSAEGIIVKC-DSGGRQIYINGHATVPVKEAVQQRLRMASE 243
            |..:....::...:||  ..:.||.|:|.|.:.| ||..:..|.:.|.....|..::..|:..::
  Fly   177 RKTDSSNTHSPAVSFKLDKVMKLPLSSEFICMWCYDSLDKLFYKDCHFFAVDKPRIRPPLKTGTD 241

  Fly   244 A----DAKGYQRPPSVLMLGIDSISRVNLIRAMPKTAQYLYDN-GWFELAGYNKVDDNTFPNIMA 303
            .    .:|..|...||::||:||:|.:|.:|.|.:||.|:..: ...|..|||||.||||||::.
  Fly   242 RVSFNKSKEEQERLSVMILGMDSLSHLNFLRQMRRTANYVRKHLSHVEFWGYNKVGDNTFPNLVP 306

  Fly   304 VLTGYNLPNAMHACSPFVVGGLDKCDYIWKQYQQRGYVTAYAEDAVKINTFNYLKKGFKNPPADY 368
            :|:|.:......||:|..:...|:|.:|||:|||.||.:.:|||...::.|||.:.||:..|.||
  Fly   307 LLSGLDDQELNLACTPKTLRSYDRCSFIWKRYQQLGYRSIFAEDVAMLSAFNYNQNGFRKQPTDY 371

  Fly   369 YLRPYLSAAESQLDHTTVNGLVHCLGYLTAAEHVYDYGLEFTRRFLNETYFGFFWTNTHSHSDIS 433
            ||||.:...|..:.......:..|:|....|:.:.:|..:...|...:.||.||||...:|...:
  Fly   372 YLRPMIMEMEKTVAFKKDLNMHLCMGSRRTADVLLEYMKKLVPRMSRDLYFSFFWTVALTHDYFN 436

  Fly   434 QTSSMDSYMEEYLRKLVRQGTMENTVVVFFSDHGMRFGPTRATWSGHLEERLPAIFIWLPQHLRR 498
            ..|.:|..|.:.|.:|...|.:..|||:..||||:|:|..|.|:.|.:|||.|.:.:..|..:..
  Fly   437 FPSLLDEAMLQQLMQLQDSGLLNRTVVMLLSDHGLRWGSFRRTYQGMMEERQPLMMLLYPPWMTE 501

  Fly   499 SHPQFVRSLQLNRNRLTTPYDLHLTMKHILAISG-------RAEMESLGPAPDCPQCQSLLTPVS 556
            .:|:.:.:|:||..|||||:|:|.||..:|.:..       |...|...|....|:..||..|:.
  Fly   502 RYPEAIANLRLNARRLTTPFDVHATMLQLLNLHNLEADQLQRRSTEMDEPDSTLPRGISLFLPIP 566

  Fly   557 PQRSCSDVGIADHWCTCWEYDTISSTSKESRMLGKRVVSYLNNYVAEFRNGTFAKLCAPLSLHSI 621
            ..|:|...|||.|||||.:...:.:.....:...:.:|..:||.:.:      :..|..|.|:||
  Fly   567 AARTCEQAGIAAHWCTCHQRQELQTNDPRVQRAARYLVRLINNRLKD------SSQCRTLYLNSI 625

  Fly   622 KSA-FRAHHNA----LDPDEVHTYRLIFVTSPNKGQYEATLRHNHTDDSVKVTGSVSRLNVYSGE 681
            ..| ..|.|:.    :..|......|...|.|..|.:|:|:|  .|..:..:||::||||:|..:
  Fly   626 LQALIAAPHSKIVKNISTDYAVDITLRLQTKPGLGVFESTVR--MTGYTTVLTGTISRLNLYGSQ 688

  Fly   682 ADCMNDFAAKKYCYCRK 698
            :.|:||.|.|.:|||.:
  Fly   689 SYCLNDPALKMFCYCHR 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7120	NP_001246667.1	DUF229	130..622	CDD:281053	154/506 (30%)
CG7120	NP_001246667.1	ALP_like	253..528	CDD:293745	104/275 (38%)
CG16854	NP_001245974.1	DUF229	126..626	CDD:281053	154/505 (30%)
CG16854	NP_001245974.1	ALP_like	255..533	CDD:293745	105/277 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466471
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JJT
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D31599at6960
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm4742
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850