DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7120 and CG31933

DIOPT Version :9

Sequence 1:	NP_001246667.1	Gene:	CG7120 / 38954	FlyBaseID:	FBgn0035888	Length:	701	Species:	Drosophila melanogaster
Sequence 2:	NP_722734.1	Gene:	CG31933 / 326176	FlyBaseID:	FBgn0051933	Length:	673	Species:	Drosophila melanogaster

Alignment Length:	743	Identity:	178/743 - (23%)
Similarity:	302/743 - (40%)	Gaps:	166/743 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 RKSVLGLLVSFTFCYFLIGRTGWVNVLDLDVLHSDNYVTVQHQSTVMDVEPEPITETNPSVPKGF 106
            ||.|||::::....|.|:            .|.:..|                  ||...:...|
  Fly     7 RKLVLGVILTTIILYALL------------FLDTQCY------------------ETGGKIHNAF 41

  Fly   107 LVYSNSCRIMEVDPYKNEVMRHFKRIKYKSCQKLTPLTQVKFEAKSQKYLLSIDGAAFGRYPVGK 171
            .|.::.|||:.:|.....:.::                 ..:|.|.:::.|......:.|..|..
  Fly    42 FVNTDGCRIIAMDVMNPTIAKY-----------------TDWEWKDKRFYLKCPHQTWFRTEVAN 89

  Fly   172 ------------------------QLHCCYMSVQRVDEMKVKYTKCQTF----KGSILLPDSAEG 208
                                    |:.|.:..::.....:.|......|    ..::.:|.....
  Fly    90 GDWYLKLTRDIDRILQESDLTHDWQIKCYWFRIKIKGRWRAKIYGPTMFPLEYPYALKVPKGLRH 154

  Fly   209 IIVKC--DSGGRQIYINGHATV-PVKEAVQQRLRMA-----SEADAKGYQRPPSVLMLGIDSISR 265
            :.|||  ....:.::.:.|..: |..|.:.::....     .|..:.|...|.||::||:||:|.
  Fly   155 MRVKCLNTFTNKTLHDDAHFFIQPPPEKLLKKPPATLKYWDGEKHSSGATSPISVMILGLDSVSH 219

  Fly   266 VNLIRAMPKTAQYLYDN-GWFELAGYNKVDDNTFPNIMAVLTGYNLPNA-----MHACSPFVVGG 324
            :||:|.||:|.:|:..| ...|..|:||:..||:||::|:|||.:...:     ...|
  Fly   220 LNLLRQMPRTVRYMRQNMSQVEFWGFNKIGTNTYPNLIALLTGLSAAESEAYWVRQKC------- 277

  Fly   325 LDKCDYIWKQYQQRGYVTAYAEDAVKINTFNYLKKGFKNPPADYYLRP-----YLSAAESQLDHT 384
            :|....|||::::.||.|::|||....:.|.:.|.|||.|..|..|..     |::...|.:..|
  Fly   278 MDNLPLIWKEFKRAGYNTSFAEDMAIYSMFYFGKPGFKRPTTDNNLHDFMVDLYINRQASSVSDT 342

  Fly   385 TVNGLVHCLGYLTAAEHVY-DYGLEFTRRFLNET----YFGFFWTNTHSHSDISQTSSMDSYMEE 444
                  ||:|     |..: |..||...|.|..|    :|.|:|.....|...:.....|...|.
  Fly   343 ------HCMG-----ERAFMDILLEMNDRLLPHTQRYPFFSFYWWANGFHEFFNSPRLADGRFER 396

  Fly   445 YLRKLVRQGTMENTVVVFFSDHGMRFGPTRATWSGHLEERLPAIFIWLPQHLRRSHPQFVRSLQL 509
            .||.|...|...||::.|.||||:|:|..|:::.|.:|:..|.:.:..|:.:|..:|..::||..
  Fly   397 LLRSLDDAGITNNTIIFFMSDHGLRWGLFRSSFQGMIEDSQPFLSVLYPKWMRLKYPMAIKSLVG 461

  Fly   510 NRNRLTTPYDLHLTMKHIL--------AISGRAEMESLGPAPDCPQCQSLLTPVSPQRSCSDVGI 566
            |.:.|.|.||||.|:||||        :|:.:.|..........|:..||..|:.|.|:|:...|
  Fly   462 NAHSLVTTYDLHETLKHILEPSSLEDTSITQKTEELWKLKGSQTPRAVSLFLPIPPWRNCNTSHI 526

  Fly   567 ADHWCTCWEYDTISSTSKESRMLGKRVVSYLNNYVAEFRNGTFAKLCAPLSLHSIKSAF------ 625
            ...:|.|.:...|..:::........::.|:|..:.|:      .:|.||.|.||:||:
  Fly   527 PSKFCLCHKQIPIPESNRVVTKSASIIIDYVNQLMVEY------PVCIPLQLDSIESAYFAAPQR 585

  Fly   626 -------RAHHNALDPD-------EVHTYRLIFV---TSPNKGQYEATLRHNHT-----DDSVKV 668
                   :.|.|.. |:       :.:..|.|.|   |.|....:|...|...:     .:.|:|
  Fly   586 DDDFYIEKGHKNVY-PEKGPFWKKQKYEDRDIVVRLKTKPGNAYFEGMTRRQGSKLSLVGEVVRV 649

  Fly   669 TGSVSRLNVYSGEADCMNDFAAKKYCYC 696
            .|..:|.|      ||:::...:.:|:|
  Fly   650 GGEGNRNN------DCIDNPLLEPFCHC 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7120	NP_001246667.1	DUF229	130..622	CDD:281053	139/551 (25%)
CG7120	NP_001246667.1	ALP_like	253..528	CDD:293745	97/290 (33%)
CG31933	NP_722734.1	DUF229	114..576	CDD:281053	134/485 (28%)
CG31933	NP_722734.1	ALP_like	208..483	CDD:293745	99/292 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466469
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28JJT
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D31599at6960
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850