DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jon66Cii and TMPRSS2

DIOPT Version :9

Sequence 1:	NP_648217.1	Gene:	Jon66Cii / 38953	FlyBaseID:	FBgn0035887	Length:	262	Species:	Drosophila melanogaster
Sequence 2:	NP_001128571.1	Gene:	TMPRSS2 / 7113	HGNCID:	11876	Length:	529	Species:	Homo sapiens

Alignment Length:	242	Identity:	71/242 - (29%)
Similarity:	104/242 - (42%)	Gaps:	35/242 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 QGRITNGYPAEEGKAPYTVGLGFSGGWWCGGSIIAHDWVLTAEHCI--------------GDADS 87
            |.||..|..|..|..|:.|.|.......||||||..:|::||.||:              |....
Human   290 QSRIVGGESALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQ 354

  Fly    88 VTVYFGATWRTNAQFTHWVGNGNF-IKHSSADIALIRIPH-VDFWHMVNKVELPSYNDRYNDYNE 150
            ..:::||.::.....:|    .|: .|..:.||||:::.. :.|..:|..|.||:..........
Human   355 SFMFYGAGYQVEKVISH----PNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQL 415

  Fly   151 WWAVACGWGGTYDGSPLPDYLQCVDLQIIHNSECSGYYGSVGDNI-----LCVRTPDGK-STCGG 209
            .|  ..|||.|.:.....:.|....:.:|....|:..|  |.||:     :|.....|. .:|.|
Human   416 CW--ISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRY--VYDNLITPAMICAGFLQGNVDSCQG 476

  Fly   210 DSGGPLVTHDGT--KLVGVTNFGSVAGC-QSGAPAGFQRVTYHLDWI 253
            ||||||||....  .|:|.|::||  || ::..|..:..|....|||
Human   477 DSGGPLVTSKNNIWWLIGDTSWGS--GCAKAYRPGVYGNVMVFTDWI 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jon66Cii	NP_648217.1	Tryp_SPc	39..253	CDD:214473	68/238 (29%)
Jon66Cii	NP_648217.1	Tryp_SPc	40..256	CDD:238113	69/239 (29%)
TMPRSS2	NP_001128571.1	DUF3824	<44..91	CDD:289625
		LDLa	150..185	CDD:238060
		SRCR_2	190..283	CDD:292133
		Tryp_SPc	292..521	CDD:214473	68/238 (29%)
		Tryp_SPc	293..524	CDD:238113	69/239 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910