DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jon66Cii and MASP1

DIOPT Version :9

Sequence 1:	NP_648217.1	Gene:	Jon66Cii / 38953	FlyBaseID:	FBgn0035887	Length:	262	Species:	Drosophila melanogaster
Sequence 2:	XP_011511291.1	Gene:	MASP1 / 5648	HGNCID:	6901	Length:	735	Species:	Homo sapiens

Alignment Length:	303	Identity:	77/303 - (25%)
Similarity:	122/303 - (40%)	Gaps:	71/303 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GATMPRLATEKLTPVHT-KDMQGRITNGYPAEEGKAPYTVGLGF-------SGGWWCGGSIIAHD 73
            |.::|....|...|..: ..:..||..|..||.|..|:...:..       :..|:..|::::..
Human   433 GRSLPTCLPECGQPSRSLPSLVKRIIGGRNAEPGLFPWQALIVVEDTSRVPNDKWFGSGALLSAS 497

  Fly    74 WVLTAEHCIG-----------DADSVTVYFG------ATWRTNAQFTHWVGNGNF-IKHSSADIA 120
            |:|||.|.:.           ..:.||||.|      .:...|:.....|.:.:| |::.:.|||
Human   498 WILTAAHVLRSQRRDTTVIPVSKEHVTVYLGLHDVRDKSGAVNSSAARVVLHPDFNIQNYNHDIA 562

  Fly   121 LIRI-------PHVDFWHMVNKVELPSYNDRYNDYNEWWAVACGWG--------------GTYDG 164
            |:::       ||      |..|.||..... ........:..|||              ||
Human   563 LVQLQEPVPLGPH------VMPVCLPRLEPE-GPAPHMLGLVAGWGISNPNVTVDEIISSGT--- 617

  Fly   165 SPLPDYLQCVDLQIIHNSEC-------SGYYGSVGDNILCVRTPD-GKSTCGGDSGGPLVTHDGT 221
            ..|.|.||.|.|.::.::||       ||.| ||.:|:.|....: ||.||.|||||..|..|..
Human   618 RTLSDVLQYVKLPVVPHAECKTSYESRSGNY-SVTENMFCAGYYEGGKDTCLGDSGGAFVIFDDL 681

  Fly   222 K----LVGVTNFGSVAGCQSGAPAG-FQRVTYHLDWIRDHTGI 259
            .    :.|:.::|....|.|....| :.:|:.::||:.:..|:
Human   682 SQRWVVQGLVSWGGPEECGSKQVYGVYTKVSNYVDWVWEQMGL 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jon66Cii	NP_648217.1	Tryp_SPc	39..253	CDD:214473	71/272 (26%)
Jon66Cii	NP_648217.1	Tryp_SPc	40..256	CDD:238113	71/274 (26%)
MASP1	XP_011511291.1	CUB	35..144	CDD:238001
		FXa_inhibition	160..188	CDD:291342
		CUB	192..301	CDD:278839
		Sushi	308..369	CDD:278512
		CCP	374..439	CDD:153056	2/5 (40%)
		Tryp_SPc	456..718	CDD:214473	71/272 (26%)
		Tryp_SPc	457..718	CDD:238113	70/271 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910