DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jon66Cii and LPA

DIOPT Version :9

Sequence 1:	NP_648217.1	Gene:	Jon66Cii / 38953	FlyBaseID:	FBgn0035887	Length:	262	Species:	Drosophila melanogaster
Sequence 2:	NP_005568.2	Gene:	LPA / 4018	HGNCID:	6667	Length:	2040	Species:	Homo sapiens

Alignment Length:	245	Identity:	80/245 - (32%)
Similarity:	113/245 - (46%)	Gaps:	44/245 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VHTKDMQGRITNGYPAEEGKAPYTVGLGFS-GGWWCGGSIIAHDWVLTAEHCIGDA---DSVTVY 91
            |..|...|.|..|..|.....|:.|.|... |..:|||::|:.:|||||.||:..:   .|..|.
Human  1811 VEPKKCPGSIVGGCVAHPHSWPWQVSLRTRFGKHFCGGTLISPEWVLTAAHCLKKSSRPSSYKVI 1875

  Fly    92 FGATWRTNAQFTHWVG---NGNFIKHSSADIALIRI--PHVDFWHMVNKVE---LPSYNDRYNDY 148
            .||....|.: :|...   :..|::.:.|||||:::  |.|    :.:||.   |||     .||
Human  1876 LGAHQEVNLE-SHVQEIEVSRLFLEPTQADIALLKLSRPAV----ITDKVMPACLPS-----PDY 1930

  Fly   149 NEWWAVAC---GWG---GTYDGSPLPDYLQCVDLQIIHNSECSGYYGSVGDNILCV-RTPDGKST 206
            .......|   |||   ||: |:.|   |:...|.:|.|..|:.|      ..:|. ....|..:
Human  1931 MVTARTECYITGWGETQGTF-GTGL---LKEAQLLVIENEVCNHY------KYICAEHLARGTDS 1985

  Fly   207 CGGDSGGPLVTHDGTK--LVGVTNFGSVAGC-QSGAPAGFQRVTYHLDWI 253
            |.||||||||..:..|  |.|||::|  .|| :...|..:.||:..:.||
Human  1986 CQGDSGGPLVCFEKDKYILQGVTSWG--LGCARPNKPGVYARVSRFVTWI 2033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jon66Cii	NP_648217.1	Tryp_SPc	39..253	CDD:214473	75/235 (32%)
Jon66Cii	NP_648217.1	Tryp_SPc	40..256	CDD:238113	77/236 (33%)
LPA	NP_005568.2	Kringle	28..105	CDD:278480
		Kringle	142..219	CDD:278480
		Kringle	256..333	CDD:278480
		Kringle	370..447	CDD:278480
		Kringle	484..561	CDD:278480
		Kringle	598..675	CDD:278480
		Kringle	712..789	CDD:278480
		Kringle	826..903	CDD:278480
		KR	938..1019	CDD:214527
		Kringle	1054..1131	CDD:278480
		KR	1166..1246	CDD:214527
		KR	1272..1352	CDD:214527
		KR	1386..1466	CDD:214527
		KR	1500..1581	CDD:214527
		KR	1614..1695	CDD:214527
		Kringle	1720..1799	CDD:278480
		Tryp_SPc	1820..2034	CDD:238113	77/236 (33%)
		Tryp_SPc	1820..2033	CDD:214473	75/234 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910