DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Jon66Cii and F2

DIOPT Version :9

Sequence 1:	NP_648217.1	Gene:	Jon66Cii / 38953	FlyBaseID:	FBgn0035887	Length:	262	Species:	Drosophila melanogaster
Sequence 2:	NP_000497.1	Gene:	F2 / 2147	HGNCID:	3535	Length:	622	Species:	Homo sapiens

Alignment Length:	270	Identity:	72/270 - (26%)
Similarity:	105/270 - (38%)	Gaps:	66/270 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 MQGRITNGYPAEEGKAPYTVGLGFSGG---WWCGGSIIAHDWVLTAEHCI--------GDADSVT 89
            :.|||..|..||.|.:|:.|.| |...   ..||.|:|:..|||||.||:        ...:.:.
Human   360 IDGRIVEGSDAEIGMSPWQVML-FRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLL 423

  Fly    90 VYFGATWRTNAQ------------FTHWVGNGNFIKHSSADIALIRIPH-VDFWHMVNKVELP-- 139
            |..|...||..:            :.|  ...|:.::...||||:::.. |.|...::.|.||
Human   424 VRIGKHSRTRYERNIEKISMLEKIYIH--PRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDR 486

  Fly   140 ---------SYNDRYNDYNEWWAVACGWGGTYD------GSPLPDYLQCVDLQIIHNSECSGYYG 189
                     .|..|          ..|||...:      |...|..||.|:|.|:....|.....
Human   487 ETAASLLQAGYKGR----------VTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTR 541

  Fly   190 -SVGDNILCV--RTPDGK--STCGGDSGGPLVT----HDGTKLVGVTNFGSVAGCQSGAPAGFQR 245
             .:.||:.|.  :..:||  ..|.||||||.|.    ::....:|:.::|.  ||......||..
Human   542 IRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGE--GCDRDGKYGFYT 604

  Fly   246 VTYHL-DWIR 254
            ..:.| .||:
Human   605 HVFRLKKWIQ 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Jon66Cii	NP_648217.1	Tryp_SPc	39..253	CDD:214473	69/264 (26%)
Jon66Cii	NP_648217.1	Tryp_SPc	40..256	CDD:238113	70/266 (26%)
F2	NP_000497.1	GLA	25..88	CDD:214503
		KR	105..186	CDD:238056
		KR	211..293	CDD:214527
		Thrombin_light	317..363	CDD:286482	0/2 (0%)
		Tryp_SPc	363..613	CDD:214473	69/264 (26%)
		Tryp_SPc	364..616	CDD:238113	70/266 (26%)
		High affinity receptor-binding region which is also known as the TP508 peptide	551..573		9/21 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910