Protein Alignment KTN1 and alt

DIOPT Version :10

• Sequence 1: NP_001072989.1
• Gene: KTN1 / 3895
• HGNCID: 6467
• Length: 1357
• Species: Homo sapiens
• Sequence 2: NP_650645.1
• Gene: alt / 42127
• FlyBaseID: FBgn0038535
• Length: 874
• Species: Drosophila melanogaster
• Alignment Length: 1303
• Identity: 254/1303 - (19%)
• Similarity: 470/1303 - (36%)
• Gaps: 477/1303 - (36%)

Human     1 MEFYESAYFIVLIPSIVIT---VIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKK--AEKK 60
            |:|:     |:::...|::   :.|||.....:...::||:|    |::.:.....|..  |..|
  Fly     1 MDFH-----ILIVIGCVVSASLLSFLFINKIFRRKTFEEVVA----EKRALSANLYKAAGGAATK 56

Human    61 KNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVL 125
            |.||||::             |:.|........|....|.|....:.|....|.:.....::|.|
  Fly    57 KPKKKELK-------------REKKQRQREQQRDVNNEPEPEEAEDYSDGQSEGQGSVAGEEPGL 108

Human   126 EEQVIK-ESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSK 189
            .:|.:: |.||..:..:: .|..|.::...||.|.    |.|:|..:||:::   |...::|
  Fly   109 SKQHVEFEPDAEVLTDQR-RPSSVAEKENQPSGAG----KKGKKDKRNGANN---KTAGILV--- 162

Human   190 RQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDL 254
                      .|.|:.:.|..|::::..|.|.|        .|.||             ::|::|
  Fly   163 ----------NKNETVAVKPAANAEETPTLNNF--------ETKIP-------------KDVVEL 196

Human   255 LKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDAL 319
            .|.:|.|                                              .||.:...|.:.
  Fly   197 KKQEQKE----------------------------------------------RKEDNNNKQQSQ 215

Human   320 KKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLE 384
            ||.:.|.::       :|:|::|...|....||...||       ::::.|          |:.:
  Fly   216 KKIAGGNVS-------KKEKVVAVETEAPVVTKQILKQ-------QQQQQN----------GSPK 256

Human   385 KEHNVFQNKIHVSYQETQQMQMKFQQVREQMEA-EIAHLKQENGILRDAVSNTTNQLESKQSAEL 448
            .:||...||      ..||.|.|.|..:|.:.. ::||       ..|.:::..|     |:..:
  Fly   257 TQHNQANNK------TKQQQQNKKQNQKETLTGKDLAH-------ALDKLADHQN-----QTIGV 303

Human   449 NKLRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEA 513
            |.|...::|                                   ||....|:|..|
  Fly   304 NALMNVFSR-----------------------------------AELNRSEIQILI--------- 324

Human   514 AQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQN 578
                  ...:.|:.::.:.||:.:|.:.      |:|.:.:|.::|.:.:|:...:.:|..|.:
  Fly   325 ------DYLLNKQQDMPASHSEWSDDIC------QKLKRQLEEKEKLLAEEQEASIGIQAKLRE- 376

Human   579 EALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEEL----KD 639
              |:.::....:|:.|:..|.:                           |:|..||:||    ::
  Fly   377 --LRQEVNTERAQMHARNQAYI---------------------------DKLQGKEQELAALNQE 412

Human   640 IQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILN 704
            :.::|..|..|.|:|..|..|:.|.:.:|.::|               .||.::::|.   |.|.
  Fly   413 LSSLNDKLTLERQQLTTLRREKQANSQDLVQLQ---------------HLQQDLAHKE---KCLA 459

Human   705 DQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIR 769
            :....:.:|.|                |..:.||::.::|:.:|
  Fly   460 EMTAFVNAETQ----------------QKNEVIQQQAQQLQALE--------------------- 487

Human   770 TENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDL 834
                 |.:|  :|:|:||:                       |:.||.:.:.|:..|     .||
  Fly   488 -----LQRE--ELEARQNN-----------------------SIFELEQRKQLEAEN-----ADL 517

Human   835 KQEIKALKEEIGNVQLEKAQQLSITSKVQEL-QNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQ 898
            |||:.|:::....:|...|.:|      ||| |||            :|||.:...|:.     |
  Fly   518 KQELSAVQQTQSELQRVHAAEL------QELRQNL------------SVLEARNVALSQ-----Q 559

Human   899 DLQEENESLKAHVQEVAQHNLKEASSASQFEELEI---VLKEKENELKRLEAMLKERESDLSSKT 960
            ..|..|.:::|              :|:|.|:.::   .|.:|:.||..|       .|.:.|.|
  Fly   560 LTQAANSAVQA--------------TAAQSEQAQVQTEALAQKQQELSAL-------RSQVGSLT 603

Human   961 QLLQDVQDENKLFKSQIEQLKQQNYQQASSFPPHEELLKVISEREKEISGLWNELDSLKDAVEHQ 1025
            ......|.:....:||::: .||..:|..:...|                       |:..::.|
  Fly   604 DAHAQQQKQANALQSQLQE-AQQRAEQLQAKEQH-----------------------LQQELQEQ 644

Human  1026 RKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQVEAVELEAKEVLKKLFPKVSVPSNLS 1090
            |:||||:|.|||:.:|||.:.|.:       |:|.:....::|..:.||:  :|..:.:|.:|
  Fly   645 REKNNDVRMKNWKLIEALQNAEAL-------TAKTKTNSAQSVGQQHKEL--QLQQQKAVAAN-- 698

Human  1091 YGEWLHGFEKKAKECMAGTSGSEEVKVLEHKLKEADEMHTLLQLECEKYKS----VLAETEGILQ 1151
                             |...:...|..:.:::   :::..|..:..|.:|    ..:..:.:.|
  Fly   699 -----------------GGGSASSAKSEQQRIR---DLYQRLYPDAVKAQSGNALQASFDQWLEQ 743

Human  1152 KLQRSVEQEENKWKVKVD---------ESHKTIKQMQSSFTSSEQELERLRSENKDIENLRRERE 1207
            .|...|:|:::|.:.|:|         .|||:.:...|| :|:........|.|....|.:....
  Fly   744 VLATHVKQQQDKLRQKLDAEKSEKQSSSSHKSTQSSNSS-SSNHNSTHNNISSNNSSSNSQSSSA 807

Human  1208 HLEMELEKAEMERSTYVTEVRELKDLLTELQKKL--------------DDSYSEAVRQNEELNLL 1258
            ..:.||.|..:       ::||..|.||:|..|.              |:.:...|.|.|:|.|.
  Fly   808 AEQQELHKQNL-------QLRECNDKLTQLVTKTTNTLMDLEERAREQDEHWRGIVEQKEQLILT 865

Human  1259 KAQ 1261
            ..|
  Fly   866 LQQ 868

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KTN1	NP_001072989.1	Rib_recp_KP_reg	29..160	CDD:461548	30/133 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	48..81		8/34 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	103..218		24/115 (21%)
		EnvC	316..>532	CDD:443969	38/216 (18%)
		SMC_prok_B	448..1270	CDD:274008	164/849 (19%)
		Smc	<1190..>1357	CDD:440809	20/86 (23%)
alt	NP_650645.1	Smc	<370..>633	CDD:440809	85/427 (20%)
		Smc	<530..>822	CDD:440809	82/398 (21%)