DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Culd and DGCR2

DIOPT Version :9

Sequence 1:	NP_729364.1	Gene:	Culd / 38946	FlyBaseID:	FBgn0035880	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_005128.1	Gene:	DGCR2 / 9993	HGNCID:	2845	Length:	550	Species:	Homo sapiens

Alignment Length:	202	Identity:	45/202 - (22%)
Similarity:	67/202 - (33%)	Gaps:	61/202 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   437 NCYIGSEFLCGNNH-CISIRLHC--DGFDHCGDGSD----------EPDSCEEDWAHLHHDRRWY 488
            :||..|.|||..:. |:.|:.:.  :||.....|.|          ||:.|...........:.|
Human   256 SCYEKSSFLCKRSQTCVDIKDNVVDEGFYFTPKGDDPCLSCTCHGGEPEMCVAALCERPQGCQQY 320

  Fly   489 SHKPN--YYFPKIDQYPDLKT-----ATGI-FIISTLGIFGVLSGWMVILYRMGVRAR------- 538
            ...|.  ..|..:|  ||..:     |:|: .::|.:..|.:||..:.:::|:..|.|
Human   321 RKDPKECCKFMCLD--PDGNSLFDSMASGMRLVVSCISSFLILSLLLFMVHRLRQRRRERIESLI 383

  Fly   539 ----HQRELQSHLQTISELLDRQDEDRTP---------------DEPPSYEA------------P 572
                |...|...:.......|......||               |.||.|.|            |
Human   384 GANLHHFNLGRRIPGFDYGPDGFGTGLTPLHLSDDGEGGTFHFHDPPPPYTAYKYPDIGQPDDPP 448

  Fly   573 PDYEEVI 579
            |.||..|
Human   449 PPYEASI 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Culd	NP_729364.1	CUB	200..298	CDD:238001
Culd	NP_729364.1	LDLa	442..472	CDD:238060	11/42 (26%)
DGCR2	NP_005128.1	LDLa	30..66	CDD:238060
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..92
		CLECT_DGCR2_like	115..267	CDD:153069	6/10 (60%)
		VWC	271..329	CDD:214564	11/57 (19%)
		Atrophin-1	<428..537	CDD:331285	10/28 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..550
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900