Protein Alignment Culd and Lrp3

DIOPT Version :10

• Sequence 1: NP_729364.1
• Gene: Culd / 38946
• FlyBaseID: FBgn0035880
• Length: 965
• Species: Drosophila melanogaster
• Sequence 2: XP_038948896.1
• Gene: Lrp3 / 89787
• RGDID: 619729
• Length: 810
• Species: Rattus norvegicus
• Alignment Length: 679
• Identity: 135/679 - (19%)
• Similarity: 197/679 - (29%)
• Gaps: 238/679 - (35%)

  Fly    13 AYVICLLCWPGEAY-PASSSYRD-LDICNHWD----GRRHFLELGSPAGEVHARNVTTTAYRSSP 71
            |:.:|     |.|. ||..|.|| :.|..|.|    |:.....|....|::...:..|..:|..
  Rat   116 AFRLC-----GSAIPPAFISARDHVWIFFHSDASSSGQAQGFRLSYIRGKLGQASCQTDEFRCD- 174

  Fly    72 LVFKNDAVAGDVWYQCSLELVTCAECVIRVAFTYANFSKSCGNTGGKSSMCPCEHIQFSEPPYDS 136
                |.......| ||                   |....||: |.....|..   ..||||...
  Rat   175 ----NGKCLPGPW-QC-------------------NMVDECGD-GSDEGNCSA---PASEPPGSL 211

  Fly   137 TISGQEFCGDGKVFRSKTRTLQLKFFYRASNAHVFSLQYFSERNVRIVSGSPKQSIVGNGSTKSQ 201
            ...|...|...:    .||.|.::                     |...|:..   .|:||.::.
  Rat   212 CPGGTFPCSGAR----STRCLPVE---------------------RRCDGTQD---CGDGSDEAG 248

  Fly   202 -PQV-----ISTPYFPMAYPRDYGIE------HI--LTCEADNCQVRLDFTDFQLGLTSTLEIFD 252
             |.:     :.:.|...|.|..:|..      |.  |....|..:|.|.. :.:||....:::::
  Rat   249 CPDLACGRRLGSFYGSFASPDLFGAARGPSDLHCTWLVDTQDPRRVLLQL-ELRLGYDDYVQVYE 312

  Fly   253 SNGQMLD------SYTGEHFRPPITVSSGK-SLLLQFRGNSATGVGFRAEVSFVSSKQLKDERLV 310
            ..|:..|      ||...|....:..:.|: ::....|..|| |.||.|      :.|:|...|.
  Rat   313 GLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARSA-GHGFNA------TYQVKGYCLP 370

  Fly   311 PYTDCGGMVTGPGGAITMMNMIENATDVRLFDCIWIIKPGNNYMMMKTHISLRVDDFYGMAARSE 375
            ....||....|..|:
  Rat   371 WEQPCGSSSEGDDGS-------------------------------------------------- 385

  Fly   376 LTIRQGTTSDAVEIENVMWPNNGLSKESHVAPILNGYYIRLRGVFGMSSKLAIVYSVFNYLNCYI 440
             |..||..|:....:.  |.:....::....|..........|..|:.  .|......|..:|..
  Rat   386 -TGEQGCFSEPQRCDG--WWHCASGRDEQGCPACPPDQYPCEGGSGLC--YAPADRCNNQKSCPD 445

  Fly   441 GSE-----------FLCGNNHCISIRLHCDGFDHCGDGSDEPDSCEEDWAHLHHDRRWYSHKPNY 494
            |::           |.||.|.||.....|||.:.|.|||||                   |....
  Rat   446 GADEKNCFSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDE-------------------HGCLA 491

  Fly   495 YFPKIDQYPDLKTAT---------GIFIISTLGIFGVLSGWMVILYRMGVRA-------RHQREL 543
            ..|:       |..|         |:.::..||....|.......||...|.       |...|.
  Rat   492 AVPR-------KVITAALIGSLVCGLLLVIALGCAFKLYSLRTQEYRWAPRGGLAPRFFRFPGEN 549

  Fly   544 QSHLQTISELLDRQDE------------DRTPDEPPSYEAPPDYEEVIKVGM------------- 583
            ::..|.:..::..|::            .|...|....||||.|.::|..|:
  Rat   550 RTTFQAMGWVIPIQEDCFFVCMAFETQMTRLEAEFVRREAPPSYGQLIAQGLIPPVEDFPVYSAS 614

  Fly   584 ----QQELREP-RRQRR---ARRAPPRDR 604
                .|.||.. |||.|   :||.|.|.|
  Rat   615 QASVLQNLRTAMRRQMRRHASRRGPSRRR 643

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Culd	NP_729364.1	CUB	200..298	CDD:238001	25/118 (21%)
		LDLa	442..472	CDD:238060	15/40 (38%)
Lrp3	XP_038948896.1	CUB	43..156	CDD:238001	14/44 (32%)
		LDLa	166..200	CDD:238060	10/59 (17%)
		LDLa	212..249	CDD:238060	10/64 (16%)
		CUB	254..364	CDD:238001	24/117 (21%)
		LDLa	416..452	CDD:238060	6/37 (16%)
		LDLa	455..489	CDD:238060	16/52 (31%)