DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Culd and NETO2

DIOPT Version :9

Sequence 1:	NP_729364.1	Gene:	Culd / 38946	FlyBaseID:	FBgn0035880	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_060562.3	Gene:	NETO2 / 81831	HGNCID:	14644	Length:	525	Species:	Homo sapiens

Alignment Length:	658	Identity:	132/658 - (20%)
Similarity:	224/658 - (34%)	Gaps:	228/658 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 QLKFFYRASNAHVFSLQYF------SERNVRIVSGSPKQSIVGNGSTKSQPQVISTPYFPMAYPR 216
            |...:.|.||...|:...:      ::..:.|:..:|:|.|                  .:.:..
Human    44 QCGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAAPRQRI------------------ELTFDE 90

  Fly   217 DYGIEHILTCEADNCQVRLDFTDFQLGLTSTLEIFDSNGQMLDSYTGEHFRPPITVSSGKSLLLQ 281
            .|.||....|..|:.:||    |...|.:          .::|.|.|.. .||:..|:|:.:.::
Human    91 HYYIEPSFECRFDHLEVR----DGPFGFS----------PLIDRYCGVK-SPPLIRSTGRFMWIK 140

  Fly   282 FRGN-SATGVGFRAEVSFVSSKQLK--DERLVPYTDCGGMVTGPGGAI--TMMNMIENATDVRLF 341
            |..: ...|:||||:.||:......  ...|.|..||...::|..|.:  :.:...|.....:..
Human   141 FSSDEELEGLGFRAKYSFIPDPDFTYLGGILNPIPDCQFELSGADGIVRSSQVEQEEKTKPGQAV 205

  Fly   342 DCIWIIKPGNNYMMMKTHISLRVDDFY----GMAARSELTIRQGTTSDAVEIENVMWPNNGLSKE 402
            ||||.||     ...|..|.||..|:.    ....|:.:.:..|::|    |||:        |.
Human   206 DCIWTIK-----ATPKAKIYLRFLDYQMEHSNECKRNFVAVYDGSSS----IENL--------KA 253

  Fly   403 SHVAPILNGYYIRLR-GVFGM-------SSKLAIVYSVFNYLNCYIGSEFLCGNNHCISIRLHCD 459
            ...:.:.|...::.. ||..|       .|:..::::.|....| ..|.|.|.:|.||:..|.|:
Human   254 KFCSTVANDVMLKTGIGVIRMWADEGSRLSRFRMLFTSFVEPPC-TSSTFFCHSNMCINNSLVCN 317

  Fly   460 GFDHCGDGSDEPDSCEEDWAHLHHDRRWYSHKPNYYFPKIDQYPDLKTATGIF--IISTLG-IFG 521
            |..:|....|| :.|:|                             |...|:|  |..|.| |.|
Human   318 GVQNCAYPWDE-NHCKE-----------------------------KKKAGVFEQITKTHGTIIG 352

  Fly   522 VLSGWMVILYRMGVRARHQRELQSHLQTISELLDRQDEDRTPDEPPSYEAPPDYEEVIKVGMQQE 586
            :.||.:::|.                                              :|.:.:|
Human   353 ITSGIVLVLL----------------------------------------------IISILVQ-- 369

  Fly   587 LREPRRQRRARRAPPRDRSCSRAASNCTVQSVL-PLHRSCTLERDQEQPSTSAAAMTHAVAATDT 650
            :::||::..|         |..|.:....|.|. |.|......||:|..:..|          |.
Human   370 VKQPRKKVMA---------CKTAFNKTGFQEVFDPPHYELFSLRDKEISADLA----------DL 415

  Fly   651 TEDAEHVQTMAQRMLLATAI----CGTAGTSLPAAKESGQRVQSVGISTSPSSLSAGGELPTAGG 711
            :|:.::.|.|.:....:..|    ||:..:|:..::            |:.||:    |||....
Human   416 SEELDNYQKMRRSSTASRCIHDHHCGSQASSVKQSR------------TNLSSM----ELPFRND 464

  Fly   712 SA-TTPGSTADECTQGGDSLSISLTLGLPSTTAESPVTTDQNQLQKQSPEQTISNCTEHTFLKRS 775
            .| ..|..|.:                  ||..:|..|..|..   :.|||.:.:
Human   465 FAQPQPMKTFN------------------STFKKSSYTFKQGH---ECPEQALED---------- 498

  Fly   776 WLVVQQVP 783
             .|::::|
Human   499 -RVMEEIP 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Culd	NP_729364.1	CUB	200..298	CDD:238001	22/98 (22%)
Culd	NP_729364.1	LDLa	442..472	CDD:238060	12/29 (41%)
NETO2	NP_060562.3	CUB	<205..291	CDD:238001	23/102 (23%)
		LDLa	297..331	CDD:238060	13/35 (37%)
		CUB	45..158	CDD:238001	30/145 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910