DRSC/TRiP Functional Genomics Resources

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Protein Alignment Culd and SORL1

DIOPT Version :9

Sequence 1:NP_729364.1 Gene:Culd / 38946 FlyBaseID:FBgn0035880 Length:965 Species:Drosophila melanogaster
Sequence 2:NP_003096.2 Gene:SORL1 / 6653 HGNCID:11185 Length:2214 Species:Homo sapiens


Alignment Length:756 Identity:129/756 - (17%)
Similarity:210/756 - (27%) Gaps:288/756 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 TTAYR--SSPLVFKNDAVAGDVW-YQCSLELVTCAECVIRVAFTYANFSKSCGNTGGKSSMCPCE 125
            :.||.  |..:.:.|.....|.| |.....|    ||:.|:.|:            |:......:
Human   910 SAAYHLVSEDVKWPNGISVDDQWIYWTDAYL----ECIERITFS------------GQQRSVILD 958

  Fly   126 HIQFSEPPYDSTISGQEFCGDG----KVFRSK--------------TRTLQLKFFYRASNAHVFS 172
            ::..   ||...:...|...|.    .:||:.              |..:.:|.||:..|     
Human   959 NLPH---PYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKN----- 1015

  Fly   173 LQYFSERNVRIVSGS-------------PKQSIVGNGSTKSQPQVISTPYFPMA-----YPRDYG 219
                        :||             ||   ..|..:...|:.:|:...|..     .|:.|.
Human  1016 ------------TGSNACVPRPCSLLCLPK---ANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQ 1065

  Fly   220 IEHILTCEADNCQVRLDFTDFQLGLTSTLEIFDSNGQMLDSY-----------TGEHFRPPITV- 272
            :::....:.:|..:|..:.             .|||..::|.           ..:....|.|: 
Human  1066 LKNNTCVKQENTCLRNQYR-------------CSNGNCINSIWWCDFDNDCGDMSDERNCPTTIC 1117

  Fly   273 ---------SSGKSLLLQFRGNSATGVGFRAEVSFVSSKQLKDERLVPYTDCGGMVTGPGGAITM 328
                     .||..:.|.::.:.....|..::.|.....|.:.:.   |....||..........
Human  1118 DLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDE---YNCSSGMCIRSSWVCDG 1179

  Fly   329 MNMIENATDVRLFDCIWIIKPGNNYMMMKTH-ISLRVDDFYGMAARSELTIRQGTTSDAVEIE-- 390
            .|...:.:|......|:.....:|:.....| |..|      .|...:...:.|:..|.|..|  
Human  1180 DNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQR------WACDGDTDCQDGSDEDPVNCEKK 1238

  Fly   391 --NVMWPN----------NGL------SKESHVAPILNGYYIRLRGVFGMSSKLAIVYSVF--NY 435
              ....||          :||      |.|.|..|:...:    ......:.:..:.:|:.  ..
Human  1239 CNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHF----MDFVCKNRQQCLFHSMVCDGI 1299

  Fly   436 LNCYIGSE----------------------FLCGNNHCISIRLHCDGFDHCGDGSDEPD------ 472
            :.|..||:                      |.|.|..|||:...|||.|.|||.|||.:      
Human  1300 IQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTE 1364

  Fly   473 ----------SCEED------WAHLHHDRR-----WYSHK-------------------PNYYFP 497
                      .||..      |   ..||.     |...|                   ||||  
Human  1365 APNCSRYFQFRCENGHCIPNRW---KCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYY-- 1424

  Fly   498 KIDQYPDLKTATGIFIISTLGIFGVLSGWMVILYRMGVRARHQRELQSHLQTISELLDRQDEDRT 562
                    :.::|..::.|         |:...||                   :..|..||   
Human  1425 --------RCSSGTCVMDT---------WVCDGYR-------------------DCADGSDE--- 1450

  Fly   563 PDEPPSYEAPPDYEEVIKVGMQQELREPRRQRRARRAPPRDRSCSRAASNC-TVQSVLPLHRSCT 626
                   ||.|....|                .|...|.:...|.|....| ..::.:|..:.|.
Human  1451 -------EACPLLANV----------------TAASTPTQLGRCDRFEFECHQPKTCIPNWKRCD 1492

  Fly   627 LERDQEQPSTSAAAMTHA----VAATDTTEDAEHVQTMAQR 663
            ..:|.:.....|...||:    ::.....||.|....:::|
Human  1493 GHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSER 1533

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CuldNP_729364.1 CUB 200..298 CDD:238001 17/123 (14%)
LDLa 442..472 CDD:238060 17/51 (33%)
SORL1NP_003096.2 Cell attachment site. /evidence=ECO:0000255 63..65
VPS10 124..753 CDD:214740
BNR 1 136..147
BNR 2 232..243
BNR 3 441..452
BNR 4 521..532
BNR 5 562..573
LY 780..821 CDD:214531
LDL-receptor class B 1 800..843
LY 824..866 CDD:214531
LDL-receptor class B 2 844..887
LY 868..910 CDD:214531 129/756 (17%)
LDL-receptor class B 3 888..932 5/21 (24%)
Ldl_recept_b 890..929 CDD:278487 4/18 (22%)
LY 913..953 CDD:214531 12/55 (22%)
LDL-receptor class B 4 933..970 9/55 (16%)
LDL-receptor class B 5 971..1013 8/41 (20%)
LDLa 1078..1112 CDD:238060 5/46 (11%)
LDLa 1120..1153 CDD:238060 5/32 (16%)
Ldl_recept_a 1157..1192 CDD:278486 6/37 (16%)
LDLa 1198..1230 CDD:197566 6/37 (16%)
LDLa 1240..1271 CDD:238060 6/30 (20%)
LDLa 1281..1308 CDD:197566 4/26 (15%)
LDLa 1325..1359 CDD:238060 16/33 (48%)
LDLa 1373..1403 CDD:238060 7/32 (22%)
LDLa 1419..1453 CDD:238060 13/81 (16%)
LDLa 1471..1506 CDD:238060 7/34 (21%)
LDLa 1513..1546 CDD:197566 4/21 (19%)
FN3 1557..>1628 CDD:238020
FN3 1651..1742 CDD:238020
FN3 1749..1829 CDD:214495
FN3 1934..2021 CDD:238020
FN3 2025..2112 CDD:238020
Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000305|PubMed:16531402 2161..2164
Endocytosis signal. /evidence=ECO:0000255 2172..2177
Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000269|PubMed:17646382 2190..2214
Required for interaction with GGA1 and GGA2. /evidence=ECO:0000269|PubMed:11821067 2201..2214
DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000269|PubMed:20015111 2208..2212
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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