DRSC/TRiP Functional Genomics Resources

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Protein Alignment Culd and SORL1

DIOPT Version :10

Sequence 1:NP_729364.1 Gene:Culd / 38946 FlyBaseID:FBgn0035880 Length:965 Species:Drosophila melanogaster
Sequence 2:NP_003096.2 Gene:SORL1 / 6653 HGNCID:11185 Length:2214 Species:Homo sapiens


Alignment Length:756 Identity:129/756 - (17%)
Similarity:210/756 - (27%) Gaps:288/756 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    64 TTAYR--SSPLVFKNDAVAGDVW-YQCSLELVTCAECVIRVAFTYANFSKSCGNTGGKSSMCPCE 125
            :.||.  |..:.:.|.....|.| |.....|    ||:.|:.|:            |:......:
Human   910 SAAYHLVSEDVKWPNGISVDDQWIYWTDAYL----ECIERITFS------------GQQRSVILD 958

  Fly   126 HIQFSEPPYDSTISGQEFCGDG----KVFRSK--------------TRTLQLKFFYRASNAHVFS 172
            ::..   ||...:...|...|.    .:||:.              |..:.:|.||:..|     
Human   959 NLPH---PYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKN----- 1015

  Fly   173 LQYFSERNVRIVSGS-------------PKQSIVGNGSTKSQPQVISTPYFPMA-----YPRDYG 219
                        :||             ||   ..|..:...|:.:|:...|..     .|:.|.
Human  1016 ------------TGSNACVPRPCSLLCLPK---ANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQ 1065

  Fly   220 IEHILTCEADNCQVRLDFTDFQLGLTSTLEIFDSNGQMLDSY-----------TGEHFRPPITV- 272
            :::....:.:|..:|..:.             .|||..::|.           ..:....|.|: 
Human  1066 LKNNTCVKQENTCLRNQYR-------------CSNGNCINSIWWCDFDNDCGDMSDERNCPTTIC 1117

  Fly   273 ---------SSGKSLLLQFRGNSATGVGFRAEVSFVSSKQLKDERLVPYTDCGGMVTGPGGAITM 328
                     .||..:.|.::.:.....|..::.|.....|.:.:.   |....||..........
Human  1118 DLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDE---YNCSSGMCIRSSWVCDG 1179

  Fly   329 MNMIENATDVRLFDCIWIIKPGNNYMMMKTH-ISLRVDDFYGMAARSELTIRQGTTSDAVEIE-- 390
            .|...:.:|......|:.....:|:.....| |..|      .|...:...:.|:..|.|..|  
Human  1180 DNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQR------WACDGDTDCQDGSDEDPVNCEKK 1238

  Fly   391 --NVMWPN----------NGL------SKESHVAPILNGYYIRLRGVFGMSSKLAIVYSVF--NY 435
              ....||          :||      |.|.|..|:...:    ......:.:..:.:|:.  ..
Human  1239 CNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHF----MDFVCKNRQQCLFHSMVCDGI 1299

  Fly   436 LNCYIGSE----------------------FLCGNNHCISIRLHCDGFDHCGDGSDEPD------ 472
            :.|..||:                      |.|.|..|||:...|||.|.|||.|||.:      
Human  1300 IQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTE 1364

  Fly   473 ----------SCEED------WAHLHHDRR-----WYSHK-------------------PNYYFP 497
                      .||..      |   ..||.     |...|                   ||||  
Human  1365 APNCSRYFQFRCENGHCIPNRW---KCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYY-- 1424

  Fly   498 KIDQYPDLKTATGIFIISTLGIFGVLSGWMVILYRMGVRARHQRELQSHLQTISELLDRQDEDRT 562
                    :.::|..::.|         |:...||                   :..|..||   
Human  1425 --------RCSSGTCVMDT---------WVCDGYR-------------------DCADGSDE--- 1450

  Fly   563 PDEPPSYEAPPDYEEVIKVGMQQELREPRRQRRARRAPPRDRSCSRAASNC-TVQSVLPLHRSCT 626
                   ||.|....|                .|...|.:...|.|....| ..::.:|..:.|.
Human  1451 -------EACPLLANV----------------TAASTPTQLGRCDRFEFECHQPKTCIPNWKRCD 1492

  Fly   627 LERDQEQPSTSAAAMTHA----VAATDTTEDAEHVQTMAQR 663
            ..:|.:.....|...||:    ::.....||.|....:::|
Human  1493 GHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSER 1533

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CuldNP_729364.1 CUB 200..298 CDD:238001 17/123 (14%)
LDLa 442..472 CDD:238060 17/51 (33%)
SORL1NP_003096.2 Cell attachment site. /evidence=ECO:0000255 63..65
VPS10 124..753 CDD:214740
BNR 1 136..147
BNR 2 232..243
BNR 3 441..452
BNR 4 521..532
BNR 5 562..573
LY 780..821 CDD:214531
LDL-receptor class B 1 800..843
LY 824..866 CDD:214531
LDL-receptor class B 2 844..887
LY 868..910 CDD:214531 129/756 (17%)
LDL-receptor class B 3 888..932 5/21 (24%)
Ldl_recept_b 890..929 CDD:459654 4/18 (22%)
LY 913..953 CDD:214531 12/55 (22%)
LDL-receptor class B 4 933..970 9/55 (16%)
LY 953..993 CDD:214531 6/42 (14%)
LDL-receptor class B 5 971..1013 8/41 (20%)
LDLa 1078..1112 CDD:238060 5/46 (11%)
LDLa 1120..1153 CDD:238060 5/32 (16%)
Ldl_recept_a 1157..1192 CDD:395011 6/37 (16%)
LDLa 1198..1230 CDD:197566 6/37 (16%)
LDLa 1240..1271 CDD:238060 6/30 (20%)
LDLa 1281..1308 CDD:197566 4/26 (15%)
LDLa 1325..1359 CDD:238060 16/33 (48%)
LDLa 1373..1403 CDD:238060 7/32 (22%)
LDLa 1419..1453 CDD:238060 13/81 (16%)
LDLa 1471..1506 CDD:238060 7/34 (21%)
LDLa 1513..1546 CDD:197566 4/21 (19%)
FN3 1557..>1628 CDD:238020
FN3 1651..1742 CDD:238020
FN3 1703..>2099 CDD:442628
FN3 1934..2021 CDD:238020
Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000305|PubMed:16531402 2161..2164
Endocytosis signal. /evidence=ECO:0000255 2172..2177
Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000269|PubMed:17646382 2190..2214
Required for interaction with GGA1 and GGA2. /evidence=ECO:0000269|PubMed:11821067 2201..2214
DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000269|PubMed:20015111 2208..2212
Blue background indicates that the domain is not in the aligned region.

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