DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Culd and ldlrad3

DIOPT Version :9

Sequence 1:	NP_729364.1	Gene:	Culd / 38946	FlyBaseID:	FBgn0035880	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_001124079.1	Gene:	ldlrad3 / 570705	ZFINID:	ZDB-GENE-030131-1533	Length:	314	Species:	Danio rerio

Alignment Length:	279	Identity:	65/279 - (23%)
Similarity:	87/279 - (31%)	Gaps:	113/279 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   417 RGVFGMSSKLAIVYSVFNYLNCYIGSEFLCGNN-HCISIRLHCDGFDHCGDGSDEPDSCEEDWAH 480
            ||...:.||.|..:             |.|.|. |||..|..|:||..|.||||| |:|.   ||
Zfish    60 RGCLKLKSKCASTF-------------FSCANGVHCIIGRFQCNGFRDCPDGSDE-DNCT---AH 107

  Fly   481 --LHHDRRWY-------------------------------SHKPNYYFPKID----QYPDLKTA 508
              |....|::                               :..|.:....:|    .||.:..|
Zfish   108 PLLCSSLRFHCANGRCVDRSFLCNGQDNCQDNSDEENCLTTAESPEHMLGTLDYRLRYYPSITYA 172

  Fly   509 T-GIFIISTLGIFGVLSGWMVILYRMGVR-----------ARHQRELQSHLQTI--SELLDRQDE 559
            . |..||..|    |::...::|:....|           :.||..|.|.|..:  ..||   ..
Zfish   173 VIGSAIIFVL----VVALLALVLHHQRKRSVLLPQRVYRGSCHQPLLLSRLLIVERGHLL---HP 230

  Fly   560 DRTP----DEPPSY------------------------EAPPDYEEVIKVGMQQELREPRRQ--- 593
            .|.|    |.||||                        ..||.|||      .:|..|.:.|
Zfish   231 SRCPGAPADLPPSYSQAVRDSGRPVWFDLPPPPYPPPDREPPGYEE------PEEPAEAQTQTSV 289

  Fly   594 RRARRAPPRDRSCSRAASN 612
            ......||...|.:..:|:
Zfish   290 TSVEETPPAPPSPALPSSS 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Culd	NP_729364.1	CUB	200..298	CDD:238001
Culd	NP_729364.1	LDLa	442..472	CDD:238060	16/30 (53%)
ldlrad3	NP_001124079.1	LDLa	30..62	CDD:238060	1/1 (100%)
		LDLa	69..104	CDD:238060	18/48 (38%)
		LDLa	111..145	CDD:238060	1/33 (3%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900