DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Culd and lrp5

DIOPT Version :9

Sequence 1:NP_729364.1 Gene:Culd / 38946 FlyBaseID:FBgn0035880 Length:965 Species:Drosophila melanogaster
Sequence 2:XP_009296098.1 Gene:lrp5 / 568518 ZFINID:ZDB-GENE-050518-2 Length:1615 Species:Danio rerio


Alignment Length:393 Identity:80/393 - (20%)
Similarity:121/393 - (30%) Gaps:123/393 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   436 LNCYIGS--EFLCGNNHCISIRLHCDGFDHCGDGSDE---------------------------- 470
            :||.|.|  :|.|....|:.|::.|:|...|.|||||                            
Zfish  1295 MNCPICSKLQFQCDKGQCVDIQVRCNGEPDCADGSDEQDCETICLSNQFRCGNSQCILKKQQCDS 1359

  Fly   471 -PDSCEEDWAHLHHDRRWYSHKPNYYFPKIDQYPDLKTATGIFIISTLGIFGVLSGWMVILYRMG 534
             ||..:|.      |.|:....|    |..| .|...:..|..|...|.:| |:.|...:..|:.
Zfish  1360 FPDCTDES------DERFCDFPP----PPND-LPRHTSTIGPVIGIILSVF-VMGGMCFVCQRVV 1412

  Fly   535 VRARHQRELQSHLQTISELLDRQDEDRTPDEPPSYEAPPD--YEEVIKVGMQQELREPRRQRRAR 597
            .|         |.:..:.....:....||..|.::.||.:  :.:.|..|.............:.
Zfish  1413 CR---------HYKGPNGGFPHEYISGTPHVPLNFIAPTNSQHGKGISCGKSMMSSVSLMGSSSS 1468

  Fly   598 RAPPRDRSCSRAASNCTVQSVLPLHRSCTLERDQEQPSTSAAAMTHAVAATDTTEDAEHVQTMAQ 662
            .||..||:....||:                                 :::.:|:.|.:.|.:..
Zfish  1469 GAPLYDRNHVTGASS---------------------------------SSSSSTKGAFYPQMLNP 1500

  Fly   663 RMLLATAICGTAGTSLPAAKESGQRVQSVGISTSPSS-------LSAGGELPTAGGSATTPGST- 719
                         ...||...|....:....|.|||:       |..|...|      |||.|| 
Zfish  1501 -------------PPSPATDRSLYNAEVFYSSNSPSTTRSYRPYLMRGVAPP------TTPCSTD 1546

  Fly   720 ---ADECTQGGDSLSISLTLGLPSTTAESPVTTDQNQLQKQSPEQTISNCTEHTFLKRSWLVVQQ 781
               :|..|....|....:.|...|.....|.|.   :.|..|.|:   :|......:||:..:..
Zfish  1547 VCDSDYTTSRWKSNKYYMDLNSDSDPYPPPPTP---RSQYMSAEE---SCPPSPSTERSYFHLCP 1605

  Fly   782 VPP 784
            .||
Zfish  1606 PPP 1608

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CuldNP_729364.1 CUB 200..298 CDD:238001
LDLa 442..472 CDD:238060 13/60 (22%)
lrp5XP_009296098.1 LY 105..147 CDD:214531
Ldl_recept_b 168..208 CDD:278487
LY 192..234 CDD:214531
LY 235..269 CDD:214531
FXa_inhibition 304..341 CDD:291342
Ldl_recept_b 390..429 CDD:278487
LY 413..455 CDD:214531
LY 456..499 CDD:214531
LY 501..542 CDD:214531
LY 544..583 CDD:214531
FXa_inhibition 610..645 CDD:291342
LY 674..714 CDD:214531
LY 717..757 CDD:214531
LY 758..800 CDD:214531
LY 802..843 CDD:214531
LY 845..884 CDD:214531
FXa_inhibition 911..946 CDD:291342
LY 974..1013 CDD:214531
LY 1106..1148 CDD:214531
FXa_inhibition 1219..1255 CDD:291342
LDLa 1261..1297 CDD:238060 0/1 (0%)
LDLa 1300..1334 CDD:238060 13/33 (39%)
LDLa 1338..1372 CDD:238060 5/39 (13%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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