Protein Alignment Culd and LRP1B

DIOPT Version :9

• Sequence 1: NP_729364.1
• Gene: Culd / 38946
• FlyBaseID: FBgn0035880
• Length: 965
• Species: Drosophila melanogaster
• Sequence 2: NP_061027.2
• Gene: LRP1B / 53353
• HGNCID: 6693
• Length: 4599
• Species: Homo sapiens
• Alignment Length: 257
• Identity: 52/257 - (20%)
• Similarity: 71/257 - (27%)
• Gaps: 119/257 - (46%)

  Fly   346 IIKPGNNYMMMKTHISLRVDDFYGMAARSELTIRQGTTSDAVEIENVMWPNNGLSKESHVAPI-- 408
            ::.|.|.:|.........:||..|   |.|.....|..........::|| |||:.:.|...:
Human   651 VVDPVNGWMYWTDWEEDEIDDSVG---RIEKAWMDGFNRQIFVTSKMLWP-NGLTLDFHTNTLYW 711

  Fly   409 LNGYYIRLRGVFGMSSKLAIVYS----------------VF--NYLN------------------ 437
            .:.||..:..||...:...||||                ||  :|:|
Human   712 CDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEVTLLRH 776

  Fly   438 ---------------------CYIGS--------------------------------------- 442
                                 |.:.:
Human   777 ERPPLFGLQIYDPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADNQLLDENGTTCTFNPGEAL 841

  Fly   443 -------EFLCGNNHCISIRLHCDGFDHCGDGSDEPD------SCEEDWAHLHHDR----RW 487
                   ||.|.|.|||..|..|||.|.|.|||||..      ||.:|.....::|    ||
Human   842 PHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRW 903

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Culd	NP_729364.1	CUB	200..298	CDD:238001
		LDLa	442..472	CDD:238060	18/75 (24%)
LRP1B	NP_061027.2	FXa_inhibition	165..193	CDD:291342
		NHL	282..459	CDD:302697
		NHL repeat	285..321	CDD:271320
		LDL-receptor class B 1	295..337
		LY	319..361	CDD:214531
		NHL repeat	328..367	CDD:271320
		LDL-receptor class B 2	338..381
		NHL repeat	371..406	CDD:271320
		LDL-receptor class B 3	382..425
		NHL repeat	415..445	CDD:271320
		FXa_inhibition	483..516	CDD:291342
		LY	548..590	CDD:214531
		LDL-receptor class B 4	568..610
		LY	591..630	CDD:214531
		LDL-receptor class B 5	611..656		1/4 (25%)
		LY	637..686	CDD:214531	9/37 (24%)
		LDL-receptor class B 6	657..706		12/52 (23%)
		LY	687..729	CDD:214531	10/42 (24%)
		LDL-receptor class B 7	707..750		8/42 (19%)
		FXa_inhibition	798..833	CDD:291342	1/34 (3%)
		LDLa	886..919	CDD:238060	5/18 (28%)
		LDLa	926..958	CDD:197566
		LDLa	1006..1038	CDD:238060
		LDLa	1053..1088	CDD:238060
		LDLa	1097..1131	CDD:238060
		LDLa	1136..1169	CDD:238060
		FXa_inhibition	1176..1212	CDD:291342
		LY	1280..1318	CDD:214531
		LDL-receptor class B 8	1300..1346
		LY	1327..1367	CDD:214531
		LDL-receptor class B 9	1347..1389
		LY	1371..1414	CDD:214531
		LDL-receptor class B 10	1390..1436
		LY	<1426..1458	CDD:214531
		LDL-receptor class B 11	1437..1480
		LDL-receptor class B 12	1481..1522
		LDL-receptor class B 13	1618..1660
		Ldl_recept_b	1618..1657	CDD:278487
		LY	1641..1683	CDD:214531
		LDL-receptor class B 14	1661..1704
		LY	1685..1724	CDD:214531
		LDL-receptor class B 15	1705..1744
		LY	<1735..1766	CDD:214531
		LDL-receptor class B 16	1745..1787
		FXa_inhibition	1838..1874	CDD:291342
		NHL	1913..2138	CDD:302697
		NHL repeat	1913..1952	CDD:271320
		LDL-receptor class B 17	1922..1964
		LY	1947..1987	CDD:214531
		NHL repeat	1957..1994	CDD:271320
		LDL-receptor class B 28	1965..2007
		NHL repeat	1998..2036	CDD:271320
		LDL-receptor class B 19	2008..2051
		Ldl_recept_b	2008..2048	CDD:278487
		LY	2033..2075	CDD:214531
		NHL repeat	2042..2080	CDD:271320
		LDL-receptor class B 20	2052..2095
		NHL repeat	2089..2128	CDD:271320
		FXa_inhibition	2147..2182	CDD:291342
		LDL-receptor class B 21	2239..2280
		LDL-receptor class B 22	2281..2329
		LDL-receptor class B 23	2330..2374
		Ldl_recept_b	2330..2371	CDD:278487
		LY	2355..2397	CDD:214531
LDL-receptor class B 24	2375..2416
LDL-receptor class B 25	2417..2459
LDLa	2514..2543	CDD:238060
LDLa	2552..2586	CDD:238060
LDLa	2591..2625	CDD:238060
LDLa	2682..2716	CDD:238060
LDLa	2720..2753	CDD:238060
LDLa	2760..2793	CDD:197566
LDLa	2844..2877	CDD:197566
LDLa	2891..2925	CDD:238060
cEGF	2948..2971	CDD:289433
EGF_CA	2968..2998	CDD:214542
LY	3035..3079	CDD:214531
LDL-receptor class B 26	3055..3098
LY	3080..3118	CDD:214531
LDL-receptor class B 27	3099..3141
LY	3123..3164	CDD:214531
LDL-receptor class B 28	3142..3185
LY	3167..3206	CDD:214531
LDL-receptor class B 29	3186..3224
LDL-receptor class B 30	3225..3268
FXa_inhibition	3277..3313	CDD:291342
LDLa	3317..3348	CDD:197566
LDLa	3357..3391	CDD:238060
LDLa	3396..3431	CDD:238060
LDLa	3436..3471	CDD:238060
LDLa	3476..3510	CDD:238060
LDLa	3515..3549	CDD:238060
LDLa	3553..3587	CDD:238060
LDLa	3594..3628	CDD:238060
LDLa	3632..3667	CDD:238060
LDLa	3674..3706	CDD:238060
LDLa	3721..3751	CDD:238060
LDLa	3762..3796	CDD:238060
EGF_CA	3844..3878	CDD:214542
LDL-receptor class B 31	3933..3980
LDL-receptor class B 32	3981..4038
LDL-receptor class B 33	4039..4082
Ldl_recept_b	4039..4079	CDD:278487
LY	4063..4102	CDD:214531
LDL-receptor class B 34	4083..4127
Endocytosis signal. /evidence=ECO:0000255	4492..4495
Endocytosis signal. /evidence=ECO:0000255	4559..4562

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900