Sequence 1: | NP_729364.1 | Gene: | Culd / 38946 | FlyBaseID: | FBgn0035880 | Length: | 965 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_002327.2 | Gene: | LRP6 / 4040 | HGNCID: | 6698 | Length: | 1613 | Species: | Homo sapiens |
Alignment Length: | 938 | Identity: | 191/938 - (20%) |
---|---|---|---|
Similarity: | 270/938 - (28%) | Gaps: | 378/938 - (40%) |
- Green bases have known domain annotations that are detailed below.
Fly 30 SSYRDLDICNHWDGRRHFLELGSPAGEVHARNVTTTAYRSSPLVFKNDAVAGDVWYQCSLELVTC 94
Fly 95 AECVIRVAFTYANFSKSCGNTGGKSSMCPCEHIQFSEPPYDSTISGQEFCGDGKVFRSKTRTLQL 159
Fly 160 KFFYR-ASNAHVFS--------LQYFSERNVRIVSGSP----------KQSIV----GNGSTKSQ 201
Fly 202 PQVISTPYFPM-AYPRDYGIE----HIL-TCEADNC--QVRLDFTDFQLGLTSTLEIFDSNGQML 258
Fly 259 DSYTGEHFRP-PITVSSGKSLL----LQFRG---NSATGVGFRAEVSFVS--SKQL--------- 304
Fly 305 ------KDERLVPYTDCGGM---------VTGPGGAITMMNMIENATDVRLFDCIWIIKPGNNYM 354
Fly 355 MMKTHISLRVDDFYGMAARSELTIRQGTTSD--AVEIENVM--------WPNNGLSKESHVAPIL 409
Fly 410 NGYYIRLRGVFGMSSKLAIV------------------YSVF----------------------- 433
Fly 434 NYLNCYIGSE--FLCGNNHCISIRLHCDGFDHCGDGSDEPDSCEEDWAHLHHDRRWYSHKPNYYF 496
Fly 497 PKIDQYPDLKTATGIFIISTLGIFGVLSGWMVILYRMGVRARHQRELQSHLQTISELLDRQDE-D 560
Fly 561 RTPDEPPSYEAPPDYEEVIKVGMQQELREPRRQRRARRAPPRDRSCSRAASNCTVQSVLPLHRSC 625
Fly 626 TLERDQEQPSTSAAAMTHAVAATDTTEDAEHVQTMAQRMLLATAICGTAGTSLPAAKESGQRVQS 690
Fly 691 -----------VGISTSPSSLSAGGELP-------------TAGGSATTPGSTADECTQGGDSLS 731
Fly 732 ISLTLGL---------PSTTAESPVTTDQNQLQKQSPEQTISNCTEHTFLKRSWLVVQQVPP--- 784
Fly 785 ------GRGYRVRRLRHTFSSPEAFTSD 806 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
Culd | NP_729364.1 | CUB | 200..298 | CDD:238001 | 31/113 (27%) |
LDLa | 442..472 | CDD:238060 | 14/31 (45%) | ||
LRP6 | NP_002327.2 | Beta-propeller 1 | 20..275 | ||
NHL | 55..272 | CDD:302697 | |||
NHL repeat | 55..93 | CDD:271320 | |||
LY | 89..127 | CDD:214531 | |||
NHL repeat | 97..132 | CDD:271320 | |||
NHL repeat | 140..176 | CDD:271320 | |||
Ldl_recept_b | 150..190 | CDD:278487 | |||
LY | 175..216 | CDD:214531 | |||
NHL repeat | 181..217 | CDD:271320 | |||
NHL repeat | 226..253 | CDD:271320 | |||
LDL-receptor class B 5 | 237..276 | ||||
FXa_inhibition | 286..323 | CDD:291342 | |||
Beta-propeller 2 | 328..589 | ||||
LY | 353..393 | CDD:214531 | |||
LY | 397..437 | CDD:214531 | |||
LY | 438..481 | CDD:214531 | |||
LY | 483..524 | CDD:214531 | |||
LY | 525..558 | CDD:214531 | |||
FXa_inhibition | 592..627 | CDD:291342 | |||
Beta-propeller 3 | 631..890 | 11/53 (21%) | |||
LY | 656..694 | CDD:214531 | |||
LY | 697..739 | CDD:214531 | |||
LY | 740..783 | CDD:214531 | |||
LY | 783..825 | CDD:214531 | |||
LY | 827..866 | CDD:214531 | 6/27 (22%) | ||
FXa_inhibition | 893..929 | CDD:291342 | 9/56 (16%) | ||
Beta-propeller 4 | 933..1202 | 71/313 (23%) | |||
LY | 958..998 | CDD:214531 | 9/39 (23%) | ||
Ldl_recept_b | 1069..1110 | CDD:278487 | 11/40 (28%) | ||
LY | 1094..1136 | CDD:214531 | 10/41 (24%) | ||
FXa_inhibition | 1207..1243 | CDD:291342 | 7/44 (16%) | ||
LDLa | 1249..1285 | CDD:238060 | 2/35 (6%) | ||
LDLa | 1288..1322 | CDD:238060 | 14/34 (41%) | ||
LDLa | 1326..1360 | CDD:238060 | 12/64 (19%) | ||
PPPSP motif A | 1487..1493 | 2/5 (40%) | |||
PPPSP motif B | 1527..1534 | 2/6 (33%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1556..1613 | 3/4 (75%) | |||
PPPSP motif C | 1568..1575 | ||||
PPPSP motif D | 1588..1593 | ||||
PPPSP motif E | 1603..1610 | ||||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_KOG1215 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 1 | 1.100 | - | - | O | PTHR24270 |
Phylome | 0 | 0.000 | Not matched by this tool. | |||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
2 | 2.000 |