Protein Alignment Culd and LRP3

DIOPT Version :9

• Sequence 1: NP_729364.1
• Gene: Culd / 38946
• FlyBaseID: FBgn0035880
• Length: 965
• Species: Drosophila melanogaster
• Sequence 2: XP_005259002.1
• Gene: LRP3 / 4037
• HGNCID: 6695
• Length: 785
• Species: Homo sapiens
• Alignment Length: 571
• Identity: 126/571 - (22%)
• Similarity: 178/571 - (31%)
• Gaps: 143/571 - (25%)

  Fly   229 DNCQVRLDFTDFQLGLTSTLEIFDSNGQMLD------SYTGEHFRPPITVSSGK-SLLLQFRGNS 286
            |:.:|.|.. :.:||....:::::..|:..|      ||...|....:..:.|: ::....|..|
Human   290 DSRRVLLQL-ELRLGYDDYVQVYEGLGERGDRLLQTLSYRSNHRPVSLEAAQGRLTVAYHARARS 353

  Fly   287 ATGVGFRAEVSFVSSKQLKDERLVPYTDCGGMVTGPGGAITMMNMIENATDVRLFDCIWIIKPGN 351
            | |.||.|      :.|:|...|.....||......||::......   ::.:..|..|....|.
Human   354 A-GHGFNA------TYQVKGYCLPWEQPCGSSSDSDGGSLGDQGCF---SEPQRCDGWWHCASGR 408

  Fly   352 NYMMMKTHISLRVDDFYGMAARSELTIRQGTTSDAVEIENVMWPNNGLSKESHVAPILNGYYIRL 416
            :    :........|.|.....|.|..   |.:|..        ||..|...
Human   409 D----EQGCPACPPDQYPCEGGSGLCY---TPADRC--------NNQKSCPD------------- 445

  Fly   417 RGVFGMSSKLAIVYSVFNYLNCYIGSEFLCGNNHCISIRLHCDGFDHCGDGSDEPDSCEEDWAHL 481
                |...|        |..:|..|: |.||.|.||.....|||.:.|.|||||
Human   446 ----GADEK--------NCFSCQPGT-FHCGTNLCIFETWRCDGQEDCQDGSDE----------- 486

  Fly   482 HHDRRWYSHKPNYYFPKIDQYPDLKTATGIFIISTL-GIFGVLS-GWMVILYRMGVRARHQRELQ 544
                    |......|:       |..|...|.|.: |:..|:: |....||.:..:....|..|
Human   487 --------HGCLAAVPR-------KVITAALIGSLVCGLLLVIALGCAFKLYSLRTQEYRSRAAQ 536

  Fly   545 S--HLQTISELLDRQDEDRTPDEPPSYEAPPDYEEVIKVGM-----------------QQELREP 590
            |  ...|.|...:.| ..|...|....||||.|.::|..|:                 .|.||..
Human   537 SCRPPPTASRAFETQ-MTRLEAEFVRREAPPSYGQLIAQGLIPPVEDFPVYSASQASVLQNLRTA 600

  Fly   591 -RRQRR---ARRAPPRDRSCSRAASNCTVQSVLPLHRSCTLERDQEQPSTSAAAMTHAVAATDTT 651
             |||.|   :||.|.| |...|..:..       .||. ...|.| .|..:||..:..|......
Human   601 MRRQMRRHASRRGPSR-RRLGRLWNRL-------FHRP-RAPRGQ-IPLLTAARPSQTVLGDGFL 655

  Fly   652 EDAEHVQTMAQRMLLATAICGTAGTSLPAAKESGQRVQSVGISTSPSSLSAGGELPTAGGSATTP 716
            :.|..........|:.|.....||...|:|.   .|...||.|..|        ||:
Human   656 QPAPGAAPDPPAPLMDTGSTRAAGDRPPSAP---GRAPEVGPSGPP--------LPS-------- 701

  Fly   717 GSTADECTQGGDSLSISLTLGLPSTTAESPVTTDQNQLQKQSPEQTISNCT 767
            |....||........:...   |.....:|....:.....|.|...:|..:
Human   702 GLRDPECRPVDKDRKVCRE---PLVDGPAPADAPREPCSAQDPHPQVSTAS 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Culd	NP_729364.1	CUB	200..298	CDD:238001	18/75 (24%)
		LDLa	442..472	CDD:238060	15/29 (52%)
LRP3	XP_005259002.1	CUB	43..156	CDD:238001
		LDLa	166..200	CDD:238060
		LDLa	212..249	CDD:238060
		CUB	254..364	CDD:238001	18/81 (22%)
		LDLa	416..452	CDD:238060	11/71 (15%)
		LDLa	455..489	CDD:238060	18/53 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900