DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Culd and Lrp4

DIOPT Version :9

Sequence 1:	NP_729364.1	Gene:	Culd / 38946	FlyBaseID:	FBgn0035880	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_727914.1	Gene:	Lrp4 / 32552	FlyBaseID:	FBgn0030706	Length:	2009	Species:	Drosophila melanogaster

Alignment Length:	801	Identity:	142/801 - (17%)
Similarity:	205/801 - (25%)	Gaps:	356/801 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 WDGRRHFLELGSPA--GEVHARNVTTTAYRSSPLVFKNDAVAGDVWYQCSLELVTCAECVIRVAF 103
            ||..:| .:|.|.|  |.:.|.|.:           :.|        |.|.||....|.:..|:
  Fly    47 WDWNKH-KQLHSDARIGHLEAGNES-----------RED--------QLSEELSKFGEKLFPVS- 90

  Fly   104 TYANFSKSCGNT-----GGKSSMCPCEHIQFSEPPYDSTISGQEFCGDGKVFRS----KTRTLQL 159
            .|..:.::..::     .|:..:    |...|..|..:.|||.....|...||:    :.||
  Fly    91 NYPPYQQNNEDSQEVHHSGEGRL----HTMESSVPSKTRISGGTNSNDTPKFRNIGAQRGRT--- 148

  Fly   160 KFFYRASNAHVFSLQYFSERNVRIVSGSPKQSIVGNGSTKSQPQVISTPYFPMAYPRDYGIEHIL 224
                          :....|....:|...:...:|..|.|.:|..::........|...| |...
  Fly   149 --------------EIAGIRETDRISSRGRDGFIGGPSNKQKPFRVNLAVLVQDDPSQPG-ETYS 198

  Fly   225 TC----EAD-NCQVRLDFTDFQLGLTSTLEIFDSNGQMLDSYTGEHFRPPITVSSGKSLLLQFR- 283
            .|    |:| ||....|..              .|.|.....||.|...|.|          ||
  Fly   199 NCQNSNESDENCNPEEDAV--------------PNLQRDCEKTGIHVMCPRT----------FRC 239

  Fly   284 --------GNSATGVGFRAEVSFVSSKQLKDERLVPYTDCGGMVTGPGGAITMMNMIENATDVRL 340
                    |:...|             ...||     |.||...              |.||.:
  Fly   240 ISKYWLCDGDDDCG-------------DYSDE-----THCGART--------------NCTDDQ- 271

  Fly   341 FDCIWIIKPGNNYMMMKTHISLRVDDFYGMAARSELTIRQGTTSDAVEIENVMWPNNG------L 399
            |:|:      |.:.:.:|                                   |..:|      .
  Fly   272 FECL------NGFCIPRT-----------------------------------WVCDGENDCKDF 295

  Fly   400 SKESHVAPILNGYYIRLRGVFGMSSKLAIVYSVFNYLNCYIGSEFLCGNNHCISIRLHCDGFDHC 464
            |.|:|.                            |...| ....|.|.:.:|||:...|||...|
  Fly   296 SDETHC----------------------------NRTTC-TDEHFTCNDGYCISLAFRCDGEHDC 331

  Fly   465 GDGSDE------PDSCEEDWAHLHHDRRWYSHKPNYYFPKIDQYPDLKTATGIFIISTLGIFGVL 523
            .|.|||      .:||.|.                          :.|...|      ||..|..
  Fly   332 NDNSDELKCAAVINSCPEG--------------------------EFKCRGG------LGGAGGP 364

  Fly   524 SGWMVILYRMGVRARHQRELQSHLQTISELLDRQDEDRTPDEPPSYEAPPDYEEVIKVGMQQELR 588
            || ..||.|.            .....::..|..||:..|.:|
  Fly   365 SG-QCILNRF------------RCDGDNDCGDWSDEENCPQKP---------------------- 394

  Fly   589 EPRRQRRARRAPPRDRSCSRAASNCTVQSVLPLHRSCTLERDQEQPSTSAAAMTHAVAATDTTED 653
                           ..|:.....|...:.:|....|..|:|                 .|..||
  Fly   395 ---------------SLCTSNEYKCADGTCIPKRWKCDKEQD-----------------CDGGED 427

  Fly   654 --------AEHVQTMAQ--------RMLLATAICGTAGTSLPAAKE-----------------SG 685
                    :||..|...        |.:|.|.:|.  |....||.|                 :.
  Fly   428 ENDCGSLGSEHPLTCGSDEFTCNNGRCILKTWLCD--GYPDCAAGEDEVECHLQCDLGQFLCPTK 490

  Fly   686 QRVQSVGISTSPSSLSAG-GELPTAGGSATTPGSTADECTQGG--DSLSISLTLGLPSTTAESPV 747
            |.:.::.|......:..| .|.|.....|..|...  :|::..  :.|.|..|.|..........
  Fly   491 QNLTNLKICVHQKHICDGHNECPAGEDEADCPKER--KCSEPSPCEQLCIETTAGSNECACRLGY 553

  Fly   748 TTDQNQLQKQSPEQTISNCTE 768
            ..|:|::          |||:
  Fly   554 VMDKNKV----------NCTD 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Culd	NP_729364.1	CUB	200..298	CDD:238001	21/111 (19%)
Culd	NP_729364.1	LDLa	442..472	CDD:238060	13/35 (37%)
Lrp4	NP_727914.1	LDLa	267..301	CDD:238060	10/75 (13%)
		LDLa	306..340	CDD:238060	14/34 (41%)
		LDLa	347..390	CDD:238060	15/87 (17%)
		LDLa	397..431	CDD:238060	9/50 (18%)
		LDLa	442..476	CDD:238060	8/35 (23%)
		LDLa	480..521	CDD:238060	6/40 (15%)
		FXa_inhibition	576..604	CDD:291342
		LY	634..671	CDD:214531
		NHL	<656..793	CDD:302697
		LY	680..714	CDD:214531
		NHL repeat	681..722	CDD:271320
		NHL repeat	726..760	CDD:271320
		LY	761..803	CDD:214531
		NHL repeat	769..793	CDD:271320
		FXa_inhibition	882..912	CDD:291342
		LY	946..985	CDD:214531
		NHL	<967..1142	CDD:302697
		LY	988..1030	CDD:214531
		NHL repeat	998..1037	CDD:271320
		NHL repeat	1038..1080	CDD:271320
		NHL repeat	1084..1119	CDD:271320
		FXa_inhibition	1185..1220	CDD:291342
		NHL	1260..>1445	CDD:302697
		NHL repeat	1260..1296	CDD:271320
		NHL repeat	1302..1337	CDD:271320
		NHL repeat	1345..1383	CDD:271320
		FXa_inhibition	<1499..1525	CDD:291342
		LY	1600..1640	CDD:214531
		LY	1643..1686	CDD:214531
		LY	1688..1729	CDD:214531
		FXa_inhibition	1801..>1825	CDD:291342
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24270
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.000