Protein Alignment Culd and Lrp6

DIOPT Version :10

• Sequence 1: NP_729364.1
• Gene: Culd / 38946
• FlyBaseID: FBgn0035880
• Length: 965
• Species: Drosophila melanogaster
• Sequence 2: NP_001388749.1
• Gene: Lrp6 / 312781
• RGDID: 1304749
• Length: 1613
• Species: Rattus norvegicus
• Alignment Length: 941
• Identity: 193/941 - (20%)
• Similarity: 270/941 - (28%)
• Gaps: 384/941 - (40%)

  Fly    30 SSYRDLDICNHWDGRRHFLELGSPAGEVHARNVTTTAYRSSPLVFKNDAVAGDVWYQCSLELVTC 94
            :.|:|......| .||........:|:..........|....|||.:...||  |.:|:.....|
  Rat   839 TQYQDYIYWTDW-SRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQAG--WNECASSNGHC 900

  Fly    95 AECVIRVAFTYANFSKSCGNTGGKSSMCPCEHIQFSEPPYDSTISGQEFCGDGKVFRSKTRTLQL 159
            :...:.|.            .||  .:|.|       |.:.|..:....|.....|        |
  Rat   901 SHLCLAVP------------VGG--FVCGC-------PAHYSLNADNRTCSAPTTF--------L 936

  Fly   160 KFFYR-ASNAHVFS--------LQYFSERNVRIVSGSP----------KQSIV-------GNGST 198
            .|..: |.|..|..        |...|.||||.:...|          :|:::       |.|.|
  Rat   937 LFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGGQGFT 1001

  Fly   199 KSQPQVISTPYFPM-AYPRDYGIE----HIL-TCEADNC--QVRLDFTDFQLGLTSTLEIFDSNG 255
               ..|.|.|...: ..|.|..|:    :|. ||||.|.  ..|||..              |.|
  Rat  1002 ---VVVSSVPNQNLEIQPYDLSIDIYSRYIYWTCEATNVIDVTRLDGR--------------SVG 1049

  Fly   256 QMLDSYTGEHFRP-PITVSSGKSLL----LQFRG---NSATGVGFRAEVSFVS--SKQL------ 304
            .:|   .||..|| .|.|:..|..:    ||.|.   ..|...|...||.|.|  ||.:
  Rat  1050 VVL---KGEQDRPRAIVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPVALALDS 1111

  Fly   305 ---------KDERLVPYTDCGGM---------VTGPGGAITMMNMIENATDVRLFDCIWIIKPGN 351
                     .|.|.:..:|..|.         :..|.|    :.:.||          |:
  Rat  1112 KLSRLFWADSDLRRIESSDLSGANRIVLEDSNILQPVG----LTVFEN----------WL----- 1157

  Fly   352 NYMMMKTHISLRVDDFYGMAARSELTIRQGTTSD--AVEIENVM--------WPNNGLSKESHVA 406
             |.:.|....:...|..|...|:::..|....||  ||:..|:.        ..|.|.   ||:.
  Rat  1158 -YWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQEYRQHPCAQDNGGC---SHIC 1218

  Fly   407 PILNGYYIRLRGVFGMSSKLAIV------------------YSVF-------------------- 433
                  .::..|....|..:.:|                  ::.|
  Rat  1219 ------LVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGDIDCIPVAWRCDGFTECE 1277

  Fly   434 ---NYLNCYIGSE--FLCGNNHCISIRLHCDGFDHCGDGSDEPDSCEEDWAHLHHDRRWYSHKPN 493
               :.|||.:.||  |.|.:..||...|.|:|..:|.|.||| .:||
  Rat  1278 DHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDE-KNCE------------------ 1323

  Fly   494 YYFPKIDQYPDLKTATGIFIISTLGIFGVLSGWMVILYRMGVRARHQRELQSHLQTISELLDRQD 558
             ....|||:   :.|.|..:                       .:|::  ..|....|   ||.|
  Rat  1324 -VLCLIDQF---RCANGQCV-----------------------GKHKK--CDHNVDCS---DRSD 1356

  Fly   559 E-DRTPDEPPSYEAPPDYEEVIKVGMQQELREPRRQRRARRAPPRDRSCSRAASNCTVQSVLPLH 622
            | |..|.|.|                               ||        .|:| ||.||:
  Rat  1357 ELDCYPTEEP-------------------------------AP--------QATN-TVGSVI--- 1378

  Fly   623 RSCTLERDQEQPSTSAAAMTHAVAATDTTEDAEHVQTMAQRMLLATAICGTAGTSLPAAKESGQR 687
                           ...:|..|:.|        :..:.||||     |       |..|..|:.
  Rat  1379 ---------------GVIVTIFVSGT--------IYFICQRML-----C-------PRMKGDGET 1408

  Fly   688 VQS-----------VGISTSPSSLSAGGELP-------------TAGGSATTPGSTADECTQGGD 728
            :.:           :|....|||||  |.||             ..|||:..|...|.  ..|..
  Rat  1409 MTNDYVVHGPASVPLGYVPHPSSLS--GSLPGMSRGKSMISSLSIMGGSSGPPYDRAH--VTGAS 1469

  Fly   729 SLSISLTLGL---------PSTTAESPVTTDQNQLQKQSPEQTISNCTEHTFLKRSWLVVQQVPP 784
            |.|.|.|.|.         ||...|....|.:......||.      |..::..|.:......||
  Rat  1470 SSSSSSTKGTYFPAILNPPPSPATERSHYTMEFGYSSNSPS------THRSYSYRPYSYRHFAPP 1528

  Fly   785 ---------GRGYRVRRLRHTFSSPEAFTSD 806
                     ...|...|...:.::.:.:|||
  Rat  1529 TTPCSTDVCDSDYAPSRRMTSVATAKGYTSD 1559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Culd	NP_729364.1	CUB	200..298	CDD:238001	32/113 (28%)
		LDLa	442..472	CDD:238060	14/31 (45%)
Lrp6	NP_001388749.1	YncE	1..204	CDD:442618
		LY	89..127	CDD:214531
		Ldl_recept_b	150..191	CDD:459654
		LY	175..216	CDD:214531
		LY	217..251	CDD:214531
		FXa_inhibition	286..323	CDD:464251
		LY	353..393	CDD:214531
		LY	397..437	CDD:214531
		Ldl_recept_b	458..499	CDD:459654
		LY	483..524	CDD:214531
		LY	525..558	CDD:214531
		FXa_inhibition	592..627	CDD:464251
		YncE	<654..813	CDD:442618
		LY	697..739	CDD:214531
		LY	827..866	CDD:214531	6/27 (22%)
		FXa_inhibition	893..929	CDD:464251	9/56 (16%)
		LY	958..998	CDD:214531	8/39 (21%)
		YncE	<968..1075	CDD:442618	31/126 (25%)
		LY	1094..1136	CDD:214531	10/41 (24%)
		FXa_inhibition	1207..1243	CDD:464251	7/44 (16%)
		LDLa	1249..1285	CDD:238060	2/35 (6%)
		LDLa	1288..1322	CDD:238060	14/34 (41%)
		LDLa	1326..1360	CDD:238060	12/64 (19%)