DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Culd and Ldlr

DIOPT Version :9

Sequence 1:	NP_729364.1	Gene:	Culd / 38946	FlyBaseID:	FBgn0035880	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_786938.2	Gene:	Ldlr / 300438	RGDID:	2998	Length:	879	Species:	Rattus norvegicus

Alignment Length:	528	Identity:	112/528 - (21%)
Similarity:	164/528 - (31%)	Gaps:	176/528 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   443 EFLCGNNHCISIRLHCDGFDHCGDGSDE---------PDSCE-EDWAHLHHDRRWYSHKPNYYFP 497
            ||.||::.||.....|||...|.|.|||         ||..: .|.:.:|..|
  Rat   202 EFHCGSSECIHRSWVCDGAADCKDKSDEENCAVTTCRPDEFQCADGSCIHGSR------------ 254

  Fly   498 KIDQYPDLKTATGIFIISTLGIFGVL-----------SGWMVILYRMGVRARHQRELQSHLQTIS 551
            :.|:..|.|..:     ..||...|.           ||..:.|.::...||..|:...  :.|.
  Rat   255 QCDREHDCKDMS-----DELGCINVTQCDGPNKFKCHSGECISLDKVCNSARDCRDWSD--EPIK 312

  Fly   552 ELLDRQDEDRT-------PDEPPSYE--APPDYEEVIKVGMQ----QELREPR------------ 591
            |....:..|..       .|....||  .|..:..|  .|.|    .|.:||.
  Rat   313 ECKTNECLDNNGGCSHICKDLKIGYECLCPSGFRLV--DGHQCEDIDECQEPDTCSQLCVNLEGS 375

  Fly   592 ---RQRRARRAPPRDRSCSRAASNCTVQSVLPLH--RSCTLERDQEQPSTSAAAMTHAVAATDT- 650
               ..|......|..|.| :|..:.........|  |..||:|.:   .||.......|.|.||
  Rat   376 FKCECRAGFHMDPHTRVC-KAVGSIGFLLFTNRHEVRKMTLDRSE---YTSLIPNLKNVVALDTE 436

  Fly   651 -TEDAEHVQTMAQRMLLATAICGTAGTSLPAAKESGQRVQSVGISTSPSSLSA--GGELPTAGGS 712
             ..:..:...::||.:.:..:  ..||||                    |..|  .|:|....|.
  Rat   437 VANNRIYWSDLSQRKIYSAVM--DQGTSL--------------------SYDAIISGDLHAPDGL 479

  Fly   713 A------------TTPGSTADECTQGGDSLSISLTLG-LPSTTAESPV-----TTDQNQLQKQSP 759
            |            :.||:.:...|:|....::....| .|......||     .||.....|
  Rat   480 AVDWIHGNIYWTDSVPGTVSVADTKGVRRRTLFREKGSRPRAIVVDPVHGFMYWTDWGTPAK--- 541

  Fly   760 EQTISNCTEHTFLKRSWL------------------VVQQVPPGRGYRVRRLRHTFSS------- 799
                        :|:..|                  :...:|.||.|.|....|:.||
  Rat   542 ------------IKKGGLNGVDIYSLVTEDIQWPNGITLDLPSGRLYWVDSKLHSISSIDVNGGG 594

  Fly   800 PEAFTSDELHLPYPDFLS------YGTNLPHER-SSSN--FGSELSRDPSSYSVGKRARLTPEDT 855
            .:....||..|.:|..|:      |.|::.:|. .|:|  .||:::      .|.|.. ::|||.
  Rat   595 RKTILEDEKQLAHPFSLAIYEDKVYWTDVLNEAIFSANRLTGSDVN------LVAKNL-MSPEDI 652

  Fly   856 SGSETITQ 863
            .....:||
  Rat   653 VLFHNVTQ 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Culd	NP_729364.1	CUB	200..298	CDD:238001
Culd	NP_729364.1	LDLa	442..472	CDD:238060	14/37 (38%)
Ldlr	NP_786938.2	Ldl_recept_a	25..58	CDD:395011
		Ldl_recept_a	66..104	CDD:395011
		Ldl_recept_a	107..143	CDD:395011
		Ldl_recept_a	196..232	CDD:395011	14/29 (48%)
		Ldl_recept_a	235..271	CDD:395011	9/52 (17%)
		Ldl_recept_a	279..309	CDD:395011	6/31 (19%)
		FXa_inhibition	319..353	CDD:405372	7/35 (20%)
		EGF_CA	355..389	CDD:214542	4/33 (12%)
		LDL-receptor class B 1	398..439		11/43 (26%)
		NHL	<435..628	CDD:302697	42/229 (18%)
		NHL repeat	435..469	CDD:271320	9/55 (16%)
		LDL-receptor class B 2	440..485		12/66 (18%)
		NHL repeat	476..514	CDD:271320	6/37 (16%)
		LDL-receptor class B 3	486..528		7/41 (17%)
		LDL-receptor class B 4	529..572		5/57 (9%)
		Ldl_recept_b	529..569	CDD:395012	5/54 (9%)
		NHL repeat	555..600	CDD:271320	8/44 (18%)
		LDL-receptor class B 5	573..615		12/41 (29%)
		NHL repeat	606..628	CDD:271320	5/21 (24%)
		LDL-receptor class B 6	616..658		12/48 (25%)
		Ldl_recept_b	616..655	CDD:395012	12/45 (27%)
		FXa_inhibition	674..711	CDD:405372
		Clustered O-linked oligosaccharides	717..788
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	718..797
		Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000250\|UniProtKB:P01130	830..879
		NPXY motif. /evidence=ECO:0000250\|UniProtKB:P01130	842..847
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900