DRSC/TRiP Functional Genomics Resources

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Protein Alignment Culd and Ldlr

DIOPT Version :10

Sequence 1:NP_729364.1 Gene:Culd / 38946 FlyBaseID:FBgn0035880 Length:965 Species:Drosophila melanogaster
Sequence 2:NP_786938.2 Gene:Ldlr / 300438 RGDID:2998 Length:879 Species:Rattus norvegicus


Alignment Length:528 Identity:112/528 - (21%)
Similarity:164/528 - (31%) Gaps:176/528 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   443 EFLCGNNHCISIRLHCDGFDHCGDGSDE---------PDSCE-EDWAHLHHDRRWYSHKPNYYFP 497
            ||.||::.||.....|||...|.|.|||         ||..: .|.:.:|..|            
  Rat   202 EFHCGSSECIHRSWVCDGAADCKDKSDEENCAVTTCRPDEFQCADGSCIHGSR------------ 254

  Fly   498 KIDQYPDLKTATGIFIISTLGIFGVL-----------SGWMVILYRMGVRARHQRELQSHLQTIS 551
            :.|:..|.|..:     ..||...|.           ||..:.|.::...||..|:...  :.|.
  Rat   255 QCDREHDCKDMS-----DELGCINVTQCDGPNKFKCHSGECISLDKVCNSARDCRDWSD--EPIK 312

  Fly   552 ELLDRQDEDRT-------PDEPPSYE--APPDYEEVIKVGMQ----QELREPR------------ 591
            |....:..|..       .|....||  .|..:..|  .|.|    .|.:||.            
  Rat   313 ECKTNECLDNNGGCSHICKDLKIGYECLCPSGFRLV--DGHQCEDIDECQEPDTCSQLCVNLEGS 375

  Fly   592 ---RQRRARRAPPRDRSCSRAASNCTVQSVLPLH--RSCTLERDQEQPSTSAAAMTHAVAATDT- 650
               ..|......|..|.| :|..:.........|  |..||:|.:   .||.......|.|.|| 
  Rat   376 FKCECRAGFHMDPHTRVC-KAVGSIGFLLFTNRHEVRKMTLDRSE---YTSLIPNLKNVVALDTE 436

  Fly   651 -TEDAEHVQTMAQRMLLATAICGTAGTSLPAAKESGQRVQSVGISTSPSSLSA--GGELPTAGGS 712
             ..:..:...::||.:.:..:  ..||||                    |..|  .|:|....|.
  Rat   437 VANNRIYWSDLSQRKIYSAVM--DQGTSL--------------------SYDAIISGDLHAPDGL 479

  Fly   713 A------------TTPGSTADECTQGGDSLSISLTLG-LPSTTAESPV-----TTDQNQLQKQSP 759
            |            :.||:.:...|:|....::....| .|......||     .||.....|   
  Rat   480 AVDWIHGNIYWTDSVPGTVSVADTKGVRRRTLFREKGSRPRAIVVDPVHGFMYWTDWGTPAK--- 541

  Fly   760 EQTISNCTEHTFLKRSWL------------------VVQQVPPGRGYRVRRLRHTFSS------- 799
                        :|:..|                  :...:|.||.|.|....|:.||       
  Rat   542 ------------IKKGGLNGVDIYSLVTEDIQWPNGITLDLPSGRLYWVDSKLHSISSIDVNGGG 594

  Fly   800 PEAFTSDELHLPYPDFLS------YGTNLPHER-SSSN--FGSELSRDPSSYSVGKRARLTPEDT 855
            .:....||..|.:|..|:      |.|::.:|. .|:|  .||:::      .|.|.. ::|||.
  Rat   595 RKTILEDEKQLAHPFSLAIYEDKVYWTDVLNEAIFSANRLTGSDVN------LVAKNL-MSPEDI 652

  Fly   856 SGSETITQ 863
            .....:||
  Rat   653 VLFHNVTQ 660

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CuldNP_729364.1 CUB 200..298 CDD:238001
LDLa 442..472 CDD:238060 14/37 (38%)
LdlrNP_786938.2 Ldl_recept_a 25..58 CDD:395011
Ldl_recept_a 66..104 CDD:395011
Ldl_recept_a 107..143 CDD:395011
Ldl_recept_a 196..232 CDD:395011 14/29 (48%)
Ldl_recept_a 235..271 CDD:395011 9/52 (17%)
Ldl_recept_a 279..309 CDD:395011 6/31 (19%)
FXa_inhibition 319..353 CDD:464251 7/35 (20%)
EGF_CA 355..389 CDD:214542 4/33 (12%)
LDL-receptor class B 1 398..439 11/43 (26%)
NHL <435..628 CDD:302697 42/229 (18%)
NHL repeat 435..469 CDD:271320 9/55 (16%)
LDL-receptor class B 2 440..485 12/66 (18%)
NHL repeat 476..514 CDD:271320 6/37 (16%)
LDL-receptor class B 3 486..528 7/41 (17%)
LDL-receptor class B 4 529..572 5/57 (9%)
Ldl_recept_b 529..569 CDD:459654 5/54 (9%)
NHL repeat 555..600 CDD:271320 8/44 (18%)
LDL-receptor class B 5 573..615 12/41 (29%)
NHL repeat 606..628 CDD:271320 5/21 (24%)
LDL-receptor class B 6 616..658 12/48 (25%)
Ldl_recept_b 616..656 CDD:459654 12/46 (26%)
FXa_inhibition 674..711 CDD:464251
Clustered O-linked oligosaccharides 717..788
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 718..797
Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000250|UniProtKB:P01130 830..879
NPXY motif. /evidence=ECO:0000250|UniProtKB:P01130 842..847
Blue background indicates that the domain is not in the aligned region.

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