DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Culd and Lrp1

DIOPT Version :9

Sequence 1:NP_729364.1 Gene:Culd / 38946 FlyBaseID:FBgn0035880 Length:965 Species:Drosophila melanogaster
Sequence 2:XP_008763615.1 Gene:Lrp1 / 299858 RGDID:1307535 Length:4562 Species:Rattus norvegicus


Alignment Length:910 Identity:173/910 - (19%)
Similarity:275/910 - (30%) Gaps:315/910 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 HWDGRRHFLELGSPAGEVHARNVTTTAYRSSPL------------VFKNDAVAGDVWYQCSLELV 92
            :|..|.|       |.....|.....|..|.||            ||..|...|.  ..|::...
  Rat  2127 YWSDRTH-------ANGSIKRGCKDNATDSVPLRTGIGVQLKDIKVFNRDRQKGT--NVCAVANG 2182

  Fly    93 TCAE-CVIRVAFTYANFSKSCGNTGGKSSMCPCEHIQFSEPPYDSTISGQEFCG-----DGKVFR 151
            .|.: |:.|               ||....|.|.|...:|    ...|.:|:.|     :..:.:
  Rat  2183 GCQQLCLYR---------------GGGQRACACAHGMLAE----DGASCREYAGYLLYSERTILK 2228

  Fly   152 S---------------------KTRTLQLKFFYRA------------SNAHVFSLQYFSERNVRI 183
            |                     ....:.|.|.|||            |:.|..::|..::     
  Rat  2229 SIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQIND----- 2288

  Fly   184 VSGSPKQSIVGN----------------------GSTKSQPQVISTPYFPMAYPRD-----YGIE 221
             .||.:.:||.|                      .||.::..|..|.  |.|:.|:     .|.:
  Rat  2289 -DGSGRTTIVENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTR--PGAFERETVITMSGDD 2350

  Fly   222 HILTCEADNCQVRLDFTDFQLGLTSTLEIFDSNGQMLDSYTGEHFRPPI--TVSSGKSLLL---- 280
            |......|.||..:.:|::                       ....|.|  ...||.::|.    
  Rat  2351 HPRAFVLDECQNLMFWTNW-----------------------NELHPSIMRAALSGANVLTLIEK 2392

  Fly   281 QFRGNSATGVGFRAEVSFVSSKQ-----------------LKDERLVPYTDCGGMVTGPGGAITM 328
            ..|..:...:..|||..:.|...                 ||.|.:.|:   |..|.|.      
  Rat  2393 DIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPF---GLAVYGE------ 2448

  Fly   329 MNMIENATDVRLFDCIWI---IKPGNNYMMMKTHISLRVDDFYGMAARSELTIRQGTTSDAVEIE 390
                      .:|...|:   ::..|.|:.....: ||||    :..:....|.....:::.|:.
  Rat  2449 ----------HIFWTDWVRRAVQRANKYVGSDMKL-LRVD----IPQQPMGIIAVANDTNSCELS 2498

  Fly   391 NVMWPNNG------LSKESHVAPILNGYYIRLRGVF---GMSSKLAIVYSVFNYLNCYIGSEFLC 446
            .....|.|      |:.:.||.....|..| |:..|   .|:|            :|....||.|
  Rat  2499 PCRINNGGCQDLCLLTHQGHVNCSCRGGRI-LQEDFTCRAMNS------------SCRAQDEFEC 2550

  Fly   447 GNNHCISIRLHCDGFDHCGDGSDEPDS------CEEDWAHLHHDR-----RWYSHKPNYYFPKID 500
            .|..|||..|.|||..||.|.|||..|      |::.:...::.|     .|.:...: .....|
  Rat  2551 ANGECISFSLTCDGVSHCKDKSDEKPSYCNSRRCKKTFRQCNNGRCVSNMLWCNGVDD-CGDGSD 2614

  Fly   501 QYPDLKTATGIFIISTLGIFGVLSGWMVILYRMGVRARHQRELQSHLQTISELLDRQDEDRTPDE 565
            :.|..|||.|:      |.|....|..:     |..:|           .::.:|.:|   ..||
  Rat  2615 EIPCNKTACGV------GEFRCRDGSCI-----GNSSR-----------CNQFVDCED---ASDE 2654

  Fly   566 PPSYEAPPDYEEVIKVGMQQELREPRRQRRARRAP-------------PRDRSC-----SRAASN 612
            ...  :..|.....::|::..|.:|..:.....||             ..:|.|     .|...|
  Rat  2655 MNC--SATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLN 2717

  Fly   613 ---CTVQSVLPLHRSCTLERDQEQPSTSAAAMTHA-VAATDTTEDAEHVQTMAQRMLL-ATAICG 672
               |.....:|:..:|    |:|....:....||. ...::...:.::.:.::::.|. .:..||
  Rat  2718 YFACPSGRCIPMSWTC----DKEDDCENGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCG 2778

  Fly   673 TAGTSLPAAKESGQRVQSVGISTSPSSLSAGGELPTAGGSATTPGSTADECTQGGDSLSISLTLG 737
            ..         |.:.....|.:..|||.|..|............|.  .:|..|.|.   |::.|
  Rat  2779 DG---------SDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGD--KDCADGADE---SISAG 2829

  Fly   738 -LPSTTAESPVTTDQNQL-----------------QKQSPEQTISNCTEHTF--------LKRSW 776
             |.::|.:......||:|                 ..:|||.....|..:.|        ..|.|
  Rat  2830 CLYNSTCDDREFMCQNRLCIPKHFVCDHDRDCADGSDESPECEYPTCGPNEFRCANGRCLSSRQW 2894

  Fly   777  776
              Rat  2895  2894

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CuldNP_729364.1 CUB 200..298 CDD:238001 20/108 (19%)
LDLa 442..472 CDD:238060 17/29 (59%)
Lrp1XP_008763615.1 LDLa 27..60 CDD:197566
LDLa 72..105 CDD:197566
FXa_inhibition 120..149 CDD:291342
FXa_inhibition 161..189 CDD:291342
LY 276..315 CDD:214531
LY 317..359 CDD:214531
LY 362..402 CDD:214531
FXa_inhibition 487..520 CDD:291342
LY 552..594 CDD:214531
LY 595..634 CDD:214531
LY 641..690 CDD:214531
LY <701..734 CDD:214531
FXa_inhibition 808..843 CDD:291342
LDLa 854..886 CDD:197566
LDLa 896..929 CDD:238060
LDLa 936..968 CDD:197566
LDLa 979..1012 CDD:238060
LDLa 1033..1066 CDD:238060
LDLa 1080..1115 CDD:238060
LDLa 1122..1158 CDD:238060
LDLa 1163..1196 CDD:238060
FXa_inhibition 1203..1239 CDD:291342
LY 1354..1394 CDD:214531
LY 1398..1441 CDD:214531
LY 1442..1486 CDD:214531
LY 1631..1667 CDD:214531
LY 1668..1711 CDD:214531
LY 1715..1752 CDD:214531
LY 1752..1793 CDD:214531
FXa_inhibition 1868..1904 CDD:291342
LY 1934..1974 CDD:214531
LY 1977..2017 CDD:214531
LY 2018..2061 CDD:214531
LY 2063..2105 CDD:214531
FXa_inhibition 2177..2212 CDD:291342 10/53 (19%)
YvrE 2271..2481 CDD:225921 46/264 (17%)
Ldl_recept_b 2362..2403 CDD:278487 7/63 (11%)
LY 2388..2429 CDD:214531 5/40 (13%)
FXa_inhibition 2500..2532 CDD:291342 8/32 (25%)
LDLa 2545..2575 CDD:238060 16/29 (55%)
LDLa 2584..2618 CDD:238060 4/34 (12%)
LDLa 2623..2657 CDD:238060 10/58 (17%)
LDLa <2684..2706 CDD:238060 3/21 (14%)
LDLa 2714..2748 CDD:238060 7/37 (19%)
LDLa 2752..2783 CDD:197566 4/39 (10%)
LDLa 2791..2824 CDD:197566 8/34 (24%)
LDLa 2835..2867 CDD:197566 4/31 (13%)
LDLa 2875..2908 CDD:197566 4/20 (20%)
LDLa 2925..2957 CDD:238060
cEGF 2980..3003 CDD:289433
EGF_CA 3000..>3029 CDD:214542
LY 3067..3111 CDD:214531
LY 3112..3154 CDD:214531
LY 3156..3198 CDD:214531
LY 3200..3241 CDD:214531
LY 3242..3282 CDD:214531
FXa_inhibition 3312..3348 CDD:291342
LDLa 3352..3383 CDD:238060
LDLa 3392..3426 CDD:238060
LDLa 3431..3466 CDD:238060
LDLa 3470..3503 CDD:197566
LDLa 3511..3544 CDD:197566
LDLa 3554..3588 CDD:238060
LDLa 3593..3627 CDD:238060
LDLa 3631..3665 CDD:238060
LDLa 3671..3703 CDD:197566
LDLa 3713..3749 CDD:238060
LDLa 3764..3794 CDD:238060
LY 3973..4010 CDD:214531
Ldl_recept_b 4031..4071 CDD:278487
LY 4055..4096 CDD:214531
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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