DRSC/TRiP Functional Genomics Resources

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Protein Alignment Culd and LRP12

DIOPT Version :9

Sequence 1:NP_729364.1 Gene:Culd / 38946 FlyBaseID:FBgn0035880 Length:965 Species:Drosophila melanogaster
Sequence 2:NP_038465.1 Gene:LRP12 / 29967 HGNCID:31708 Length:859 Species:Homo sapiens


Alignment Length:896 Identity:181/896 - (20%)
Similarity:275/896 - (30%) Gaps:350/896 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 WPGEAYPASSSYRDLDICNHWDGRRHFLELGSPAGEVHARNVTTTAYRSSPLVFKNDAVAGDVWY 85
            ||.| |||..:      |: |..|.:       .||:    :|        :.|::..:.|.  .
Human    66 WPSE-YPAKIN------CS-WFIRAN-------PGEI----IT--------ISFQDFDIQGS--R 101

  Fly    86 QCSLELVTCAECVIRVAFTYANFS--KSCGNTGGKSSMCPCEHIQFSEPPYDSTISGQE-----F 143
            :|:|:.:|..        ||.|..  ::||:|              ..|||   ||.|:     |
Human   102 RCNLDWLTIE--------TYKNIESYRACGST--------------IPPPY---ISSQDHIWIRF 141

  Fly   144 CGDGKVFRSKTRTLQLKFFYRASNAHVFSLQYFSERNVRIVSGSPK----QSIVGNGS------- 197
            ..|..:.|..                 |.|.|||.:     |..|.    |...|||.       
Human   142 HSDDNISRKG-----------------FRLAYFSGK-----SEEPNCACDQFRCGNGKCIPEAWK 184

  Fly   198 ----------------TKSQPQVISTPYFPMAYPRDYGIEH---ILTC--EADNCQVRLDFTDFQ 241
                            .|......:..:.|.||.:...:..   :.||  |:..|...:|..|  
Human   185 CNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLD-- 247

  Fly   242 LGLTSTLEIFDSNGQMLDSYTG-------EHFRPP-------ITVSSGKSLLLQFRGNSATGVGF 292
            ||.....:: .:.||.|..:.|       ..|.||       |.....:.::|:|......|.|:
Human   248 LGDEIDCDV-PTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGY 311

  Fly   293 RAEVSFVSSKQLKDERLV----------PYTDCGGMVTGPGGAITMMNMIENATDVRLFD----- 342
            ...|......:....:|:          |.|     |....|.|.:....:.....|.|:     
Human   312 GDYVKIYDGLEENPHKLLRVLTAFDSHAPLT-----VVSSSGQIRVHFCADKVNAARGFNATYQV 371

  Fly   343 ---CI-WIIKPGNNYMMMKTHISLRVDDFY-----------GMAARSELTI-RQGT---TSDAVE 388
               |: |.|..|.|:.....  ..|.|.::           .|..:.|... |.|.   .||...
Human   372 DGFCLPWEIPCGGNWGCYTE--QQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCN 434

  Fly   389 IENVMWPNNGLSKESHVAPILNGYYIRLRGVFGMSSKLAIVYSVFNYLNCYI--GSEFLCGNNHC 451
            .:| ..||....|                                   ||:.  ...|.|.||.|
Human   435 YQN-HCPNGSDEK-----------------------------------NCFFCQPGNFHCKNNRC 463

  Fly   452 ISIRLHCDGFDHCGDGSDEPDSCEEDWAHLHHDRRWYSHKPNYYFPKIDQYPDLKTATGIFIIST 516
            :.....||..|.||||||| ::|                      |.|       ..|.:...:.
Human   464 VFESWVCDSQDDCGDGSDE-ENC----------------------PVI-------VPTRVITAAV 498

  Fly   517 LG--IFGVLSGWMVI-------LYRMGVRARHQRELQSHLQTI-SELLDRQDEDRTPDEPPSYEA 571
            :|  |.|:|   :||       ||  .:|...:|..::.|..: :|||.|             ||
Human   499 IGSLICGLL---LVIALGCTCKLY--SLRMFERRSFETQLSRVEAELLRR-------------EA 545

  Fly   572 PPDYEEVIKVGM-----------------QQELREPRRQR---RARRAPPRDRSC---------- 606
            ||.|.::|..|:                 .:.||...|.:   .:.|.|...||.          
Human   546 PPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSVRLPMAGRSSNIWNRIFNFA 610

  Fly   607 -SRAASNCTVQS-----VLPLHRSCTLERDQEQPSTSAAAMTHAVAATDTTEDAEHV-------- 657
             ||.:.:..:.|     |:|   |.:..|:.|:..|..:..:.....|||..:...:        
Human   611 RSRHSGSLALVSADGDEVVP---SQSTSREPERNHTHRSLFSVESDDTDTENERRDMAGASGGVA 672

  Fly   658 QTMAQRMLLATAICGTAGTSLPAAKES--------GQRVQSVGISTSPSSLSAGGELPTAGGSAT 714
            ..:.|::...||:..|.|....::.:|        |:.|.||    .|.|:|......|:..|..
Human   673 APLPQKVPPTTAVEATVGACASSSTQSTRGGHADNGRDVTSV----EPPSVSPARHQLTSALSRM 733

  Fly   715 TPGSTADECTQGGDSLSISLTLGLPSTTAESPVTTDQNQLQKQSPEQTISN 765
            |.|..           .:..|||..|:.:           |.|||.:.:.|
Human   734 TQGLR-----------WVRFTLGRSSSLS-----------QNQSPLRQLDN 762

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CuldNP_729364.1 CUB 200..298 CDD:238001 24/116 (21%)
LDLa 442..472 CDD:238060 15/29 (52%)
LRP12NP_038465.1 CUB 47..158 CDD:238001 35/162 (22%)
LDLa 166..200 CDD:238060 4/33 (12%)
LDLa 215..254 CDD:238060 10/40 (25%)
CUB 267..371 CDD:238001 18/108 (17%)
LDLa 375..410 CDD:238060 7/36 (19%)
LDLa 413..448 CDD:238060 9/70 (13%)
LDLa 451..485 CDD:238060 15/34 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 623..678 9/57 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 693..723 8/33 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 748..770 6/26 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 801..823
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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