DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Culd and Lrp5

DIOPT Version :9

Sequence 1:NP_729364.1 Gene:Culd / 38946 FlyBaseID:FBgn0035880 Length:965 Species:Drosophila melanogaster
Sequence 2:NP_001099791.2 Gene:Lrp5 / 293649 RGDID:1309329 Length:1600 Species:Rattus norvegicus


Alignment Length:538 Identity:111/538 - (20%)
Similarity:166/538 - (30%) Gaps:188/538 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   110 KSCGNTGGKSSM--CPCEHIQFSEPPYD-----------------STISGQEFCGD--GKVF--- 150
            |...:.|.:.||  .|.:.:.....|:|                 :||:.....||  |.|.   
  Rat  1001 KRAKDDGTQPSMLTSPSQSLSPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLDGDAMGVVLRGD 1065

  Fly   151 RSKTRTLQLK-----FFYRASNAHVFSLQYFS----ERNVRIVSG--SPKQSIVGNGSTKSQPQV 204
            |.:.|.:.:.     .::.....|...::..|    ||.|...:|  .|...:|.|...|     
  Rat  1066 RDRPRAIAVNAERGYMYFTNMQDHAAKIERASLDGTEREVLFTTGLIRPVALVVDNALGK----- 1125

  Fly   205 ISTPYFPMAYPRDYGIEHILTCEADNCQVRLDFTDFQL----GLT---STLEIFDSNGQML---D 259
                    .:..|..::.|.:|:..... ||...|..:    |||   ..|...|...||:   :
  Rat  1126 --------LFWVDADLKRIESCDLSGAN-RLTLEDANIVQPVGLTVLGRHLYWIDRQQQMIERVE 1181

  Fly   260 SYTGEHFRPPITVSSGKSLLLQFRGNSATGVGFRAEVSFVSSKQLKDERLVPYT-DCGG-----M 318
            ..||:           |...:|.|....||:....|||      |::....|.. |.||     :
  Rat  1182 KTTGD-----------KRTRVQGRVTHLTGIHAVEEVS------LEEFSAHPCARDNGGCSHICI 1229

  Fly   319 VTGPG--------GAITMMNMI-----------ENATDVRLFDCIWIIKPGNNYMMMKTHISLRV 364
            ..|.|        ..:.:.|::           :.|......|||    ||          :.|.
  Rat  1230 AKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCI----PG----------AWRC 1280

  Fly   365 DDFYGMAARSELTIRQGTTSDAVEIENVMWPNNGLSKESHVAPILNGYYIRLRGVFGMSSKLAIV 429
            |.|...|.:|:   .:|.            |....|:    .|...|..:.||            
  Rat  1281 DGFPECADQSD---EEGC------------PVCSASQ----FPCARGQCVDLR------------ 1314

  Fly   430 YSVFNYLNC---YIGSEFLCGNNHCISIRLHCDGFDHCGDGSDEPDSCEEDWAHLHHDRRWYSHK 491
                  |.|   .:.::|.|.:..|:.|:..||.|..|.|||||. .||.:              
  Rat  1315 ------LRCDAVCLPNQFRCASGQCVLIKQQCDSFPDCADGSDEL-MCEIN-------------- 1358

  Fly   492 PNYYFPKIDQYPDLKTATG--IFIISTLGIFGVLSGWMVILYRMGVRARHQRELQSHLQTISELL 554
                .|..|..|...:|.|  |.||.:|.:.|            ||....||.:.......|...
  Rat  1359 ----KPPSDDVPAHSSAIGPVIGIILSLFVMG------------GVYFVCQRVMCQRYTGASGPF 1407

  Fly   555 DRQDEDRTPDEPPSYEAP 572
            ..:....||..|.::.||
  Rat  1408 PHEYVGGTPHVPLNFIAP 1425

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CuldNP_729364.1 CUB 200..298 CDD:238001 22/107 (21%)
LDLa 442..472 CDD:238060 13/29 (45%)
Lrp5NP_001099791.2 NHL <37..>169 CDD:302697
NHL repeat 65..104 CDD:271320
LY 102..142 CDD:214531
NHL repeat 107..148 CDD:271320
Ldl_recept_b 163..203 CDD:278487
LY 187..229 CDD:214531
LY 230..271 CDD:214531
FXa_inhibition 299..336 CDD:291342
LY 366..406 CDD:214531
LY 408..450 CDD:214531
LY 451..494 CDD:214531
LY 495..537 CDD:214531
LY 538..571 CDD:214531
FXa_inhibition 605..640 CDD:291342
NHL 685..878 CDD:302697
LY 710..752 CDD:214531
NHL repeat 720..756 CDD:271320
NHL repeat 763..802 CDD:271320
NHL repeat 808..843 CDD:271320
NHL repeat 847..871 CDD:271320
FXa_inhibition 906..941 CDD:291342
LY 1060..1103 CDD:214531 5/42 (12%)
LY 1104..1146 CDD:214531 9/55 (16%)
FXa_inhibition 1217..1253 CDD:291342 6/35 (17%)
LDLa 1259..1295 CDD:238060 11/52 (21%)
LDLa 1321..1355 CDD:238060 13/34 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.