DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Culd and LpR1

DIOPT Version :9

Sequence 1:	NP_729364.1	Gene:	Culd / 38946	FlyBaseID:	FBgn0035880	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_001097934.2	Gene:	LpR1 / 2768687	FlyBaseID:	FBgn0066101	Length:	1076	Species:	Drosophila melanogaster

Alignment Length:	740	Identity:	127/740 - (17%)
Similarity:	196/740 - (26%)	Gaps:	308/740 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 SPAGEVHARNVTTTAYRSSPLVFKN--DAVAGDVWYQCSLELVTCAECVIRVAFTYANFSKSCGN 114
            |.|.|.....:.:|....||:.|.|  :....:..::|:     ||...:.:......|.|.|..
  Fly     9 STASETTKTAIKSTTSSKSPVTFGNLGEKRRAEQLFRCA-----CANFNLLLLTLMLGFGKCCTA 68

  Fly   115 T----GGKSSMCPCEHIQFSEPPYDSTISGQEFCGDGKVFRSKTRTLQLKFFYRASNAHVFSLQY 175
            |    ...|:..|...:....|.............|||.|.:    :..||.
  Fly    69 TPTPLNTPSTNTPTSAVSPHNPQTLDESGSLSKVIDGKAFIN----MGFKFL------------- 116

  Fly   176 FSERNVRIVSGSPKQSIVGNGST------KSQPQVISTPYFPMAYPRDYGIEHILTCEAD-NCQV 233
                ||....|:|    :|.|.:      :.|.|..|....|:.:          .|:.| :|:
  Fly   117 ----NVSGKIGTP----LGIGQSLEAKCDEKQFQCHSGDCIPIRF----------VCDGDADCK- 162

  Fly   234 RLDFTDFQLGLTSTLEIFDSNGQMLDSYTGEHFRPPITVSSGKSLLLQFR-GNSATGVGFRAEVS 297
              |.:|.|:.....:|                    .|.||.     ||| ||.          :
  Fly   163 --DHSDEQIKECKFIE--------------------ATCSSD-----QFRCGNG----------N 190

  Fly   298 FVSSKQLKDERLVPYTDCGGMVTGPGGAITMMNMIENATDVRLFDC---------IWIIKPGNNY 353
            .:.:|...|:.    :||.      .|:.....:..||.....|.|         .|:. .|:|.
  Fly   191 CIPNKWRCDQE----SDCA------DGSDEANELCMNACPNNEFKCQTVDQCIPRSWLC-DGSND 244

  Fly   354 MMMKTHISLRVDDFYGMAARSELTIRQGTTSDAVEIENVMWPNNGLSKESHVAPILNGYYIRLRG 418
            ...|:               .|...|..|.|          |:....|..      .|..:.|..
  Fly   245 CRDKS---------------DEAHCRARTCS----------PDEYACKSG------EGQCVPLAW 278

  Fly   419 VFGMSSKLAIVYSVFNYLNCYIGS------------EFLCGNNHCISIRLHCDGFDHCGDGSDEP 471
            :...|.            :|..||            ||.|||..||..|..||..|.|||||||.
  Fly   279 MCDQSK------------DCSDGSDEHNCNQTCRADEFTCGNGRCIQKRWKCDHDDDCGDGSDEK 331

  Fly   472 D----SCEEDWAHLHHD-----RRWYSHKPNYYFPKIDQYPDLKTATGIFIISTLGIFGVLSGWM 527
            :    .|:....|...:     :||.          .|..||....:
  Fly   332 ECPVVPCDSVAEHTCTNGACIAKRWV----------CDGDPDCSDGS------------------ 368

  Fly   528 VILYRMGVRARHQRELQSHLQTISELLDRQ----------------DEDRTPDEPPSYEAPPDYE 576
                       .:|...:..:|.:..|..:                |.||        :.|...:
  Fly   369 -----------DERSCANVTKTTTPCLSHEYQCKDRITCLHHSWLCDGDR--------DCPDGDD 414

  Fly   577 EVIKVGMQQELREPRRQRRARRAPPRDRSCSRAASNCTVQSVLPLHRSCTLERDQEQPSTSAAAM 641
            |                   ..|..::.:|......|..:|.:|.|.:|..::|
  Fly   415 E-------------------HTANCKNVTCRADQFQCGDRSCIPGHLTCNGDKD----------- 449

  Fly   642 THAVAATDTTEDAEHVQTMAQRMLLATAICGTAGTSLPAAKESGQRVQSVGISTSPSSLSAGGEL 706
                 ..|.:::.:               ||.                |:.:..:....:|..|.
  Fly   450 -----CADGSDERD---------------CGL----------------SLSLGINQGGCNATSEF 478

  Fly   707 PTAGGSATTPGSTAD---ECTQGGD 728
            ...||.........|   :|..|.|
  Fly   479 DCGGGQCVPLSKVCDKRKDCPDGED 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Culd	NP_729364.1	CUB	200..298	CDD:238001	19/99 (19%)
Culd	NP_729364.1	LDLa	442..472	CDD:238060	19/41 (46%)
LpR1	NP_001097934.2	LDLa	135..167	CDD:197566	8/44 (18%)
		LDLa	178..210	CDD:197566	13/56 (23%)
		LDLa	219..254	CDD:238060	7/50 (14%)
		LDLa	259..295	CDD:238060	9/63 (14%)
		LDLa	343..373	CDD:238060	7/68 (10%)
		LDLa	383..415	CDD:197566	5/39 (13%)
		Ldl_recept_a	423..459	CDD:278486	8/66 (12%)
		LDLa	476..504	CDD:197566	7/28 (25%)
		FXa_inhibition	514..549	CDD:291342
		EGF_CA	551..581	CDD:214542
		LY	662..702	CDD:214531
		LY	704..747	CDD:214531
		LY	749..790	CDD:214531
		FXa_inhibition	864..905	CDD:291342
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24270
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100