DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Culd and LRP10

DIOPT Version :9

Sequence 1:	NP_729364.1	Gene:	Culd / 38946	FlyBaseID:	FBgn0035880	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	XP_005267567.1	Gene:	LRP10 / 26020	HGNCID:	14553	Length:	721	Species:	Homo sapiens

Alignment Length:	779	Identity:	151/779 - (19%)
Similarity:	223/779 - (28%)	Gaps:	318/779 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 PAGEVHARNVTTT----------------AYRSSPLVFKNDAVAGDVWYQCSLELVTCA--ECVI 99
            |.|     |||.|                :|..:||    ...:.| |..|..|...|.  .||
Human   108 PGG-----NVTITYSYAGARAPMGQGFLLSYSQAPL----HGASAD-WLMCLQEEFQCLNHRCV- 161

  Fly   100 RVAFTYANFSKSCGNTGGKSSMCPCEHIQFSEPPYDSTISGQEFCGDGKVFRSKTRTLQLKFFYR 164
                               |::..|:              |.:.||||
Human   162 -------------------SAVQRCD--------------GVDACGDG----------------- 176

  Fly   165 ASNAHVFSLQYFSERNVRIVSGSPKQSIVGNGSTKSQPQVISTPYFPMAYPRDYGIEHILTCE-- 227
             |:....|...|.....|     |..|:..|.:.:....|.|:|    .|.....:.|..:|.
Human   177 -SDEAGCSSDPFPGLTPR-----PVPSLPCNVTLEDFYGVFSSP----GYTHLASVSHPQSCHWL 231

  Fly   228 ---ADNCQVRLDFTDFQLGLTSTLEIFDSNG-----QMLDSYTGEHFRPPITVSSGKSLLLQFRG 284
               .|..::.:.||...||....:.::|..|     ::|.|.|  ||      |:||::.::...
Human   232 LDPHDGRRLAVRFTALDLGFGDAVHVYDGPGPPESSRLLRSLT--HF------SNGKAVTVETLS 288

  Fly   285 NSA----------TGVGFRAEVSFVSSKQLKDERLVPYTDCG---GMVTGPGGAITMMNMIENAT 336
            ..|          .|.||.| ...|....|..:|     .||   |:..|.|
Human   289 GQAVVSYHTVAWSNGRGFNA-TYHVRGYCLPWDR-----PCGLGSGLGAGEG------------- 334

  Fly   337 DVRLFDCIWIIKPGNNYMMMKTHISLRVDDFYGMAARSELTIRQGTTSDAVEIENVMWPNNGLSK 401
                                           .|....||.....|:           |.....:.
Human   335 -------------------------------LGERCYSEAQRCDGS-----------WDCADGTD 357

  Fly   402 ESHVAPILNGYYIRLRGVFGMSSKLAIV-------YSVFNYLNCYIGSE-----------FLCGN 448
            |........|::  ..|..|.|...|..       |..|    |..|::           |.|.:
Human   358 EEDCPGCPPGHF--PCGAAGTSGATACYLPADRCNYQTF----CADGADERRCRHCQPGNFRCRD 416

  Fly   449 NHCISIRLHCDGFDHCGDGSDEPDSCEEDWAHLHHDRRWYSHKPNYYFPKIDQYPDLKTATGIFI 513
            ..|:.....|||...|.|||||.| |                  :|..|:              .
Human   417 EKCVYETWVCDGQPDCADGSDEWD-C------------------SYVLPR--------------K 448

  Fly   514 ISTLGIFGVLSGWMVILYRMGVRARHQRELQSHLQTISELLDRQDEDRTPDEPPSYEAPPDYEEV 578
            :.|..:.|.|...::::..:|...: ...:::...:|...|.|.:.     |....:|||.|.::
Human   449 VITAAVIGSLVCGLLLVIALGCTCK-LYAIRTQEYSIFAPLSRMEA-----EIVQQQAPPSYGQL 507

  Fly   579 IKVG------------------------MQQELREP----------RRQ---------RRARR-- 598
            |..|                        :.|.||:.          |||         ||.||
Human   508 IAQGAIPPVEDFPTENPNDNSVLGNLRSLLQILRQDMTPGGGPGARRRQRGRLMRRLVRRLRRWG 572

  Fly   599 APPRDRSCSRA--ASNCTVQSVLPLHRSCTLERDQEQPSTSAAAMTHAVAATDTTEDAEHVQTMA 661
            ..||..:.:||  |.:....|..||        :.....|..|....||..    :|.|....:.
Human   573 LLPRTNTPARASEARSQVTPSAAPL--------EALDGGTGPAREGGAVGG----QDGEQAPPLP 625

  Fly   662 QRMLLATAICGTAGTSLPAAKESGQRVQSVGISTSPSSLSA------GGELPTAGGSATTPGST 719
            .:..|.:|....|.|::|   |:...:.|:.:  .||.||.      |..||:.|    .||.|
Human   626 IKAPLPSASTSPAPTTVP---EAPGPLPSLPL--EPSLLSGVVQALRGRLLPSLG----PPGPT 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Culd	NP_729364.1	CUB	200..298	CDD:238001	26/117 (22%)
Culd	NP_729364.1	LDLa	442..472	CDD:238060	12/40 (30%)
LRP10	XP_005267567.1	CUB	34..134	CDD:238001	6/30 (20%)
		LDLa	148..182	CDD:238060	13/85 (15%)
		CUB	200..310	CDD:238001	27/122 (22%)
		LDLa	<338..361	CDD:238060	5/33 (15%)
		LDLa	407..441	CDD:238060	13/34 (38%)
		PRK04654	<581..683	CDD:135173	30/121 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900