DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Culd and Neto1

DIOPT Version :9

Sequence 1:	NP_729364.1	Gene:	Culd / 38946	FlyBaseID:	FBgn0035880	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_659195.3	Gene:	Neto1 / 246317	MGIID:	2180216	Length:	533	Species:	Mus musculus

Alignment Length:	556	Identity:	115/556 - (20%)
Similarity:	198/556 - (35%)	Gaps:	171/556 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 RIVSGSPKQSIVGNGSTKSQPQVISTPYFPMAYPRD----------------------YGIEHIL 224
            :|...:.|....|..:..::..|.::|.:|..||.|                      |.||...
Mouse    30 QITPETQKSVQCGTWTKHAEGGVFTSPNYPSKYPPDRECVYIIEAAPRQCIELYFDEKYSIEPSW 94

  Fly   225 TCEADNCQVRLDFTDFQLGLTSTLEIFDSNGQMLDSYTGEHFRPPITVSSGKSLLLQ-FRGNSAT 288
            .|:.|:.:||    |...|.:          .::..:.|:. .||:..|||:.|.:: |......
Mouse    95 ECKFDHIEVR----DGPFGFS----------PIIGRFCGQQ-NPPVIKSSGRFLWIKFFADGELE 144

  Fly   289 GVGFRAEVSFVSSKQLKD-ERLVPYTDCGGMVTGPGGAITMMNMIE--NATDVRLFDCIWIIK-- 348
            .:||.|..:|......|| ..|.|...|...:.||.|.:..:.:::  .|:.....||.|.|:
Mouse   145 SMGFSARYNFTPDPDFKDLGVLKPLPACEFEMGGPEGIVESIQILKEGKASASEAVDCKWYIRAP 209

  Fly   349 PGNNYMMMKTHISLRVDDFYGM-----AARSELTIRQGTTSDAVEIENVMWPNNGLSKESHVAPI 408
            |       ::.|.||..| |.|     ..|:.:.:..|::|    :|::        |....:.:
Mouse   210 P-------RSKIYLRFLD-YEMQNSNECKRNFVAVYDGSSS----VEDL--------KAKFCSTV 254

  Fly   409 LNGYYIRL-RGVFGM-------SSKLAIVYSVFNYLNCYIGSEFLCGNNHCISIRLHCDGFDHCG 465
            .|...:|. .||..|       :|:..::::.|....|. |:.|.|.:|.||:..|.|:|..:|.
Mouse   255 ANDVMLRTGLGVIRMWADEGSRNSRFQMLFTSFQEPPCE-GNTFFCHSNMCINNTLVCNGLQNCV 318

  Fly   466 DGSDEPDSCEEDWAHLHHDRRWYSHKPNYYFPKIDQYPDLKTATGIF--IISTLG-IFGVLSGWM 527
            ...|| :.|:|                             |..|.:.  :.:|.| :.||.|..:
Mouse   319 YPWDE-NHCKE-----------------------------KRKTSLLDQLTNTSGTVIGVTSCIV 353

  Fly   528 VILYRMGVRARHQRELQSHLQTISELLDRQDEDRT----PDEPPSYE--------APPDYEEVIK 580
            :||..:.|..:.::..:.::|.      :.|.|:|    ..|||.||        |..|:.:|
Mouse   354 IILIIVSVIVQIKQPRKKYVQR------KSDFDQTVFQEVFEPPHYELCTLRGTGATADFADV-- 410

  Fly   581 VGMQQELREPRRQRRARRAPPRDRSCSRAASNC------------------TVQSVLPL------ 621
               .::.....:.||:......|..|....|:.                  ..|.|.||
Mouse   411 ---AEDFENYHKLRRSSSKCIHDHHCGSQLSSAKGSRSNLSTRDASILAEIPTQPVKPLIPPVNR 472

  Fly   622 -------HR-------SCTLERDQEQPSTSAAAMTH 643
                   |.       :|.::..:|.|:||.....|
Mouse   473 RNILVMKHNYSQDAADACDIDEIEEVPTTSHRLSRH 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Culd	NP_729364.1	CUB	200..298	CDD:238001	26/120 (22%)
Culd	NP_729364.1	LDLa	442..472	CDD:238060	11/29 (38%)
Neto1	NP_659195.3	CUB	51..154	CDD:238001	26/117 (22%)
		CUB	<200..286	CDD:238001	22/105 (21%)
		LDLa	291..326	CDD:412164	13/36 (36%)
		PDZ-binding	531..533
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000