Protein Alignment Culd and Lrp12

DIOPT Version :10

• Sequence 1: NP_729364.1
• Gene: Culd / 38946
• FlyBaseID: FBgn0035880
• Length: 965
• Species: Drosophila melanogaster
• Sequence 2: XP_006520965.1
• Gene: Lrp12 / 239393
• MGIID: 2443132
• Length: 859
• Species: Mus musculus
• Alignment Length: 881
• Identity: 184/881 - (20%)
• Similarity: 280/881 - (31%)
• Gaps: 343/881 - (38%)

  Fly    21 WPGEAYPASSSYRDLDICNHWDGRRHFLELGSPAGEVHARNVTTTAYRSSPLVFKNDAVAGDVWY 85
            ||.: |||..:      |: |      |...:| ||:    :|        :.|::..:.|.  .
Mouse    66 WPSD-YPAQVN------CS-W------LIRANP-GEI----IT--------ISFQDFDIQGS--R 101

  Fly    86 QCSLELVTCAECVIRVAFTYANFS--KSCGNTGGKSSMCPCEHIQFSEPPYDSTISGQE-----F 143
            :|:|:.:|..        ||.|..  ::||:|              ..|||   ||.|:     |
Mouse   102 RCTLDWLTIE--------TYKNIESYRACGST--------------IPPPY---ISSQDHVWIRF 141

  Fly   144 CGDGKVFRSKTRTLQLKFFYRASNAHVFSLQYFSERNVRIVSGSPKQSIVGNG------------ 196
            ..|..|.|..                 |.|.|||.........:..|...|||
Mouse   142 HSDDSVSRKG-----------------FRLAYFSAGKSEQPDCACDQFRCGNGKCIPEAWKCNSM 189

  Fly   197 ---STKSQPQV--------ISTPYFPMAYPRDYGIEH---ILTC--EADNCQVRLDFTDFQLGLT 245
               ...|..:|        .:|.:.|.||.:...:..   :.||  |:..|...:|..|  ||
Mouse   190 DECGDSSDEEVCASDAHPPTTTAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLD--LG-- 250

  Fly   246 STLEIFDSN----GQMLDSYTG-------EHFRPP-------ITVSSGKSLLLQFRGNSATGVGF 292
               :..|.:    ||.|..:.|       ..|.||       |.....:.::|:|......|.|:
Mouse   251 ---DEIDCDMPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGY 312

  Fly   293 RAEVSFVSSKQLKDERLV----------PYTDCGGMVTGPGGAITMMNMIENATDVRLFD----- 342
            ...|......:....:|:          |.|     |....|.|.:....:.....|.|:
Mouse   313 GDYVKIYDGLEENPRKLLRVLTAFDSHAPLT-----VVSSSGQIRVHFCADKVNAARGFNATYQV 372

  Fly   343 ---CI-WIIKPGNNYMMMKTHISLRVDDFY-----------GMAARSELTI-RQGT---TSDAVE 388
               |: |.|..|.|:.....  ..|.|.::           .|..:.|... |.|.   .||...
Mouse   373 DGFCLPWEIPCGGNWGCYTE--QQRCDGYWHCPNGRDEINCTMCQKEEFPCSRNGVCYPRSDRCN 435

  Fly   389 IENVMWPNNGLSKESHVAPILNGYYIRLRGVFGMSSKLAIVYSVFNYLNCYI--GSEFLCGNNHC 451
            .:| ..||....|                                   ||:.  ...|.|.||.|
Mouse   436 YQN-HCPNGSDEK-----------------------------------NCFFCQPGNFHCKNNRC 464

  Fly   452 ISIRLHCDGFDHCGDGSDEPDSCEEDWAHLHHDRRWYSHKPNYYFPKIDQYPDLKTATGIFIIST 516
            :.....||..|.||||||| ::|                      |.|       ..|.:...:.
Mouse   465 VFESWVCDSQDDCGDGSDE-ENC----------------------PVI-------VPTRVITAAV 499

  Fly   517 LG--IFGVLSGWMVI-------LYRMGVRARHQRELQSHLQTI-SELLDRQDEDRTPDEPPSYEA 571
            :|  |.|:|   :||       ||  .:|...:|..::.|..: :|||.|             ||
Mouse   500 IGSLICGLL---LVIALGCTCKLY--SLRMFERRSFETQLSRVEAELLRR-------------EA 546

  Fly   572 PPDYEEVIKVGM-----------------QQELREPRRQR---RARRAPPRDRSC---------- 606
            ||.|.::|..|:                 .:.||...|.:   .:.|.|...||.
Mouse   547 PPSYGQLIAQGLIPPVEDFPVCSPNQASVLENLRLAVRSQLGFTSIRLPMTGRSSNIWNRIFNFA 611

  Fly   607 -SRAASNCTVQS-----VLPLHRSCTLERDQEQPSTSAAAMTHAVAATDTTEDAEHVQT------ 659
             ||.:.:..:.|     |:| .:|.:.|.::.:|..|    ..:|.:.||..:.|...|
Mouse   612 RSRHSGSLALVSGDGDEVVP-SQSSSRETERSRPHRS----LFSVESDDTDTENERRDTAGASGG 671

  Fly   660 ----MAQRMLLATAICGTAGTSLPAAKES-------GQRVQSVGISTSPSSLSAGGELPTAGGSA 713
                :.|::...||:..|.|:...::.:|       |:.|.||   .:||...|..:|.:|
Mouse   672 VAAPLPQKVPPTTAVEATVGSGGNSSAQSTRGGHADGREVSSV---EAPSVSPARHQLTSA---- 729

  Fly   714 TTPGSTADECTQGGDSLSISLTLGLPSTTAE--SPV 747
                  ....|||  ...:..|||..|:|.:  ||:
Mouse   730 ------LSRMTQG--LRWVRFTLGRSSSTTQNRSPL 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Culd	NP_729364.1	CUB	200..298	CDD:238001	28/128 (22%)
		LDLa	442..472	CDD:238060	15/29 (52%)
Lrp12	XP_006520965.1	CUB	56..158	CDD:238001	36/162 (22%)
		LDLa	167..201	CDD:238060	5/33 (15%)
		LDLa	216..255	CDD:238060	10/45 (22%)
		CUB	268..372	CDD:238001	18/108 (17%)
		LDLa	414..449	CDD:238060	9/70 (13%)
		LDLa	452..486	CDD:238060	15/34 (44%)