DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Culd and Sorl1

DIOPT Version :9

Sequence 1:	NP_729364.1	Gene:	Culd / 38946	FlyBaseID:	FBgn0035880	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_035566.2	Gene:	Sorl1 / 20660	MGIID:	1202296	Length:	2215	Species:	Mus musculus

Alignment Length:	466	Identity:	101/466 - (21%)
Similarity:	139/466 - (29%)	Gaps:	179/466 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 TTAYR--SSPLVFKNDAVAGDVW-YQCSLELVTCAECVIRVAFTYANFSKSCGNTGGKSSMCPCE 125
            :.|||  |..:.:.|.......| |.....|    :|:.|:.|           :|.:.|:
Mouse   910 SAAYRLVSEDVKWPNGISVDSQWIYWTDAYL----DCIERITF-----------SGQQRSV---- 955

  Fly   126 HIQFSEP-PYDSTISGQEFCGDG----KVFRSK--------------TRTLQLKFFYRASNAHVF 171
             |..|.| ||...:...|...|.    .:||:.              |..:.:|.||:..||
Mouse   956 -ILDSLPHPYAIAVFKNEIYWDDWSQLSIFRASKHSRSQVEILASQLTGLMDMKVFYKGKNA--- 1016

  Fly   172 SLQYFSERNVRIVSGSPKQSIVGNGSTKSQPQVISTPYFPMAYPRDYGIEHILTCEADNCQVRLD 236
                                    ||....||..|....|.|       .:..:|....
Mouse  1017 ------------------------GSNACVPQPCSLLCLPKA-------NNSKSCRCPE------ 1044

  Fly   237 FTDFQLGLTSTLEIFDSNGQMLDSYTGEHFRPPITVSSGKSLLL-QFR---GNSATGVGFRAEVS 297
                  |:.|:  :..|...|.|...|...:....|....:.|. |:|   ||....:.:   ..
Mouse  1045 ------GVASS--VLPSGDLMCDCPQGYQRKNNTCVKEENTCLRNQYRCSNGNCINSIWW---CD 1098

  Fly   298 FVSS-KQLKDERLVPYTDCGGMVTGPGGAITMMNMIENATDVRLF-------DCIWIIKPGNNYM 354
            |.:. ..:.|||..|.|.|        .|.|.....|:.|.:.|.       ||      |:|
Mouse  1099 FDNDCGDMSDERNCPTTVC--------DADTQFRCQESGTCIPLSYKCDLEDDC------GDN-- 1147

  Fly   355 MMKTHISL---RVDDF---YGMAARSELTIRQGTTSDAVEIENVMWPNNG------LSKESHVAP 407
            ..::|..:   |.|:|   .||..||.                  |..:|      .|.|::...
Mouse  1148 SDESHCEMHQCRSDEFNCSSGMCIRSS------------------WVCDGDNDCRDWSDEANCTA 1194

  Fly   408 ILNGYYIRLRGVFGMSSKLAIVYSVFNYLNCYIGSEFLCGNNHCISIRLHCDGFDHCGDGSDE-P 471
            |                          |..|. .|.|.|.|.|||..|..|||...|.||||| |
Mouse  1195 I--------------------------YHTCE-ASNFQCHNGHCIPQRWACDGDADCQDGSDEDP 1232

  Fly   472 DSCEEDWAHLH 482
            .|||:.....|
Mouse  1233 VSCEKKCNGFH 1243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Culd	NP_729364.1	CUB	200..298	CDD:238001	18/101 (18%)
Culd	NP_729364.1	LDLa	442..472	CDD:238060	17/30 (57%)
Sorl1	NP_035566.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	59..84
		VPS10	124..753	CDD:214740
		BNR 1	136..147
		BNR 2	232..243
		BNR 3	441..452
		BNR 4	521..532
		BNR 5	562..573
		Sortilin_C	588..753	CDD:292523
		LY	780..821	CDD:214531
		LDL-receptor class B 1	800..843
		LY	824..866	CDD:214531
		LDL-receptor class B 2	844..887
		LY	868..910	CDD:214531	101/466 (22%)
		LDL-receptor class B 3	888..932		5/21 (24%)
		Ldl_recept_b	890..929	CDD:278487	5/18 (28%)
		LY	913..953	CDD:214531	11/54 (20%)
		LDL-receptor class B 4	933..972		12/58 (21%)
		LDL-receptor class B 5	973..1013		7/39 (18%)
		LDLa	1078..1112	CDD:238060	9/36 (25%)
		LDLa	1117..1153	CDD:238060	10/51 (20%)
		Ldl_recept_a	1157..1192	CDD:278486	11/52 (21%)
		Ldl_recept_a	1198..1230	CDD:278486	16/32 (50%)
		LDLa	1240..1271	CDD:238060	1/4 (25%)
		LDLa	1281..1308	CDD:197566
		LDLa	1325..1359	CDD:238060
		LDLa	1373..1403	CDD:238060
		LDLa	1419..1453	CDD:238060
		LDLa	1471..1506	CDD:238060
		LDLa	1514..1549	CDD:238060
		FN3	1557..1630	CDD:238020
		FN3	1651..1742	CDD:238020
		FN3	1752..1831	CDD:238020
		FN3	1935..2022	CDD:238020
		FN3	2026..2113	CDD:238020
		Potential nuclear localization signal for the C-terminal fragment generated by PSEN1. /evidence=ECO:0000250\|UniProtKB:Q92673	2162..2165
		Endocytosis signal. /evidence=ECO:0000255	2173..2178
		Required for efficient Golgi apparatus -endosome sorting. /evidence=ECO:0000250\|UniProtKB:Q92673	2191..2215
		Required for interaction with GGA1 and GGA2. /evidence=ECO:0000250\|UniProtKB:Q92673	2202..2215
		DXXLL motif involved in the interaction with GGA1. /evidence=ECO:0000250\|UniProtKB:Q92673	2209..2213
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900