DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Culd and Lrp5

DIOPT Version :9

Sequence 1:	NP_729364.1	Gene:	Culd / 38946	FlyBaseID:	FBgn0035880	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_032539.2	Gene:	Lrp5 / 16973	MGIID:	1278315	Length:	1614	Species:	Mus musculus

Alignment Length:	501	Identity:	104/501 - (20%)
Similarity:	158/501 - (31%)	Gaps:	168/501 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 KSCGNTGGKSSM--CPCEHIQFSEPPYD-----------------STISGQEFCGD--GKVF--- 150
            |...:.|.:.||  .|.:.:.....|:|                 :||:.....||  |.|.
Mouse  1000 KRAKDDGTQPSMLTSPSQSLSPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLDGDAMGVVLRGD 1064

  Fly   151 RSKTRTLQLK-----FFYRASNAHVFSLQYFS----ERNVRIVSG--SPKQSIVGNGSTKSQPQV 204
            |.|.|.:.:.     .::.....|...::..|    ||.|...:|  .|...:|.|...|
Mouse  1065 RDKPRAIAVNAERGYMYFTNMQDHAAKIERASLDGTEREVLFTTGLIRPVALVVDNALGK----- 1124

  Fly   205 ISTPYFPMAYPRDYGIEHILTCEADNCQVRLDFTDFQL----GLT---STLEIFDSNGQML---D 259
                    .:..|..::.|.:|:..... ||...|..:    |||   ..|...|...||:   :
Mouse  1125 --------LFWVDADLKRIESCDLSGAN-RLTLEDANIVQPVGLTVLGRHLYWIDRQQQMIERVE 1180

  Fly   260 SYTGEHFRPPITVSSGKSLLLQFRGNSATGVGFRAEVSFVSSKQLKDERLVPYT-DCGG-----M 318
            ..||:           |...:|.|....||:....|||      |::....|.. |.||     :
Mouse  1181 KTTGD-----------KRTRVQGRVTHLTGIHAVEEVS------LEEFSAHPCARDNGGCSHICI 1228

  Fly   319 VTGPG--------GAITMMNMI-----------ENATDVRLFDCIWIIKPGNNYMMMKTHISLRV 364
            ..|.|        ..:.:.|::           :.|......|||    ||          :.|.
Mouse  1229 AKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACTTGEIDCI----PG----------AWRC 1279

  Fly   365 DDFYGMAARSELTIRQGTTSDAVEIENVMWPNNGLSKESHVAPILNGYYIRLR----GVFGMSSK 425
            |.|...|.:|:   .:|.            |....|:    .|...|..:.||    |......:
Mouse  1280 DGFPECADQSD---EEGC------------PVCSASQ----FPCARGQCVDLRLRCDGEADCQDR 1325

  Fly   426 LAIVYSVFNYLNC---YIGSEFLCGNNHCISIRLHCDGFDHCGDGSDEPDSCEEDWAHLHHDRRW 487
                   .:..||   .:.::|.|.:..|:.|:..||.|..|.|||||. .||.:
Mouse  1326 -------SDEANCDAVCLPNQFRCTSGQCVLIKQQCDSFPDCADGSDEL-MCEIN---------- 1372

  Fly   488 YSHKPNYYFPKIDQYPDLKTATGIFIISTLGIFGVLSGWMVILYRM 533
                    .|..|..|...:|.|..|...|.:| |:.|...:..|:
Mouse  1373 --------KPPSDDIPAHSSAIGPVIGIILSLF-VMGGVYFVCQRV 1409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Culd	NP_729364.1	CUB	200..298	CDD:238001	22/107 (21%)
Culd	NP_729364.1	LDLa	442..472	CDD:238060	13/29 (45%)
Lrp5	NP_032539.2	Beta-propeller 1	31..287
		NHL	<36..>168	CDD:302697
		NHL repeat	64..103	CDD:271320
		LY	101..141	CDD:214531
		NHL repeat	106..147	CDD:271320
		Ldl_recept_b	162..202	CDD:278487
		LY	186..228	CDD:214531
		LY	229..270	CDD:214531
		LDL-receptor class B 5	247..289
		FXa_inhibition	298..335	CDD:291342
		Beta-propeller 2	340..601
		LY	365..405	CDD:214531
		LY	407..449	CDD:214531
		LY	450..493	CDD:214531
		LY	494..536	CDD:214531
		LY	537..570	CDD:214531
		FXa_inhibition	604..639	CDD:291342
		Beta-propeller 3	643..902
		NHL	684..877	CDD:302697
		LY	709..751	CDD:214531
		NHL repeat	719..755	CDD:271320
		NHL repeat	762..801	CDD:271320
		NHL repeat	807..842	CDD:271320
		NHL repeat	846..870	CDD:271320
		FXa_inhibition	905..940	CDD:291342
		Beta-propeller 4	944..1211		50/241 (21%)
		LY	969..1008	CDD:214531	2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1002..1025		4/22 (18%)
		LY	1059..1102	CDD:214531	6/42 (14%)
		LY	1103..1145	CDD:214531	9/55 (16%)
		FXa_inhibition	1216..1252	CDD:291342	6/35 (17%)
		LDLa	1258..1294	CDD:238060	11/52 (21%)
		LDLa	1297..1331	CDD:238060	6/44 (14%)
		LDLa	1335..1369	CDD:238060	13/34 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1474..1498
		PPPSP motif A	1499..1505
		PPPSP motif B	1537..1544
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1567..1599
		PPPSP motif C	1573..1580
		PPPSP motif D	1590..1595
		PPPSP motif E	1604..1611
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900