DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Culd and Lrp2

DIOPT Version :9

Sequence 1:	NP_729364.1	Gene:	Culd / 38946	FlyBaseID:	FBgn0035880	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	NP_001074557.1	Gene:	Lrp2 / 14725	MGIID:	95794	Length:	4660	Species:	Mus musculus

Alignment Length:	582	Identity:	111/582 - (19%)
Similarity:	166/582 - (28%)	Gaps:	243/582 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   438 CYIGSEFLCGNNHCISIRLHCDGFDHCGDGSDE----PDSCEEDWAHLHHDR----RWYSHKPNY 494
            |:...:|.|||:|||.:|..|||.|.|||.|||    |..|.|........:    ||...:.|.
Mouse  3721 CHPSGDFRCGNHHCIPLRWKCDGIDDCGDNSDEESCVPRECTESEFRCADQQCIPSRWVCDQEND 3785

  Fly   495 YFPKIDQ--------YPD-LKTATGIFIISTLGIFGVLSGWMVILYRMGVRARHQRELQSHLQTI 550
            .....|:        :|: .:..:|..:...|...|              ||
Mouse  3786 CGDNSDERDCEMKTCHPEHFQCTSGHCVPKALACDG--------------RA------------- 3823

  Fly   551 SELLDRQDEDRTPDEPPSYEAPP------------------DYEEVIKVGMQQEL--------RE 589
             :.||..||...|...|:....|                  |.|.....|..:|:        ..
Mouse  3824 -DCLDASDESACPTRFPNGTYCPAAMFECKNHVCIQSFWICDGENDCVDGSDEEIHLCFNVPCES 3887

  Fly   590 PRRQRRARRAPPRDRSCSRAASNCTVQSVL--------------------PLHRSCTLERDQEQP 634
            |:|.|           |..  |.|.....|                    |.|:.||   |.|..
Mouse  3888 PQRFR-----------CDN--SRCIYGHQLCNGVDDCGDGSDEKEEHCRKPTHKPCT---DTEYK 3936

  Fly   635 STSAAAMT-HAVAATDTTEDAEHVQTMAQRMLLATAICG----TAGTSLPAAKESGQRVQSVGIS 694
            .::...:: |.|.  |..:|                 ||    ..|.:|...:...:::    ..
Mouse  3937 CSNGNCVSQHYVC--DNVDD-----------------CGDLSDETGCNLGENRTCAEKI----CE 3978

  Fly   695 TSPSSLSAGGELPTAGGSATTPGSTADECTQGGDSLSISLTLGLPSTTAESPVTTDQNQLQKQSP 759
            .:.:.||.||.:     .:..||.                          .|.|.|:|..
Mouse  3979 QNCTQLSNGGFI-----CSCRPGF--------------------------KPSTLDKNSC----- 4007

  Fly   760 EQTISNCTEHTFLKRSWLVVQQVPPGRGYRVRRLRHTFSSPEAFTSDELHLPYPDFLSYGTNLPH 824
             |.|:.|.|.....:|                 .|::..|.|.|..|..
Mouse  4008 -QDINECEEFGICPQS-----------------CRNSKGSYECFCVDGF---------------- 4038

  Fly   825 ERSSSNFGSELSRDPSSYSVGKRARLTPEDTS------GSETITQEMEQSNQTLQSHVIVESHPN 883
            :..|:::|...:.|.|...:     |.||:..      .||..::.:|:           |.|..
Mouse  4039 KSMSTHYGERCAADGSPPLL-----LLPENVRIRKYNISSEKFSEYLEE-----------EEHIQ 4087

  Fly   884 HSESESEAE------------QQVSCFGAVAQRPKRRHRGHVRSRSFSNARGGSAGRRRLMQ 933
            ..:.:.:.|            .|.|.|||:    ||.:.....|.|.:..|....|.:.|||
Mouse  4088 AIDYDWDPEGIGLSVVYYTVLSQGSQFGAI----KRAYLPDFESGSNNPVREVDLGLKYLMQ 4145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Culd	NP_729364.1	CUB	200..298	CDD:238001
Culd	NP_729364.1	LDLa	442..472	CDD:238060	18/33 (55%)
Lrp2	NP_001074557.1	LDLa	28..62	CDD:238060
		LDLa	67..99	CDD:197566
		LDLa	108..142	CDD:238060
		LDLa	148..179	CDD:238060
		LDLa	183..217	CDD:238060
		LDLa	222..256	CDD:238060
		LDLa	265..299	CDD:238060
		LDL-receptor class B 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	435..477
		LY	460..500	CDD:214531
		LDL-receptor class B 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	478..520
		LY	502..547	CDD:214531
		LDL-receptor class B 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	521..567
		LY	550..590	CDD:214531
		LDL-receptor class B 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	568..612
		FXa_inhibition	662..703	CDD:291342
		LDL-receptor class B 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	752..794
		LY	775..817	CDD:214531
		LDL-receptor class B 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	795..836
		LDL-receptor class B 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	837..880
		Ldl_recept_b	837..877	CDD:278487
		LY	863..903	CDD:214531
		LDL-receptor class B 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	881..924
		FXa_inhibition	980..1012	CDD:291342
		LDLa	1025..1059	CDD:238060
		Ldl_recept_a	1065..1101	CDD:278486
		LDLa	1110..1144	CDD:238060
		LDLa	1150..1184	CDD:238060
		LDLa	1188..1223	CDD:238060
		LDLa	1231..1263	CDD:197566
		LDLa	1272..1306	CDD:238060
		LDLa	1313..1345	CDD:197566
		FXa_inhibition	1354..1389	CDD:291342
		EGF_CA	1391..1430	CDD:214542
		LDL-receptor class B 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1479..1521
		LY	1502..1544	CDD:214531
		LDL-receptor class B 10. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1522..1564
		LY	1546..1590	CDD:214531
		LDL-receptor class B 11. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1567..1610
		LY	1592..1633	CDD:214531
		LDL-receptor class B 12. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1611..1655
		LDL-receptor class B 13. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1656..1696
		LDL-receptor class B 14. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1791..1833
		LDL-receptor class B 15. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1834..1883
		LDL-receptor class B 16. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1884..1931
		Ldl_recept_b	1884..1928	CDD:278487
		LY	1912..1954	CDD:214531
		LDL-receptor class B 17. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1932..1973
		LDL-receptor class B 18. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	1974..2014
		FXa_inhibition	2023..2059	CDD:291342
		LDL-receptor class B 19. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2108..2157
		LDL-receptor class B 20. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2158..2202
		LY	2183..2226	CDD:214531
		LDL-receptor class B 21. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2203..2246
		LY	2228..2268	CDD:214531
		LDL-receptor class B 22. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2247..2290
		LDL-receptor class B 23. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2291..2333
		FXa_inhibition	2347..2383	CDD:291342
		LDL-receptor class B 24. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2432..2478
		LY	2460..2501	CDD:214531
		LDL-receptor class B 25. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2479..2519
		LY	2503..2543	CDD:214531
		LDL-receptor class B 26. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2520..2563
		LDL-receptor class B 27. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2564..2605
		LDL-receptor class B 28. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	2606..2647
FXa_inhibition	2656..2693	CDD:291342
LDLa	2700..2732	CDD:197566
LDLa	2742..2776	CDD:238060
LDLa	2783..2818	CDD:238060
LDLa	2822..2855	CDD:197566
LDLa	2865..2899	CDD:238060
LDLa	2908..2939	CDD:197566
LDLa	2950..2986	CDD:197566
LDLa	2995..3029	CDD:238060
LDLa	3034..3066	CDD:238060
LDLa	3077..3111	CDD:238060
cEGF	3134..3157	CDD:289433
vWFA	<3149..3192	CDD:294047
LY	3221..3262	CDD:214531
LDL-receptor class B 29. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3241..3283
LY	3264..3306	CDD:214531
Ldl_recept_b	3284..3331	CDD:278487
LDL-receptor class B 30. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3284..3326
LDL-receptor class B 31. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3335..3378
Ldl_recept_b	3335..3375	CDD:278487
LY	3360..3401	CDD:214531
LDL-receptor class B 32. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3379..3421
LY	3406..3443	CDD:214531
LDL-receptor class B 33. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	3422..3462
FXa_inhibition	3471..>3500	CDD:291342
LDLa	3514..3548	CDD:238060
LDLa	3555..3586	CDD:197566
LDLa	3595..3627	CDD:197566
LDLa	3636..3668	CDD:197566
LDLa	3684..3716	CDD:238060
LDLa	3723..3756	CDD:238060	18/32 (56%)
LDLa	3761..3795	CDD:238060	6/33 (18%)
LDLa	3800..3834	CDD:238060	10/61 (16%)
LDLa	3844..3876	CDD:238060	4/31 (13%)
LDLa	3887..3917	CDD:197566	7/42 (17%)
LDLa	3930..3964	CDD:238060	10/55 (18%)
EGF_CA	4009..4049	CDD:214542	11/72 (15%)
LY	4143..4178	CDD:214531	3/3 (100%)
LDL-receptor class B 34. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	4156..4198
LDL-receptor class B 35. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	4199..4242
Ldl_recept_b	4199..4239	CDD:278487
LY	4224..4266	CDD:214531
LDL-receptor class B 36. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00461	4244..4285
SH3-binding. /evidence=ECO:0000255	4454..4463
PxLPxI/L motif 1, mediates interaction with ANKRA2. /evidence=ECO:0000250\|UniProtKB:P98158	4457..4462
PxLPxI/L motif 2, mediates interaction with ANKRA2. /evidence=ECO:0000250\|UniProtKB:P98158	4460..4465
Endocytosis signal. /evidence=ECO:0000255	4522..4527
Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4558..4660
Interaction with DAB2. /evidence=ECO:0000250\|UniProtKB:P98164	4597..4610
NPXY motif	4603..4606
SH2-binding. /evidence=ECO:0000255	4606..4609
SH3-binding. /evidence=ECO:0000255	4619..4630
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900