DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Culd and lrp3

DIOPT Version :9

Sequence 1:	NP_729364.1	Gene:	Culd / 38946	FlyBaseID:	FBgn0035880	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	XP_009301583.1	Gene:	lrp3 / 100170796	ZFINID:	ZDB-GENE-080116-3	Length:	824	Species:	Danio rerio

Alignment Length:	1027	Identity:	198/1027 - (19%)
Similarity:	289/1027 - (28%)	Gaps:	412/1027 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 WPGEAYPA----------------SSSYRDLDICNHWDGRRHFLELGSPAGEVHAR---NVTTTA 66
            ||.. |||                :.|:...|:....|.|..:|.|| |..:...|   :|....
Zfish    50 WPLN-YPAGVNCSWNIQGSRGDVITISFHSFDLEETGDCRGDWLLLG-PTWKAEYRLCGSVLPPP 112

  Fly    67 YRSSPLVFKNDAVAGDVWY---------------------------QCSLELVTC--AECVIRVA 102
            :.||         .|.||.                           .|..:...|  .:||.|
Zfish   113 FISS---------RGRVWVYFHSHANSSGQAQGFRMSYIRGRLGQSSCEKDEYLCGNGKCVPR-- 166

  Fly   103 FTYANFSKSCGN-----------TGGKSSMCP-----CEHIQFSE-PPYDSTISGQEFCGDGKVF 150
            ....|....||:           |..::|:||     |..:|.:. .|.....:|...|.||
Zfish   167 SWRCNGLDECGDNTDERNCVAPPTPARASLCPPGTLQCSDVQSTRCLPGSLRCNGARDCPDG--- 228

  Fly   151 RSKTRTLQLKFFYRASNAHVFSLQYFSERNVRIVSGSPKQSIVGNGSTKSQPQVISTPYFPMAYP 215
                                       ....|....|..:.:|....|.:.|
Zfish   229 ---------------------------SDEARCPDTSCGKRLVNFYGTFASP------------- 253

  Fly   216 RDYGIEHILTCEADNCQVRLDF---------TDFQLGLTSTLEIFDSNGQMLD------SYTGEH 265
             |:...:..|....:|...||.         .|.|||:..::.::|..|:..:      |:...|
Zfish   254 -DFFRPNRSTGTDLHCTWFLDTKDPKPLVLQVDLQLGVGDSVRVYDGLGEQAERLLQSLSHHNNH 317

  Fly   266 FRPPITVSSGKSLLLQFRGNSATGVGFRAEVSFVSSKQLK------------DERLVPYTD---C 315
            .|..:..|.|:..:.......:.|.||.|      :.|:|            ||..  |:|   |
Zfish   318 RRALLESSQGQMSIFYHAKPHSPGHGFNA------TYQVKGYCFPGEHPCGTDEGC--YSDLQRC 374

  Fly   316 GGMVTGPGGAITMMNMIENATDVRLFDCIWIIKPGNNYMMMKTHISLRVDDFY----GMAA---R 373
            .|....|||              |..:...:.:||.                |    |..|   .
Zfish   375 DGYWHCPGG--------------RDEEACPLCQPGE----------------YPCEGGSGACYSA 409

  Fly   374 SELTIRQGTTSDAVEIENVMWPNNGLSKESHVAPILNGYYIRLRGVFGMSSKLAIVYSVFNYLNC 438
            ||....|....|                                   |...|        |..:|
Zfish   410 SERCNNQKKCPD-----------------------------------GSDEK--------NCFDC 431

  Fly   439 YIGSEFLCGNNHCISIRLHCDGFDHCGDGSDEPDSCEEDWAHLHHDRRWYSHKPNYYFPKIDQYP 503
            ..|: |.||.|.||.....|||.:.|.|||||.|....                   .|:
Zfish   432 QPGN-FHCGTNLCIFETWRCDGQEDCMDGSDERDCLAS-------------------VPR----- 471

  Fly   504 DLKTATGIFIISTL-GIFGVLS-GWMVILYRMGVRARHQRELQSHLQTI-SELLDRQDEDRTPDE 565
              |..|...|.|.: |:..|:: |....||  .:|.|..|..::.:..: :|.:.|
Zfish   472 --KVITAALIGSLVCGLLLVIALGCAFKLY--SLRTREYRAFETQMTRLEAEFVQR--------- 523

  Fly   566 PPSYEAPPDYEEVIKVGMQQELREPRRQRRARRAPPRDRSCSRAASNCTVQSVLPLHRSC---TL 627
                ||||.|.::|..|:               .||.|   .....|.|..|||...||.   .:
Zfish   524 ----EAPPSYGQLIAQGL---------------IPPVD---DFPVYNPTQASVLQNLRSAMRRQI 566

  Fly   628 ERDQEQPSTSAAAMTHAVAATDTTEDAEHVQTMAQRMLLATAICGTAGTSLPAAKESGQRVQSVG 692
            .|...:.|:|                        :|.|         |.........|.||:
Zfish   567 RRHSSRRSSS------------------------RRRL---------GRLWNRLFHRGSRVR--- 595

  Fly   693 ISTSPSSLSAGGELPTAGGSATTPGSTADECTQGGDSLSISLTLGLPSTTAESPVTTDQNQLQKQ 757
                       |::|.    .|.||.|....              .|.....|..|.|.:  .::
Zfish   596 -----------GQIPL----LTPPGHTHANT--------------YPELNLHSYNTADNS--VRE 629

  Fly   758 SPEQTISNCTEHTFLKRSWLVVQQVPP-----GRGYRVRRLRHTFSSPEAFT-SDELHLPYPDFL 816
            |||.|                 .|.||     ..|..::........|:..: :..|.||.|:.|
Zfish   630 SPETT-----------------GQTPPSCSAVALGLALQAQNDALCLPDRESPASPLSLPSPNSL 677

  Fly   817 -SYGTNLPHE-----RSSSNFGSELSRD---PSSYSVGKRARLTPEDTSGSETITQEM--EQSNQ 870
             |....|..|     |||:.....|::.   .||....:|.:.:...:..|..:.||:  |....
Zfish   678 HSTSDTLEDEDDEDDRSSAGKQGILAKHKDADSSPGPSERPKRSASRSRSSRRLVQELAAELRGV 742

  Fly   871 TLQSHVIVESHP-----NHSESESEAEQQVSCFGAVAQRPKRRHRGHVRSRS 917
            :|..:..|...|     :.:.|..::|:|.||.........:..|||.|..|
Zfish   743 SLLRYTSVGISPLSSPESPTSSSGQSEEQRSCPAFRKAHKDKDDRGHSRESS 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Culd	NP_729364.1	CUB	200..298	CDD:238001	21/112 (19%)
Culd	NP_729364.1	LDLa	442..472	CDD:238060	15/29 (52%)
lrp3	XP_009301583.1	CUB	31..141	CDD:238001	20/101 (20%)
		LDLa	151..185	CDD:238060	8/35 (23%)
		LDLa	197..234	CDD:238060	9/66 (14%)
		CUB	239..350	CDD:238001	23/130 (18%)
		LDLa	354..389	CDD:238060	10/50 (20%)
		LDLa	392..428	CDD:238060	11/94 (12%)
		LDLa	431..465	CDD:238060	17/34 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900