DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Culd and neto2b

DIOPT Version :9

Sequence 1:	NP_729364.1	Gene:	Culd / 38946	FlyBaseID:	FBgn0035880	Length:	965	Species:	Drosophila melanogaster
Sequence 2:	XP_003200473.1	Gene:	neto2b / 100034584	ZFINID:	ZDB-GENE-060503-638	Length:	537	Species:	Danio rerio

Alignment Length:	546	Identity:	123/546 - (22%)
Similarity:	209/546 - (38%)	Gaps:	149/546 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 RNVRIVSGSPKQ--SIV--GNGSTKSQPQVIST-------PYFPMAYPRD---------YGIEHI 223
            :||.:....|..  ::|  .||.|.|.|...||       .|...|:||.         |.||..
Zfish    27 QNVAVADKKPAHCGTLVQTENGGTFSSPNYPSTYPPNKECVYILEAHPRKRIQLVFDDIYHIEPS 91

  Fly   224 LTCEADNCQVRLDFTDFQLGLTSTLEIFDSNGQMLDSYTGEHFRPPITVSSGKSLLLQFRGN-SA 287
            ..|..||.::|    |...       ||   ..:::.:.|:. .|.|..|||:.|.::|..: ..
Zfish    92 FECRFDNIEIR----DGPF-------IF---SPLINRFCGDK-SPGIVTSSGRFLWIKFTSDEEL 141

  Fly   288 TGVGFRAEVSFVSSKQLK---DERLVPYTDCGGMVTGPGGAITMMNMIENATDVR---LFDCIWI 346
            ..:||:.|.|:.:.....   ...|.|..||...::|..|.| ..:.:|....|:   ..||||.
Zfish   142 EELGFKVEYSYTADPDFHLHVGGLLNPIPDCQFEMSGADGVI-RSSQVEEENKVKAGEAVDCIWT 205

  Fly   347 IK--PGNNYMMMKTHISLRVDDFY----GMAARSELTIRQGTTSDAVEIENVMWPN---NGLSKE 402
            |:  |     |.|  |.||..|:.    ....::.:.:.:|  |:|:|.....:.:   |.::.:
Zfish   206 IRAPP-----MSK--IYLRFLDYQLENSNECKKNFVAVYEG--SNAIEDLKAKFCSTVANDITLD 261

  Fly   403 SHVAPILNGYYIRLRGVFGMSSKLA---IVYSVFNYLNCYIGSEFLCGNNHCISIRLHCDGFDHC 464
            :.||.:        |.....:|||:   ::::||....|...:.| |.:|.||:..|.|:|..:|
Zfish   262 NTVAVV--------RMWADETSKLSRFRLLFTVFTEPPCSPNAYF-CHSNMCINNTLVCNGVQNC 317

  Fly   465 GDGSDEPDSCEEDWAHLHHDRRWYSHKPNYYFPKIDQYPDLKTATGIFIISTLGIFGVLSGWMVI 529
            ....|| ::|.|             .||..:|.::.     ||...:..:||    ||:.  :::
Zfish   318 VFPWDE-NNCRE-------------KKPKTFFHQMS-----KTHGTVIGVST----GVVC--LLL 357

  Fly   530 LYRMGVRARHQRE---LQSHLQTISELLDRQDEDRTPDEPPSYEAPPDYE--EVIKVGMQQELRE 589
            :..:.::.:..|:   .:..|.:.:|:.:..|             ||:||  .:....|.:||.|
Zfish   358 IISIFIQMKQPRKKILCRKGLFSATEMQEVMD-------------PPEYEMFSMQDTDMPEELLE 409

  Fly   590 PRRQ--RRARRAPPRDRSCSRAASNCTVQSVLPLHRSCTLERDQEQP-----STSAAAM------ 641
            ...:  ::..|        |.:.|.|..:.....|.|.|:...:..|     ||:..|.
Zfish   410 EELEGLQKLHR--------SASMSRCIREHHCGAHNSTTILMTRTNPLSEELSTAVGARSWGSFH 466

  Fly   642 ------------THAVAATDTTEDAE 655
                        |||.:|....|..|
Zfish   467 GRRSSSRSHHPHTHAYSAQSLREALE 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Culd	NP_729364.1	CUB	200..298	CDD:238001	29/114 (25%)
Culd	NP_729364.1	LDLa	442..472	CDD:238060	11/29 (38%)
neto2b	XP_003200473.1	CUB	39..151	CDD:238001	33/126 (26%)
		CUB	<200..286	CDD:238001	23/102 (23%)
		LDLa	292..326	CDD:238060	12/35 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910