DRSC/TRiP Functional Genomics Resources

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Protein Alignment GAPcenA and RABGAP1L

DIOPT Version :9

Sequence 1:NP_001097549.1 Gene:GAPcenA / 38945 FlyBaseID:FBgn0035879 Length:1194 Species:Drosophila melanogaster
Sequence 2:NP_001353375.1 Gene:RABGAP1L / 9910 HGNCID:24663 Length:1051 Species:Homo sapiens


Alignment Length:1083 Identity:399/1083 - (36%)
Similarity:565/1083 - (52%) Gaps:180/1083 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   116 HQQKSLTLPLTGSGGGSVDPEMRFPCTLFTPKSEETLDDASSSNRVGHSVFYDCIDASPACVEEK 180
            |::|. .|.:..:|...::..|.........:....|.|..||:.:....|.| |.||.......
Human    39 HEEKP-QLKIVSNGDEQLEKAMEEILRDSEKRPSSLLVDCQSSSEISDHSFGD-IPASQTNKPSL 101

  Fly   181 QDAMKPEKGDTTDEEVSE----IDQGCTIFSGVTYLGAANINAPKSETEVYRIMGELNSGSKSVG 241
            |..:.|...:.:....|.    .::...:|:.:||||...:::|::|.|..|.|..:.|.|: ..
Human   102 QLILDPSNTEISTPRPSSPGGLPEEDSVLFNKLTYLGCMKVSSPRNEVEALRAMATMKSSSQ-YP 165

  Fly   242 LKITVSIPNCSEGLVVLHDAESNTIIATYEISSIILYYRGPVDTVENGCFAFT-WLHGDALFQCH 305
            ..:|:.:||..||.|.:.|..||..||::.|..::...||...|.|:.||||| ..||...||.|
Human   166 FPVTLYVPNVPEGSVRIIDQSSNVEIASFPIYKVLFCARGHDGTTESNCFAFTESSHGSEEFQIH 230

  Fly   306 VFRCHIPEAVNQVSACFQKAFQTYPPSMSCSLNSAVDMANSV----TSDVSGNPLNTAGYEFIVS 366
            ||.|.|.|||:::...|..||:.       |.....|:.:||    .|||         :.|.||
Human   231 VFSCEIKEAVSRILYSFCTAFKR-------SSRQVSDVKDSVIPTPDSDV---------FTFSVS 279

  Fly   367 LEIRERVAKNSYAAVPRDRG--CFKLRANTDKEVCITVKQTPSNVLQPLHIERCFGVLVAPGKLV 429
            ||::|...|.:::.||:||.  .|||:...:|:|.|||:|. ||  :.|.||||||:|::||:.|
Human   280 LEVKEDDGKGNFSPVPKDRDKFYFKLKQGIEKKVVITVQQL-SN--KELAIERCFGMLLSPGRNV 341

  Fly   430 VQKDMHLIDMHSMGYIQPGGTGVATESDSNAQQSSSWPYTIRAEWKAQEKAFEQLNLESSKTN-- 492
            ...||||:||.|||....|..                 |.|...|......|..||.|:.|..  
Human   342 KNSDMHLLDMESMGKSYDGRA-----------------YVITGMWNPNAPVFLALNEETPKDKQV 389

  Fly   493 -LTVAVDIVMRRIQEPVRFVIETPVTIQSASEMRIMDHFMSKRPMTLRFYLHLKRTE-------- 548
             :|||||:|:..:.|||||::||.|.:..|:| |..  :.|::..|..|::.||::|        
Human   390 YMTVAVDMVVTEVVEPVRFLLETVVRVYPANE-RFW--YFSRKTFTETFFMRLKQSEGKGHTNAG 451

  Fly   549 ESNWKVNSI----DPSEEITEQPGHQQSSSLLKMGMNNLSRIVRSSSIASIEDDCPSDYSSDGDE 609
            ::.::|.|:    |..|.:|...|                     ....|.:||   :...:.|.
Human   452 DAIYEVVSLQRESDKEEPVTPTSG---------------------GGPMSPQDD---EAEEESDN 492

  Fly   610 PLLSGTGEVSKDCSQDTLDEWDPILREWDSE--KRPKNLAPLVRLGVPEALREKIWQKLANVEGR 672
            .|.||||:|||||.:..|..|..:|.:|.|.  .|||.|:.||:.|||||||.::||.||.....
Human   493 ELSSGTGDVSKDCPEKILYSWGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDN 557

  Fly   673 MEMNDKYKILITKETKCETVIQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQG 737
            ..|.|:|:|||||::..|:||.||||||||||..||:.||.||::|:|:.|||:|:|.::|||||
Human   558 QAMLDRYRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQG 622

  Fly   738 LSFIAASLLLHMPEEDAFCVLVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTA 802
            .||:||.||||||||.||||||.:||||||||||:..||.|:.:.||||||:::|||.||.||:.
Human   623 QSFLAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSD 687

  Fly   803 CGIETHMYASQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGIL 867
            ..:|.|||||||||||:||:||||.|||::|:.|.:||.::|.||:.||...:.||.|.||||.|
Human   688 LNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGAL 752

  Fly   868 KYFRVTLPKKCRSSSQARKVMKQACERKI--KKLKQYEEEFLLKKQHKERLEKEAQIYENRFGEE 930
            |:|||.|||:.|:...||::|:|||..|:  ||||:||:|:  :...:.:|::|..:  :|:..|
Human   753 KFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEY--QTMRESQLQQEDPM--DRYKRE 813

  Fly   931 RRKMQA--------------------------------EIDALNKQLTSAKERAVEKE------- 956
            .|::|.                                :.|.|||:|...|:|.||.|       
Human   814 NRRLQEASMRLEQENDDLAHELVTSKIALRNDLDQAEDKADVLNKELLLTKQRLVETEEEKRKQE 878

  Fly   957 ---------------------KKHTGIIQEYKQIIQ----RQEQDMNTLSETLGKVMHMVSNCQD 996
                                 ||.|.||.|||||..    |.|:......|.|..|...:..|:.
Human   879 EETAQLKEVFRKQLEKAEYEIKKTTAIIAEYKQICSQLSTRLEKQQAASKEELEVVKGKMMACKH 943

  Fly   997 CQQQIDAGNDNAKSDDGKNRGQTD-AMRNANEHPLGPLDPLNAASQRIRELELELAQAKLAQVEA 1060
            |            ||.....|... |.....:..:...|..::..:::||:||||||.||..|||
Human   944 C------------SDIFSKEGALKLAATGREDQGIETDDEKDSLKKQLREMELELAQTKLQLVEA 996

  Fly  1061 ECKNQDLNHQLSNTLSELQTNRNSWQPWLSKTFNSLQEKVTTR 1103
            :||.|:|.||....::|:|..:||   |.|||.||::....|:
Human   997 KCKIQELEHQRGALMNEIQAAKNS---WFSKTLNSIKTATGTQ 1036

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GAPcenANP_001097549.1 PTB_Rab6GAP 204..332 CDD:269922 48/128 (38%)
DUF3694 429..523 CDD:289256 34/96 (35%)
TBC 650..858 CDD:214540 125/207 (60%)
Phage_Gp23 <914..991 CDD:287621 31/140 (22%)
RABGAP1LNP_001353375.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..52 3/13 (23%)
PTB_Rab6GAP 129..257 CDD:269922 49/135 (36%)
DUF3694 290..421 CDD:315198 59/150 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 461..503 14/65 (22%)
RabGAP-TBC 541..744 CDD:306939 122/202 (60%)
DUF3084 800..>1018 CDD:331293 59/231 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 268 1.000 Domainoid score I1873
eggNOG 1 0.900 - - E1_COG5210
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 626 1.000 Inparanoid score I866
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG49205
OrthoDB 1 1.010 - - D191811at2759
OrthoFinder 1 1.000 - - FOG0000497
OrthoInspector 1 1.000 - - otm41068
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR22957
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3994
SonicParanoid 1 1.000 - - X1488
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.970

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