Protein Alignment GAPcenA and RABGAP1L

DIOPT Version :10

• Sequence 1: NP_001097549.1
• Gene: GAPcenA / 38945
• FlyBaseID: FBgn0035879
• Length: 1194
• Species: Drosophila melanogaster
• Sequence 2: NP_001353375.1
• Gene: RABGAP1L / 9910
• HGNCID: 24663
• Length: 1051
• Species: Homo sapiens
• Alignment Length: 1083
• Identity: 399/1083 - (36%)
• Similarity: 565/1083 - (52%)
• Gaps: 180/1083 - (16%)

  Fly   116 HQQKSLTLPLTGSGGGSVDPEMRFPCTLFTPKSEETLDDASSSNRVGHSVFYDCIDASPACVEEK 180
            |::|. .|.:..:|...::..|.........:....|.|..||:.:....|.| |.||.......
Human    39 HEEKP-QLKIVSNGDEQLEKAMEEILRDSEKRPSSLLVDCQSSSEISDHSFGD-IPASQTNKPSL 101

  Fly   181 QDAMKPEKGDTTDEEVSE----IDQGCTIFSGVTYLGAANINAPKSETEVYRIMGELNSGSKSVG 241
            |..:.|...:.:....|.    .::...:|:.:||||...:::|::|.|..|.|..:.|.|: ..
Human   102 QLILDPSNTEISTPRPSSPGGLPEEDSVLFNKLTYLGCMKVSSPRNEVEALRAMATMKSSSQ-YP 165

  Fly   242 LKITVSIPNCSEGLVVLHDAESNTIIATYEISSIILYYRGPVDTVENGCFAFT-WLHGDALFQCH 305
            ..:|:.:||..||.|.:.|..||..||::.|..::...||...|.|:.||||| ..||...||.|
Human   166 FPVTLYVPNVPEGSVRIIDQSSNVEIASFPIYKVLFCARGHDGTTESNCFAFTESSHGSEEFQIH 230

  Fly   306 VFRCHIPEAVNQVSACFQKAFQTYPPSMSCSLNSAVDMANSV----TSDVSGNPLNTAGYEFIVS 366
            ||.|.|.|||:::...|..||:.       |.....|:.:||    .|||         :.|.||
Human   231 VFSCEIKEAVSRILYSFCTAFKR-------SSRQVSDVKDSVIPTPDSDV---------FTFSVS 279

  Fly   367 LEIRERVAKNSYAAVPRDRG--CFKLRANTDKEVCITVKQTPSNVLQPLHIERCFGVLVAPGKLV 429
            ||::|...|.:::.||:||.  .|||:...:|:|.|||:|. ||  :.|.||||||:|::||:.|
Human   280 LEVKEDDGKGNFSPVPKDRDKFYFKLKQGIEKKVVITVQQL-SN--KELAIERCFGMLLSPGRNV 341

  Fly   430 VQKDMHLIDMHSMGYIQPGGTGVATESDSNAQQSSSWPYTIRAEWKAQEKAFEQLNLESSKTN-- 492
            ...||||:||.|||....|..                 |.|...|......|..||.|:.|..
Human   342 KNSDMHLLDMESMGKSYDGRA-----------------YVITGMWNPNAPVFLALNEETPKDKQV 389

  Fly   493 -LTVAVDIVMRRIQEPVRFVIETPVTIQSASEMRIMDHFMSKRPMTLRFYLHLKRTE-------- 548
             :|||||:|:..:.|||||::||.|.:..|:| |..  :.|::..|..|::.||::|
Human   390 YMTVAVDMVVTEVVEPVRFLLETVVRVYPANE-RFW--YFSRKTFTETFFMRLKQSEGKGHTNAG 451

  Fly   549 ESNWKVNSI----DPSEEITEQPGHQQSSSLLKMGMNNLSRIVRSSSIASIEDDCPSDYSSDGDE 609
            ::.::|.|:    |..|.:|...|                     ....|.:||   :...:.|.
Human   452 DAIYEVVSLQRESDKEEPVTPTSG---------------------GGPMSPQDD---EAEEESDN 492

  Fly   610 PLLSGTGEVSKDCSQDTLDEWDPILREWDSE--KRPKNLAPLVRLGVPEALREKIWQKLANVEGR 672
            .|.||||:|||||.:..|..|..:|.:|.|.  .|||.|:.||:.|||||||.::||.||.....
Human   493 ELSSGTGDVSKDCPEKILYSWGELLGKWHSNLGARPKGLSTLVKSGVPEALRAEVWQLLAGCHDN 557

  Fly   673 MEMNDKYKILITKETKCETVIQRDIHRTFPAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQG 737
            ..|.|:|:|||||::..|:||.||||||||||..||:.||.||::|:|:.|||:|:|.::|||||
Human   558 QAMLDRYRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQG 622

  Fly   738 LSFIAASLLLHMPEEDAFCVLVALMYDYGLRDLYKAGFEVLYLRLYQLERLIKDQLPKLHEHFTA 802
            .||:||.||||||||.||||||.:||||||||||:..||.|:.:.||||||:::|||.||.||:.
Human   623 QSFLAAVLLLHMPEEQAFCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSD 687

  Fly   803 CGIETHMYASQWFLTLYTARFPLCFVFHVLDVFLLDGLPVLFQVAVTLLSICESDLRQLDFEGIL 867
            ..:|.|||||||||||:||:||||.|||::|:.|.:||.::|.||:.||...:.||.|.||||.|
Human   688 LNLEAHMYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQADFEGAL 752

  Fly   868 KYFRVTLPKKCRSSSQARKVMKQACERKI--KKLKQYEEEFLLKKQHKERLEKEAQIYENRFGEE 930
            |:|||.|||:.|:...||::|:|||..|:  ||||:||:|:  :...:.:|::|..:  :|:..|
Human   753 KFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKYEKEY--QTMRESQLQQEDPM--DRYKRE 813

  Fly   931 RRKMQA--------------------------------EIDALNKQLTSAKERAVEKE------- 956
            .|::|.                                :.|.|||:|...|:|.||.|
Human   814 NRRLQEASMRLEQENDDLAHELVTSKIALRNDLDQAEDKADVLNKELLLTKQRLVETEEEKRKQE 878

  Fly   957 ---------------------KKHTGIIQEYKQIIQ----RQEQDMNTLSETLGKVMHMVSNCQD 996
                                 ||.|.||.|||||..    |.|:......|.|..|...:..|:.
Human   879 EETAQLKEVFRKQLEKAEYEIKKTTAIIAEYKQICSQLSTRLEKQQAASKEELEVVKGKMMACKH 943

  Fly   997 CQQQIDAGNDNAKSDDGKNRGQTD-AMRNANEHPLGPLDPLNAASQRIRELELELAQAKLAQVEA 1060
            |            ||.....|... |.....:..:...|..::..:::||:||||||.||..|||
Human   944 C------------SDIFSKEGALKLAATGREDQGIETDDEKDSLKKQLREMELELAQTKLQLVEA 996

  Fly  1061 ECKNQDLNHQLSNTLSELQTNRNSWQPWLSKTFNSLQEKVTTR 1103
            :||.|:|.||....::|:|..:||   |.|||.||::....|:
Human   997 KCKIQELEHQRGALMNEIQAAKNS---WFSKTLNSIKTATGTQ 1036

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	48/128 (38%)
		DUF3694	377..523	CDD:463599	59/150 (39%)
		TBC	650..858	CDD:214540	125/207 (60%)
		SMC_prok_B	<876..>1087	CDD:274008	77/277 (28%)
		TPH	<883..>977	CDD:464007	42/159 (26%)
RABGAP1L	NP_001353375.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52		3/13 (23%)
		PTB_Rab6GAP	129..257	CDD:269922	49/135 (36%)
		DUF3694	290..421	CDD:463599	59/150 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	461..503		14/65 (22%)
		TBC	535..744	CDD:214540	126/208 (61%)
		Smc	<794..>1020	CDD:440809	59/239 (25%)