DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and SGSM2

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	XP_011522403.1	Gene:	SGSM2 / 9905	HGNCID:	29026	Length:	1103	Species:	Homo sapiens

Alignment Length:	987	Identity:	185/987 - (18%)
Similarity:	317/987 - (32%)	Gaps:	341/987 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LSTKSSESSIT-----------TSGEYE----IVTDSNVASPMEQVKQV-------------VNQ 41
            ||...|..|:|           |.|:.|    :..|..:..|..||..:             |:|
Human   326 LSLHQSAESLTLKWTPNQLMNGTLGDSELEKSVYWDYALVVPFSQVVCIHCHQQKSGGTLVLVSQ 390

  Fly    42 EGTQPEVGGKPPTSLSALALSSPEAGGDRSPTLDMAHNRNLSDMQHEMTDALKDLE-LERGVAAS 105
            :|.|     :||       |..|:.|                       ..|..|. ||.|:...
Human   391 DGIQ-----RPP-------LHFPQGG-----------------------HLLSFLSCLENGLLPR 420

  Fly   106 GEKSAQRLPSHQQKSLTLPL-TGSGGGSVDPEMRFPCTLFTPKSEETLDDASSSNRV------GH 163
            |:             |..|| |..|.|.|.|::|...::.:...|| :....:::.|      ||
Human   421 GQ-------------LEPPLWTQQGKGKVFPKLRKRSSIRSVDMEE-MGTGRATDYVFRIIYPGH 471

  Fly   164 -----SVFYDCIDASPACVEEKQDAMKPEKGDTTDEEVSEIDQGCTIFSGVTYLGAANINAPKSE 223
                 ::.|..:.||.|.              :.|::..|.|:   :.:.::.:.:.|:.||...
Human   472 RHEHITINYHHLAASRAA--------------SVDDDEEEEDK---LHAMLSMICSRNLTAPNPM 519

  Fly   224 TEVYRIMGELNSGSKSVGLKITVSIPNCSEGLVVLHDAESNTIIATYEISSII---LYYRGPVDT 285
            .:...::.....|.......:.   |.||:|...|..:.|::..||....|.|   |..|...::
Human   520 KDAGDMIEMQGFGPSLPAWHLE---PLCSQGSSCLSCSSSSSPHATPSHCSCIPDRLPLRLLCES 581

  Fly   286 VENGCFA---FTWLHGDALFQCHVFRCHIPEAVNQVSACFQKAF--QTYPPSMSCSLNSAVDMAN 345
            ::....:   :.|     |..|.    |:......:||....:.  ...||..|..|
Human   582 MKRQIVSRAFYGW-----LAHCR----HLSTVRTHLSALVHHSVIPPDRPPGASAGL-------- 629

  Fly   346 SVTSDV-SGNPLNTAGYEFIVSLEIRERVAKNSYAAVPRDRGCFKLRANTDKEVCITVKQTPSNV 409
              |.|| |....:...|:   .||:..:|   .|..:..:
Human   630 --TKDVWSKYQKDKKNYK---ELELLRQV---YYGGIEHE------------------------- 661

  Fly   410 LQPLHIERCFGVLVAPGKLVVQKDM--HLIDMHSMGYIQPGGTGVATESDSNAQQSSSWPYTIRA 472
                                ::||:  .|:..:..|..:.....|.....:..||       :.|
Human   662 --------------------IRKDVWPFLLGHYKFGMSKKEMEQVDAVVAARYQQ-------VLA 699

  Fly   473 EWKAQEKAFEQLNLES-----SKTNLTVAVDIVMRRIQEPVRFVIETPVTIQSASEMRIMDHFMS 532
            ||||.|....|...|:     :|.:...::|..::|:       |....||.:       |.|:|
Human   700 EWKACEVVVRQREREAHPATRTKFSSGSSIDSHVQRL-------IHRDSTISN-------DVFIS 750

  Fly   533 KRPMTLRFYLHLKRTEESNWKVNSIDPSEEITEQPGHQQSSSLLKMGMNNLSRIVRSSSIASIED 597
                                 |:.::|.|  .:.|...:.....:.|.......|.... .|:|.
Human   751 ---------------------VDDLEPPE--PQDPEDSRPKPEQEAGPGTPGTAVVEQQ-HSVEF 791

  Fly   598 DCP-SDYSSDGDEPLLSGTGEVSKDCSQDTLDEWDPI----------------------LREWDS 639
            |.| |...|..:..:.||.        |.:|||...:                      |||...
Human   792 DSPDSGLPSSRNYSVASGI--------QSSLDEGQSVGFEEEDGGGEEGSSGPGPAAHTLREPQD 848

  Fly   640 EKRPKNLAPLVRLGVPEALREKIWQKLANV---EGRMEMNDKYKILITKETKCETVIQRDIHRTF 701
            ..:.|          |:|...:..::||.|   ...:|:.|...:.:.:       |.:|:.|..
Human   849 PSQEK----------PQAGELEAGEELAAVCAAAYTIELLDTVALNLHR-------IDKDVQRCD 896

  Fly   702 PAHKCFKEIGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLLLHMPEED-AFCVLVALMY-- 763
            ..:..|..   ...:.|..|..:|.....:|||.||:..:.|.||:.:..:. |:.....||.
Human   897 RNYWYFTP---PNLERLRDVMCSYVWEHLDVGYVQGMCDLLAPLLVTLDNDQLAYSCFSHLMKRM 958

  Fly   764 -----DYGLRDLYKAG----FEVLYLRLYQLERLIKDQLPKLHEHFTACGIETHMY-ASQWFLTL 818
                 :.|..|.:.|.    .::|...|::|          :|::    |..||.| ..:|||..
Human   959 SQNFPNGGAMDTHFANMRSLIQILDSELFEL----------MHQN----GDYTHFYFCYRWFLLD 1009

  Fly   819 YTARFPLCFVFHVLDVF-----LLDGLPVLFQVAVTLLSICESDLR--QLDFEGILKYFR----- 871
            :........||.|.:|.     :.....||| :|:.|:......:|  .:||..|:|:|.
Human  1010 FKRELLYEDVFAVWEVIWAARHISSEHFVLF-IALALVEAYREIIRDNNMDFTDIIKFFNALHVS 1073

  Fly   872 ------VTLPKK 877
                  :|:|::
Human  1074 PQNVLSITMPRR 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922	23/135 (17%)
		DUF3694	429..523	CDD:289256	21/100 (21%)
		TBC	650..858	CDD:214540	48/228 (21%)
		Phage_Gp23	<914..991	CDD:287621
SGSM2	XP_011522403.1	RUN	90..235	CDD:280855
		PH_RUTBC	302..470	CDD:275431	39/192 (20%)
		TBC	<885..1053	CDD:214540	41/192 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900