DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GAPcenA and TBC1D5

DIOPT Version :9

Sequence 1:	NP_001097549.1	Gene:	GAPcenA / 38945	FlyBaseID:	FBgn0035879	Length:	1194	Species:	Drosophila melanogaster
Sequence 2:	NP_001127853.1	Gene:	TBC1D5 / 9779	HGNCID:	19166	Length:	817	Species:	Homo sapiens

Alignment Length:	752	Identity:	141/752 - (18%)
Similarity:	224/752 - (29%)	Gaps:	291/752 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   634 LREWDSE------KRPKNLAPLVRLGVPEALRE---KIWQKLANVEGRMEMNDKYKILITKETKC 689
            ||.|.|.      ..|:.:.....|.:...|.:   .:|.|.        ..||         :.
Human   112 LRAWYSNIKEIHITNPRKVVGQQDLMINNPLSQDEGSLWNKF--------FQDK---------EL 159

  Fly   690 ETVIQRDIHRTFPAHKCFKE--IGGSGQDALFKVSKAYAVHDSEVGYCQGLSFIAASLL------ 746
            .::|::|:.||||..:.|::  :.....|.||    .||..:.::.|.||:..:.|.::
Human   160 RSMIEQDVKRTFPEMQFFQQENVRKILTDVLF----CYARENEQLLYKQGMHELLAPIVFVLHCD 220

  Fly   747 ----LHMP------------------EEDAFCVLVALM------YDYGLRDLYKAGFEVLY---- 779
                ||..                  |.||:.|...||      :.....|..| |.|.|.
Human   221 HQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQK-GKETLMTPIP 284

  Fly   780 ----------LRLYQLERLIKDQLPKLHE-----HFTACGIETHMYASQWFLTLYTARFPLCFVF 829
                      :.:......|:|.|.|.|:     |.....|...:|..:|...|:...|||..:.
Human   285 FARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLL 349

  Fly   830 HVLDVFLLDGL----------PVLFQVAVTLLS----ICESDLRQLDFEG-----ILKYFRVTLP 875
            .|.|....|||          .:|..:...|:|    .|...|....|.|     |||...:..|
Human   350 VVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDP 414

  Fly   876 KKCRSSSQARKVMKQACERKIKKLKQYEEEFLLKKQHKERLEKEAQIYENRFGEERRKMQAEIDA 940
            |:     ..|.|..|                         .......|:.|          ..|.
Human   415 KR-----NPRPVTYQ-------------------------FHPNLDYYKAR----------GADL 439

  Fly   941 LNKQLTSAKERAVEKEKKHTGIIQEYKQII----------------------------------- 970
            :||..|:||...:...|....:|...:::|
Human   440 MNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGGPVPGGNSSSSSSVVIPTRTSAEAP 504

  Fly   971 -----QRQEQDMNTLSETL--------------GKVMHMVSNCQDCQ-------------QQIDA 1003
                 |:|:|.....||::              .:|...|....|.|             :.:..
Human   505 SHHLQQQQQQQRLMKSESMPVQLNKGDVVTGSDAQVSVPVQTLTDLQGLSSKNISSSPSVESLPG 569

  Fly  1004 G-------------NDNAKSDDGKNRGQTDAM-RNANEHPLGPLDPLNAASQRIRELELELAQAK 1054
            |             .|:..|:..::|..:..| |..:|..|              |.::...|.:
Human   570 GREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEEL--------------EAQISFLQGQ 620

  Fly  1055 LAQVEAECK--------------------NQDLNHQLSNTLSELQTNRNSWQPWLSKTFNSLQ-- 1097
            |..::|.||                    |.:...|:..:|:.|:..::..:.  |..||..|
Human   621 LNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKG--SLRFNQSQLE 683

  Fly  1098 ----EKVTTRGGHR-DNGSGGPMPSFQSYMGQAPTTLSEASSPS------GNQEYKTFAFASV-- 1149
                |::|....|. .:|.|......||.  |....:.:|||.:      ||.:  .|...|.
Human   684 AEENEQITIADNHYCSSGQGQGRGQGQSV--QMSGAIKQASSETPGCTDRGNSD--DFILISKDD 744

  Fly  1150 -GGSPKLPSKFQATKLRNSIDSLRNIVVPLDTGKTLA 1185
             |.|.:.....||..||    :||:     .:||:.|
Human   745 DGSSARGSFSGQAQPLR----TLRS-----TSGKSQA 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GAPcenA	NP_001097549.1	PTB_Rab6GAP	204..332	CDD:269922
		DUF3694	429..523	CDD:289256
		TBC	650..858	CDD:214540	57/279 (20%)
		Phage_Gp23	<914..991	CDD:287621	17/130 (13%)
TBC1D5	NP_001127853.1	TBC	79..381	CDD:214540	59/290 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900